过敏性疾病与糖尿病的相关性及潜在关联机制

doi:10.6040/j.issn.1673-3770.0.2022.411

Abstract

Abstract: Allergic diseases and diabetes mellitus(DM)are systemic chronic diseases associated with inflammation. Both conditions involve multiple organs and complex pathogenesis. However, current evidence on the relationship between allergic diseases and DM is contradictory, and there have been few reports on associated mechanisms. Most studies have reported that DM was positively associated with asthma in allergic diseases, but negatively associated with allergic rhinitis and atopic dermatitis. The different associations may be due to ethnicity and race differences. The mechanisms associated with allergic diseases and DM are not yet fully understood and may be related to pro-inflammatory pathways and blood glucose metabolism. This article reviews epidemiological and mechanistic studies related to allergic diseases and DM to enhance clinical knowledge of their co-morbidities.

Key words: Asthma, Allergic rhinitis, Atopic dermatitis, Diabetes mellitus

CLC Number:

R765

LU Gan, DENG Yuqin, TAO Zezhang. Relationship between allergic diseases and diabetes mellitus and underlying mechanisms[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 215-222.

References

[1] Bente M. The Global Asthma Report 2022[EB/OL].(2023-03-13)[2023-03-01]. http://globalasthmareport.org/
[2] Meltzer EO. Allergic rhinitis: burden of illness, quality of life, comorbidities, and control[J]. Immunol Allergy Clin North Am, 2016, 36(2): 235-248. doi:10.1016/j.iac.2015.12.002
[3] Colás C, Brosa M, Antón E, et al. Estimate of the total costs of allergic rhinitis in specialized care based on real-world data: the FERIN Study[J]. Allergy, 2017, 72(6): 959-966. doi:10.1111/all.13099
[4] Avena-Woods C. Overview of atopic dermatitis[J]. Am J Manag Care, 2017, 23(8 Suppl): S115-S123
[5] Khan DA. Allergic rhinitis and asthma: epidemiology and common pathophysiology[J]. Allergy Asthma Proc, 2014, 35(5): 357-361. doi:10.2500/aap.2014.35.3794
[6] Langan SM, Irvine AD, Weidinger S. Atopic dermatitis[J]. Lancet, 2020, 396(10247): 345-360. doi:10.1016/S0140-6736(20)31286-1
[7] Fujita T, Hemmi S, Kajiwara M, et al. Complement-mediated chronic inflammation is associated with diabetic microvascular complication[J]. Diabetes Metab Res Rev, 2013, 29(3): 220-226. doi:10.1002/dmrr.2380
[8] American Diabetes Association Professional Practice Committee. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022[J]. Diabetes Care. 2022, 45(Suppl 1): S17-S38. doi: 10.2337/dc22-S002
[9] Association AD. Diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2014, 37(Suppl 1): S81-S90. doi:10.2337/dc14-S081
[10] Dabelea D, Rewers A, Stafford JM, et al. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study[J]. Pediatrics, 2014, 133(4): e938-e945. doi:10.1542/peds.2013-2795
[11] Zhong VW, Juhaeri J, Mayer-Davis EJ. Trends in hospital admission for diabetic ketoacidosis in adults with type 1 and type 2 diabetes in England, 1998-2013: a retrospective cohort study[J]. Diabetes Care, 2018, 41(9): 1870-1877. doi:10.2337/dc17-1583
[12] Price D, Wilson AM, Chisholm A, et al. Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice[J]. J Asthma Allergy, 2016, 9: 1-12. doi:10.2147/JAA.S97973
[13] Silverberg JI, Gelfand JM, Margolis DJ, et al. Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults[J]. Ann Allergy Asthma Immunol, 2018, 121(5): 604-612.e3. doi:10.1016/j.anai.2018.07.042
[14] Mulrennan S, Baltic S, Aggarwal S, et al. The role of receptor for advanced glycation end products in airway inflammation in CF and CF related diabetes[J]. Sci Rep, 2015, 5: 8931. doi:10.1038/srep08931
[15] Yu HM, Yang J, Xiao Q, et al. Regulation of high glucose-mediated mucin expression by matrix metalloproteinase-9 in human airway epithelial cells[J]. Exp Cell Res, 2015, 333(1): 127-135. doi:10.1016/j.yexcr.2015.02.007
[16] Tiwari V, Parmar HS. Diabetogenic effects of Parthinium hysterophorous induced allergic rhinitis[J]. Inflamm Allergy Drug Targets, 2012, 11(6): 492-498. doi:10.2174/187152812803590019
[17] Smew AI, Lundholm C, Sävendahl L, et al. Familial coaggregation of asthma and type 1 diabetes in children[J]. JAMA Netw Open, 2020, 3(3): e200834. doi:10.1001/jamanetworkopen.2020.0834
[18] Metsälä J, Lundqvist A, Virta LJ, et al. The association between asthma and type 1 diabetes: a paediatric case-cohort study in Finland, years 1981-2009[J]. Int J Epidemiol, 2018, 47(2): 409-416. doi:10.1093/ije/dyx245
[19] George C, Ducatman AM, Conway BN. Increased risk of respiratory diseases in adults with Type 1 and Type 2 diabetes[J]. Diabetes Res Clin Pract, 2018, 142: 46-55. doi:10.1016/j.diabres.2018.05.029
[20] Shapiro M, Arbel C, Zucker I, et al. Asthma in youth and early-onset type 2 diabetes: a nationwide study of 1.72 million Israeli adolescents[J]. J Clin Endocrinol Metab, 2021, 106(12): e5043-e5053. doi:10.1210/clinem/dgab542
[21] Baek JY, Lee SE, Han K, et al. Association between diabetes and asthma: evidence from a nationwide Korean study[J]. Ann Allergy Asthma Immunol, 2018, 121(6): 699-703. doi:10.1016/j.anai.2018.08.008
[22] Mueller NT, Koh WP, Odegaard AO, et al. Asthma and the risk of type 2 diabetes in the Singapore Chinese Health Study[J]. Diabetes Res Clin Pract, 2013, 99(2): 192-199. doi:10.1016/j.diabres.2012.11.019
[23] Rayner LH, McGovern A, Sherlock J, et al. The impact of therapy on the risk of asthma in type 2 diabetes[J]. Clin Respir J, 2019, 13(5): 299-305. doi:10.1111/crj.13011
[24] Villa-Nova H, Spinola-Castro AM, Garcia FE, et al. Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus[J]. Allergol Immunopathol(Madr), 2015, 43(2): 157-161. doi:10.1016/j.aller.2013.11.009
[25] Kowalczyk A, Szalecki M. Allergic diseases in children with type 1 diabetes[J]. Pediatr Endocrinol Diabetes Metab, 2013, 19(3): 100-105
[26] Lee TK, Jeon YJ, Jung SJ. Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea[J]. Sci Rep, 2021, 11(1): 4344. doi:10.1038/s41598-021-83787-9
[27] Schmitt J, Schwarz K, Baurecht H, et al. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes[J]. J Allergy Clin Immunol, 2016, 137(1): 130-136. doi:10.1016/j.jaci.2015.06.029
[28] Drucker AM, Qureshi AA, Dummer TJB, et al. Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project[J]. Br J Dermatol, 2017, 177(4): 1043-1051. doi:10.1111/bjd.15727
[29] Andersen YMF, Egeberg A, Gislason GH, et al. Adult atopic dermatitis and the risk of type 2 diabetes[J]. J Allergy Clin Immunol, 2017, 139(3): 1057-1059. doi:10.1016/j.jaci.2016.08.049
[30] Silverberg JI, Greenland P. Eczema and cardiovascular risk factors in 2 US adult population studies[J]. J Allergy Clin Immunol, 2015, 135(3): 721-728.e6. doi:10.1016/j.jaci.2014.11.023
[31] Khateeb J, Fuchs E, Khamaisi M. Diabetes and lung disease: a neglected relationship[J]. Rev Diabet Stud, 2019, 15: 1-15. doi:10.1900/RDS.2019.15.1
[32] Padem N, Saltoun C. Classification of asthma[J]. Allergy Asthma Proc, 2019, 40(6): 385-388. doi:10.2500/aap.2019.40.4253
[33] Jones TL, Neville DM, Chauhan AJ. Diagnosis and treatment of severe asthma: a phenotype-based approach[J]. Clin Med(Lond), 2018, 18(Suppl 2): s36-s40. doi:10.7861/clinmedicine.18-2-s36
[34] D'Amato G, Ortega OPM, Annesi-Maesano I, et al. Prevention of allergic asthma with allergen avoidance measures and the role of exposome[J]. Curr Allergy Asthma Rep, 2020, 20(3): 8. doi:10.1007/s11882-020-0901-3
[35] Frisbee SJ, Brooks AP Jr, Maher A, et al. The C8 health project: design, methods, and participants[J]. Environ Health Perspect, 2009, 117(12): 1873-1882. doi:10.1289/ehp.0800379
[36] Koskela HO, Salonen PH, Romppanen J, et al. A history of diabetes but not hyperglycaemia during exacerbation of obstructive lung disease has impact on long-term mortality: a prospective, observational cohort study[J]. BMJ Open, 2015, 5(1): e006794. doi:10.1136/bmjopen-2014-006794
[37] Zhang P, Lopez R, Attaway AH, et al. Diabetes mellitus is associated with worse outcome in patients hospitalized for asthma[J]. J Allergy Clin Immunol Pract, 2021, 9(4): 1562-1569.e1. doi:10.1016/j.jaip.2020.10.054
[38] Akirav EM, Henegariu O, Preston-Hurlburt P, et al. The receptor for advanced glycation end products(RAGE)affects T cell differentiation in OVA induced asthma[J]. PLoS One, 2014, 9(4): e95678. doi:10.1371/journal.pone.0095678
[39] Peters MC, McGrath KW, Hawkins GA, et al. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts[J]. Lancet Respir Med, 2016, 4(7): 574-584. doi:10.1016/S2213-2600(16)30048-0
[40] Sindhu S, Koshy M, Al-Roub AA, et al. Differential association of plasma monocyte chemoattractant protein-1 with systemic inflammatory and airway remodeling biomarkers in type-2 diabetic patients with and without asthma[J]. J Diabetes Metab Disord, 2015, 15: 40. doi:10.1186/s40200-016-0264-4
[41] Bergantin LB. The interplay between asthma and other diseases: role of Ca2+/cAMP signalling[J]. Endocr Metab Immune Disord Drug Targets, 2020, 20(3): 321-327. doi:10.2174/1871530319666190828145854
[42] Zolnikova OY, Potskhverashvili ND, Kudryavtseva AV, et al. Changes in gut microbiota with bronchial asthma[J]. Ter Arkh, 2020, 92(3): 56-60. doi:10.26442/00403660.2020.03.000554
[43] Ozerskaia IV, Geppe NA, Romantseva EV, et al. Prospects for the correction of intestinal microbiota in the prevention and treatment of asthma in children[J]. Vopr Pitan, 2021, 90(4): 74-83. doi:10.33029/0042-8833-2021-90-4-74-83
[44] Gülden E, Chao C, Tai NW, et al. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells[J]. J Autoimmun, 2018, 93: 57-65. doi:10.1016/j.jaut.2018.06.003
[45] Velloso LA, Folli F, Saad MJ. TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation[J]. Endocr Rev, 2015, 36(3): 245-271. doi:10.1210/er.2014-1100
[46] Firouzi S, Majid HA, Ismail A, et al. Effect of multi-strain probiotics(multi-strain microbial cell preparation)on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial[J]. Eur J Nutr, 2017, 56(4): 1535-1550. doi:10.1007/s00394-016-1199-8
[47] 倪璟滋, 万文锦, 程雷. 变应性鼻炎健康相关生活质量研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 110-115, 122. doi: 10.6040/j.issn.1673-3770.1.2021.165 NI Jingzi, WAN Wenjin, CHENG Lei. Research progress on health-related quality of life in allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 110-115, 122. doi: 10.6040/j.issn.1673-3770.1.2021.165
[48] 林一杭, 李幼瑾. 肠道微生态在儿童变应性鼻炎中的研究现状[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 116-122. doi: 10.6040/j.issn.1673-3770.0.2021.496 LIN Yihang, LI Youjin. Research progress on gut microbiome in children with allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 116-122. doi: 10.6040/j.issn.1673-3770.0.2021.496
[49] Bousquet J, Anto JM, Bachert C, et al. Allergic rhinitis[J]. Nat Rev Dis Primers, 2020, 6(1): 95. doi:10.1038/s41572-020-00227-0
[50] D'Amato G, Holgate ST, Pawankar R, et al. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization[J]. World Allergy Organ J, 2015, 8(1): 25. doi:10.1186/s40413-015-0073-0
[51] Schoemaker AA, Sprikkelman AB, Grimshaw KE, et al. Incidence and natural history of challenge-proven cow's milk allergy in European children: EuroPrevall birth cohort[J]. Allergy, 2015, 70(8): 963-972. doi:10.1111/all.12630
[52] Xepapadaki P, Fiocchi A, Grabenhenrich L, et al. Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study[J]. Allergy, 2016, 71(3): 350-357. doi:10.1111/all.12801
[53] Osborne NJ, Koplin JJ, Martin PE, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants[J]. J Allergy Clin Immunol, 2011, 127(3): 668-676.e1-2. doi:10.1016/j.jaci.2011.01.039
[54] Peters RL, Koplin JJ, Gurrin LC, et al. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up[J]. J Allergy Clin Immunol, 2017, 140(1): 145-153.e8. doi:10.1016/j.jaci.2017.02.019
[55] Gonzalez-Estrada A, Radojicic C. Penicillin allergy: a practical guide for clinicians[J]. Cleve Clin J Med, 2015, 82(5): 295-300. doi:10.3949/ccjm.82a.14111
[56] Jandus P, Harr T. Sulfonamide allergy and cross-reactivity[J]. Rev Med Suisse, 2013, 9(382): 798-802
[57] Schuler Iv CF, Montejo JM. Allergic rhinitis in children and adolescents[J]. Pediatr Clin North Am, 2019, 66(5): 981-993. doi:10.1016/j.pcl.2019.06.004
[58] Papadopoulos NG, Bernstein JA, Demoly P, et al. Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report[J]. Allergy, 2015, 70(5): 474-494. doi:10.1111/all.12573
[59] Krischer JP, Cuthbertson D, Couluris M, et al. Association of diabetes-related autoantibodies with the incidence of asthma, eczema and allergic rhinitis in the TRIGR randomised clinical trial[J]. Diabetologia, 2020, 63(9): 1796-1807. doi:10.1007/s00125-020-05188-3
[60] Juneja L, Parmar HS. Ovalbumin induced allergic rhinitis and development of prediabetes to rats: possible role of Th2 cytokines[J]. Inflamm Allergy Drug Targets, 2013, 12(3): 199-205. doi:10.2174/1871528111312030007
[61] Meng X, Zhang G, Cao H, et al. Gut dysbacteriosis and intestinal disease: mechanism and treatment[J]. J Appl Microbiol, 2020, 129(4): 787-805. doi:10.1111/jam.14661
[62] Ni J, Friedman H, Boyd BC, et al. Early antibiotic exposure and development of asthma and allergic rhinitis in childhood[J]. BMC Pediatr, 2019, 19(1): 225. doi:10.1186/s12887-019-1594-4
[63] Miraglia Del Giudice M, Indolfi C, Capasso M, et al. Bifidobacterium mixture(B longum BB536, B infantis M-63, B breve M-16V)treatment in children with seasonal allergic rhinitis and intermittent asthma[J]. Ital J Pediatr, 2017, 43(1): 25. doi:10.1186/s13052-017-0340-5
[64] Xi Y, Jiao WE, Li F, et al. Association between 19 allergens and chronic constipation in adults: NHANES 2005-2006[J]. Int Arch Allergy Immunol, 2022: 1-9. doi:10.1159/000527159
[65] Dizon MP, Yu AM, Singh RK, et al. Systematic review of atopic dermatitis disease definition in studies using routinely collected health data[J]. Br J Dermatol, 2018, 178(6): 1280-1287. doi:10.1111/bjd.16340
[66] Paternoster L, Standl M, Waage J, et al. Multi-ancestry genome-wide association study of 21,000 cases and 95, 000 controls identifies new risk loci for atopic dermatitis[J]. Nat Genet, 2015, 47(12): 1449-1456. doi:10.1038/ng.3424
[67] Tsakok T, Woolf R, Smith CH, et al. Atopic dermatitis: the skin barrier and beyond[J]. Br J Dermatol, 2019, 180(3): 464-474. doi:10.1111/bjd.16934
[68] Halling-Overgaard AS, Kezic S, Jakasa I, et al. Skin absorption through atopic dermatitis skin: a systematic review[J]. Br J Dermatol, 2017, 177(1): 84-106. doi:10.1111/bjd.15065
[69] Baurecht H, Rühlemann MC, Rodríguez E, et al. Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration[J]. J Allergy Clin Immunol, 2018, 141(5): 1668-1676.e16. doi:10.1016/j.jaci.2018.01.019
[70] Kurita M, Yoshihara Y, Ishiuji Y, et al. Expression of T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain on CD4+ T cells in patients with atopic dermatitis[J]. J Dermatol, 2019, 46(1): 37-42. doi:10.1111/1346-8138.14696
[71] Spence A, Purtha W, Tam J, et al. Revealing the specificity of regulatory T cells in murine autoimmune diabetes[J]. Proc Natl Acad Sci U S A, 2018, 115(20): 5265-5270. doi:10.1073/pnas.1715590115
[72] Marro BS, Ware BC, Zak J, et al. Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling[J]. Proc Natl Acad Sci U S A, 2017, 114(14): 3708-3713. doi:10.1073/pnas.1700878114
[73] Fuhrman CA, Yeh WI, Seay HR, et al. Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226[J]. J Immunol, 2015, 195(1): 145-155. doi:10.4049/jimmunol.1402381
[74] Li Y, Xu W, Yao JY, et al. Correlation of blood FoxP3+ regulatory T cells and disease activity of atopic dermatitis[J]. J Immunol Res, 2019, 2019: 1820182. doi:10.1155/2019/1820182
[75] García EM, Galicia-Carreón J, Novak N. In vitro conversion into CD4+CD25+Foxp3+ induced regulatory T cells is reduced in atopic dermatitis patients[J]. Int Arch Allergy Immunol, 2020, 181(5): 353-356. doi:10.1159/000506285
[76] Moosbrugger-Martinz V, Gruber R, Ladstätter K, et al. Filaggrin null mutations are associated with altered circulating Tregs in atopic dermatitis[J]. J Cell Mol Med, 2019, 23(2): 1288-1299. doi:10.1111/jcmm.14031
[77] Grant CR, Liberal R, Mieli-Vergani G, et al. Regulatory T-cells in autoimmune diseases: challenges, controversies and: yet: unanswered questions[J]. Autoimmun Rev, 2015, 14(2): 105-116. doi:10.1016/j.autrev.2014.10.012
[78] Qiao YC, Pan YH, Ling W, et al. The Yin and Yang of regulatory T cell and therapy progress in autoimmune disease[J]. Autoimmun Rev, 2017, 16(10): 1058-1070. doi:10.1016/j.autrev.2017.08.001
[79] Hull CM, Peakman M, Tree TIM. Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?[J]. Diabetologia, 2017, 60(10): 1839-1850. doi:10.1007/s00125-017-4377-1
[80] Paul M, Dayal D, Bhansali A, et al. Characterization of proinsulin-specific regulatory T cells in type 1 diabetes at different ages of onset[J]. Pediatr Diabetes, 2019, 20(3): 271-281. doi:10.1111/pedi.12813
[81] Ihantola EL, Viisanen T, Gazali AM, et al. Effector T cell resistance to suppression and STAT3 signaling during the development of human type 1 diabetes[J]. J Immunol, 2018, 201(4): 1144-1153. doi:10.4049/jimmunol.1701199
[82] Gao YR, Sun XZ, Li R, et al. The effect of regulatory T cells in Schistosoma-mediated protection against type 2 diabetes[J]. Acta Trop, 2021, 224: 106073. doi:10.1016/j.actatropica.2021.106073
[83] Leung OM, Li JT, Li XS, et al. Regulatory T cells promote apelin-mediated sprouting angiogenesis in type 2 diabetes[J]. Cell Rep, 2018, 24(6): 1610-1626. doi:10.1016/j.celrep.2018.07.019
[84] Murzina E, Kaliuzhna L, Bardova K, et al. Human skin microbiota in various phases of atopic dermatitis[J]. Acta Dermatovenerol Croat, 2019, 27(4): 245-249.
[85] Melli LCFL, Carmo-Rodrigues MSD, Araújo-Filho HB, et al. Gut microbiota of children with atopic dermatitis: controlled study in the metropolitan region of São Paulo, Brazil[J]. Allergol Immunopathol(Madr), 2020, 48(2): 107-115. doi:10.1016/j.aller.2019.08.004
[86] Olaimat AN, Aolymat I, Al-Holy M, et al. The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19[J]. NPJ Sci Food, 2020, 4: 17. doi:10.1038/s41538-020-00078-9

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