盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察

山东大学耳鼻喉眼学报

盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察

薛卫国，孙洁，金铮，石文斌，辛露，林国经，李加耘

1. 青岛市立医院耳鼻咽喉-头颈外科，山东青岛 266011；2. 青岛市立医院药剂科, 山东青岛 266011；3. 福建医科大学附属协和医院耳鼻咽喉-头颈外科, 福建福州 350000；4. 陕西省人民医院耳鼻咽喉-头颈外科, 陕西西安 710000

收稿日期:2006-03-29 修回日期:1900-01-01 出版日期:2006-08-24 发布日期:2006-08-24
通讯作者: 薛卫国

XUE Wei-guo,SUN Jie,JIN Zheng，SHI Wen-bin,XIN Lu,LIN Guo-Jing, LI Jia-yun

1. Department of Otolaryngology ＆ Head and Neck Surgery, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China; 2. Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011,

Received:2006-03-29 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
Contact: XUE Wei-guo

摘要/Abstract

摘要： 目的：评价盐酸左氧氟沙星滴耳液治疗中耳炎的有效性和安全性。方法：采用同类有效药物氧氟沙星滴耳液作为对照，进行随机、双盲、阳性药物平行对照、多中心临床试验。结果：完成试验方案的可供疗效分析的患者120例,试验组和对照组各60例。试验组有效率为96.67%，细菌清除率为96.15%；对照组分别为85.00%和95.83%，两组差异无统计学意义(P均＞0.05)。结论：盐酸左氧氟沙星滴耳液治疗中耳炎疗效显著，细菌清除率高，安全性好，与氧氟沙星滴耳液疗效相近。

关键词: 中耳炎, 左氧氟沙星, 氧氟沙星, 治疗结果

Abstract: To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media. Method: A randomized, doubleblind, multicenter, ofloxacin ear drop controlled trial was performed. Results: The data of 120 patients were analyzed, and 60 patients were in the group of levofloxacin ear drop and the other 60 in the group of ofloxacin ear drop. Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00%; the eradication rate of pathogens in the group of levofloxacin ear drop was 96.15% and in the group of ofloxacin ear drop was 95.83%. No significant difference was showed between two groups (both P＜0.05). Conclusions: Levofloxacin ear drop is effective and safe in treating otitis media. The efficacy of levofloxacin ear drop is similar to that of ofloxacin ear drop.

Key words: Levofloxacin, Otitis media, Ofloxacin, Treatment outcome

薛卫国,孙洁,金铮,石文斌,辛露,林国经,李加耘 . 盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察[J]. 山东大学耳鼻喉眼学报, 2006, 20(4): 300-303 .

XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(4): 300-303 .

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