山东大学耳鼻喉眼学报

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阿奇霉素对慢性鼻窦炎鼻息肉患者术腔黏膜上皮化的影响

白永, 李娜, 张念凯   

  1. 青岛大学医学院附属医院耳鼻咽喉-头颈外科, 山东 青岛 266003
  • 收稿日期:2006-08-31 修回日期:1900-01-01 出版日期:2006-10-24 发布日期:2006-10-24
  • 通讯作者: 白永

BAI Yong,LI Na,ZHANG Nian-kai   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong, China
  • Received:2006-08-31 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: BAI Yong

摘要: 目的:观察阿奇霉素对慢性鼻窦炎鼻息肉患者术后术腔黏膜上皮化的影响。方法:随访59例行鼻内镜手术的慢性鼻窦炎、鼻息肉患者,患者术后均用布地奈德喷鼻,1月后头孢菌素组37例加用头孢丙烯500?mg,口服,每日1次,共3周;阿奇霉素组22例加用阿奇霉素500?mg,口服,每日1次,共3周;观察2组术腔黏膜上皮化的情况和时间。结果:随访6个月,头孢菌素组28例上皮化,9例在随访期间未上皮化;阿奇霉素组22例均上皮化,两组比较差异有统计学意义(χ2=4.573,P=0.033)。头孢菌素组22~126?d黏膜上皮化,平均(51.143±27.655?)d,阿奇霉素组11~83?d上皮化,平均(33.046±18.874)?d,两组差异有统计学意义(t=2.624,P=0.006)。结论:阿奇霉素治疗慢性鼻窦炎鼻息肉术后术腔黏膜慢性炎症、促进术腔黏膜上皮化有良好的疗效,可作为患者术后治疗的一种选择。

关键词: 鼻窦炎, 慢性, 外科手术, 鼻黏膜, 阿奇霉素

Abstract: To observe the effect of Azithromycin on the epithelialization of nasal mucosal of chronic sinusitis after endoscopic sinus surgery. Methods: From December 2004 to December 2005, 59 patients with chronic sinusitis and/or nasal polyp were treated with endoscopic surgery. One month after the operation, they were divided into two groups, and 37 patients were treated with cephamycin as a control group and 22 with Azithromycin as a experimental group. The course and the number of epithelialization were counted. Results: Within 6 months, epithelialization happened in 22126 days( average 51.1423±27.655 days) in control group, and in 1188 days( average 33.046±18.874 days) in experimental group, and the difference was statistically significant(t=2.624, P=0.006). Epithelialization happened in 28 cases in the control group and 22 cases in experimental group, and the difference was also statistically significant (χ2=4.573, P=0.033). Conclusion: Azithromycin is effective in accelerating the epithelialization of nasal mucosa after endoscopic sinus surgery.

Key words: chronic, Sinusitis, Surgical procedures, operative, Nasal mucosa

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