山东大学耳鼻喉眼学报

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鼻息肉的组织病理学特征及其发病机制

闫 舒1,李 娜1,杨艳华2,姜长青2   

  1. 1. 青岛大学医学院附属医院耳鼻咽喉-头颈外科, 山东 青岛 266003;2. 青岛市立医院病理科, 山东 青岛 266011
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-02-24 发布日期:2008-02-24
  • 通讯作者: 闫 舒

Histopathological characteristics and possible mechanisms of nasal polyps

YAN Shu1,LI Na1,YANG Yan-hua2,JIANG Chang-qing2   

  1. 1. Department of Otolaryngology & Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003;2. Department of Pathology, Qingdao Municipal Hospital, Qingdao 266011, Shandong
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-02-24 Published:2008-02-24
  • Contact: YAN Shu

摘要: 目的观察鼻息肉的组织细胞学特征,探讨鼻息肉的发病机制。方法应用常规组织学方法及甲苯胺蓝特殊染色法观察134例鼻息肉组织中嗜酸性粒细胞、淋巴细胞、浆细胞、中性粒细胞和肥大细胞的浸润情况,并进行计数、分组及统计学处理。结果:134例鼻息肉组织中嗜酸性粒细胞聚集型有69例,占51.49%,淋巴细胞聚集型有52例,占38.81%,混合型有10例,占7.46%;中性粒细胞聚集型有3例,占2.24%。4组间嗜酸性粒细胞数、淋巴细胞数、肥大细胞数、中性粒细胞数和浆细胞数差异均有统计学意义(P<0.01)。嗜酸性粒细胞数与肥大细胞数呈负相关(r=-0.534,P<0.01),淋巴细胞数与肥大细胞数呈正相关(r=0.601,P<0.01),浆细胞数与肥大细胞数呈正相关(r=0.202,P<0.05)。结论鼻息肉中嗜酸性粒细胞聚集似乎与肥大细胞及Ⅰ型变态反应无关, 各种炎性细胞的浸润及相互作用是导致鼻息肉发生发展的重要环节,鼻息肉的组织病理学分型对探讨鼻息肉的发病机制有一定帮助。

关键词: 鼻息肉, 嗜酸性粒细胞, 淋巴细胞, 肥大细胞, 浆细胞

Abstract: To explore the correlation between histopathological characteristics and mechanism of nasal polyps. MethodsNasal polyps of each patient who underwent nasal endoscopic sinus surgery were stained with HE and Toluidine Blue to count the number of eosiophils, lymphocytes, mast cells, plasma cells and neutrophil cells under a light microscope and were divided into 4 groups according to their histopathological characteristics. The data of the 4 groups were analyzed with One-Way ANOVA. ResultsEosinophils were found in 69(51.49%) nasal polyps, lymphocytes were found in 52(38.81%) nasal polyps, both of them were found in 10(7.46%) nasal polyps, and neutrophil cells were found in 3(2.24%) nasal polyps. Furthermore, the difference of the mean number of eosinophils among the 4 groups was significant (P<0.05). The difference was also significant in lymphocyte number, mast cell number, plasma cell number and neutrophil cell number. The number of eosinophils and mast cells was negatively correlated(r=-0.534,P<0.01), while the number of lymphocytes and mast cells was positively correlated(r=0.601,P<0.01), and the number of plasma cells and mast cells was positively correlated(r=0.202,P<0.05). ConclusionsThe accumulation of eosinophils in the nasal polyps does not appear to be related to the presence of mast cells and allergy. The infiltration of inflammatory cells and their interaction may be important steps in the formation of nasal polyps. The histopathological classification of nasal polyps may be helpful for exploring the mechanisms of nasal polyps.

Key words: Eosinophil, Lymphocytes, Nasal polyps, Mast cells, Plasma cells

中图分类号: 

  • R765.25
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