JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (1): 8-11.doi: 10.6040/j.issn.1673-3770.0.2014.223

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The relationship between brain derived neurotrophic factor and obstructive sleep apnea syndrome

ZHANG Chan-juan, LI Yan-zhong, WANG Yan   

  1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, Shandong, China
  • Received:2014-07-02 Online:2015-02-16 Published:2015-02-16

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Abstract: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a serious, chronic sleep breathing disorder. OSAHS may affect the cardiovascular, nervous, and endocrine systems, resulting in series of concurrent symptoms. Brain-derived neurotrophic factor (BDNF) is a protein produced by brain tissues. BDNF is the most abundant and widely distributed member of the neurotrophic factor family. Recent years, a number of studies suggested that the expression of BDNF was often abnormal in OSAHS. This paper summarizes the latest research results, and the role of BDNF in the pathogenesis mechanism will be reviewed to bring up the possible clues for further study.

Key words: Pathogenesis, Obstructive sleep apnea-hypopnea syndrome, Brain-derived neurotrophic factor

CLC Number: 

  • R766.7
[1] Peppard P E, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension[J]. N Engl J Med, 2000, 342(19): 1378-1384.
[2] Harsch l A, Schahin S P, Radespiel-Troger M, et al. CPAP treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome[J]. Am J Respir Crit Care Med, 2004, 169(2): 156-162.
[3] 王卫红.OSAHS对认知功能的影响及相关[D].长沙:中南大学,2012. WANG Weihong. Cognitive imparirment in OSAHSpatients and its related mechanism[D]. Changsha:Central South University, 2012.
[4] Zhou X P, Wu K Y, Liang B, et al. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis[J]. Proc Natl Acad Sci U S A, 2008, 105(44):17181-17186.
[5] Pereira A C, Huddleston D E, Brickman A M, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus[J]. Proc Natl Acad Sci U S A, 2007, 104(13):5638-5643.
[6] McHughen S A, Rodriguez P F, Kleim J A, et al. BDNF val66met polymorphism influences motor system function in the human brain[J]. Cereb Cortex, 2010, 20(5):1254-1262.
[7] McHughen S A, Rodriguez P F, Kleim J A, et al. BDNF val66met polymorphism influences motor system function in the human brain[J]. Cereb Cortex, 2010, 20(5):1254-1262.
[8] Kamba M, Inoue Y, Higami S, et al. Cerebral metabolic impairment in patients with sleep apnoea: an independent association of obstructive sleep apnoea with white matter change[J]. J Neurol Neurosurg Psychiatry, 2001, 71(3):334-339.
[9] Ji Y, Pang P T, Feng L, et al. Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons[J]. Nat Neurosci, 2005, 8(2):164-172.
[10] Li Y, Jia Y C, Cui K, et al. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor[J]. Nature, 2005, 434(7035):894-898.
[11] Zhou J, Du W, Zhou K, et al. Critical role of TRPC6 channels in the formation of excitatory synapses[J]. Nat Neurosci, 2008, 11(7):741-743.
[12] Gosselin N, Mathieu A, Mazza S, et al. Attentional deficits in patients with obstructive sleep apnea syndrome:an event related potential study[J]. Clin Neurophysiol, 2006, 117(10):2228-2235.
[13] Bawden F C, Oliveira C A, Caramelli P. Impact of obstructive sleep apnea on cognitive performance[J]. Arquivos De Neuro-Psiquiatia, 2011, 69(4)585-589.
[14] Knipper M, Berzaghi M P, Blochl A, et al. Positive feed back between acetyl choline and the neurotrophins nerve growth factor and brain derived neurotrophic factor in the rat hippocampus[J]. Eur J Neuroci, 1994, 6(2):668-671.
[15] Messaoudi E, Barsen K, Srebro B, et al. Acute intrahippocampal in fusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus[J]. J Neurophysiol, 1998, 79(1):496-499.
[16] Jiang Q S, Liang Z L, Wu M J, et al. Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMPS mice[J]. Chin Med J (Engl), 2011, 4(10):1540-1544.
[17] Laring K, Mitchell D, Wersching H, et al. Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?[J]. Age (Dorde), 2012,34(4):1011-1022.
[18] Worsnop C, Kay A, Pierce R, et al. Activity of respiratory pump and upper airway muscles during sleep onset[J]. J Appl Physiol, 1998, 85(3):908-920.
[19] Svanborg E. Impact of obstructive apnea syndrome on upper airway respiratory muscles[J]. Respir Physiol Neurobiol, 2005, 147(2-3):263-272.
[20] Caravagna C, Soliz J, Seaborn T. Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration[J]. Eur J Neurosci, 2013, 38(9):3261-3269.
[21] Saunamki T, Jenkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review[J]. Acta Neurol Scand, 2007, 116 (5):277-288.
[22] 韩建芳.男性阻塞性睡眠呼吸暂停综合征患者性激素研究[D].广州:南方医科大学,2013. HAN Jianfang. Sex hormone changes in male patients with obstructive sleep apnea hypopnea syndrome[D]. Guangzhou: Southern Medical University, 2013.
[23] 王春强.神经营养素-4及其受体在牛成熟精子和支持细胞中的表达与功能研究[D].长春:吉林大学,2013. WANG Chunqiang. Expyession and function of neurotrophin-4 and its receptor in bovin mature spermatozoa and Sertoli cells[D]. Changchun: Jilin University, 2013.
[24] Barde Y A, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mamalian brain[J]. EMBO J, 1982, 1(5):549-553.
[25] Friedel S, Horro F F,Wermter A K, et al. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit hyperactivity disorder[J]. Am J Med Genet B Neuropsychiatr Genet, 2005, 132B(1):96-99.
[26] Nakazato M, Hashimoto K, Shimizu E, et al. Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders[J]. Biol Psychiatry, 2003, 54(4):485-490.
[27] Hirsch S, Labes M, Bhr M. Changes in BDNF and neurotrophin receptor expression in degenerating and regenerating rat retinal ganglion cells[J]. Restor Neurol Neurosci, 2000, 17(2-3):125-134.
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