JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (1): 8-11.doi: 10.6040/j.issn.1673-3770.0.2014.223

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The relationship between brain derived neurotrophic factor and obstructive sleep apnea syndrome

ZHANG Chan-juan, LI Yan-zhong, WANG Yan   

  1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, Shandong, China
  • Received:2014-07-02 Online:2015-02-16 Published:2015-02-16

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Abstract: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a serious, chronic sleep breathing disorder. OSAHS may affect the cardiovascular, nervous, and endocrine systems, resulting in series of concurrent symptoms. Brain-derived neurotrophic factor (BDNF) is a protein produced by brain tissues. BDNF is the most abundant and widely distributed member of the neurotrophic factor family. Recent years, a number of studies suggested that the expression of BDNF was often abnormal in OSAHS. This paper summarizes the latest research results, and the role of BDNF in the pathogenesis mechanism will be reviewed to bring up the possible clues for further study.

Key words: Pathogenesis, Obstructive sleep apnea-hypopnea syndrome, Brain-derived neurotrophic factor

CLC Number: 

  • R766.7
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