JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (5): 14-18.doi: 10.6040/j.issn.1673-3770.0.2015.172

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An investigation on the test of bone mineral density in middle-aged men with obstructive sleep apnea hypopnea syndrome

LI Jufen1, MU Chao1, WANG Yan2, LI Yanzhong2   

  1. 1. Department of Otorhinolaryngology, Tongchuan People's Hospital, Tongchuan 727000, Shanxi, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University, Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, Shandong, China
  • Received:2015-04-27 Revised:2015-09-22 Online:2015-10-16 Published:2015-10-16

Abstract: Objective To investigate the changes of bone mineral density (BMD) in middle-aged men with obstructive sleep apnea hypopnea syndrome (OSAHS), in order to explore the correlation between OSASH and BMD. Methods A total of 48 OSASH cases were enrolled as the OSAHS group, and 28 healthy male served as the control group. All subjects were monitored with PSG. Blood biochemical and other indexes were tested. BMD was measured with DXA. Patients in the OSAHS group were subdivided according to values of AHI and LSaO2. The changes of different indexes in different subgroups were compared, and the correlation between OSAHS BMD was analyzed. Results ① There was no statistical difference in BMD between the OSAHS group and control group (χ2=0.262, P>0.05), and between mild-to-moderate OSAHS subgroup and severe OSAHS subgroup (χ2=2.508, P>0.05), but there was difference between mild-to-moderate hypoxia subgroup and severe hypoxia subgroup (χ2=5.073, P<0.05). ② There were statistical differences in body weight index (BMI) and triglyceride (TG) between the control group and OSASH group (both P<0.05). There was statistical difference in TG between the mild-to-moderate hypoxia and severe hypoxia subgroups (P<0.05). ③ In the OSAHS group, 13 cases were complicated with dyslipidemia, 5 cases with high blood pressure, 1 case with type II diabetes, 7 cases with abnormal glucose tolerance. Conclusion The change of bone mass density is not correlated with OSASH in middle-aged male. LSaO2 has larger effects than AHI on the change of bone mass density.

Key words: Middle-aged men, Bone mineral density, Sleep apnea hypopnea syndrome, obstructive, Low ventilation syndrome

CLC Number: 

  • R766.7
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