JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (5): 98-100.doi: 10.6040/j.issn.1673-3770.0.2015.426

Previous Articles     Next Articles

Long-term curative effect of CO2 laser surgery for glottic laryngeal carcinoma.

MA Lingguo, ZHENG Chaopan, ZHOU Jingchun, ZHANG Bo, GONG Taogen, ZHANG Yunjing   

  1. Department of Otolaryngology &Head and Neck Surgery, Shenzhen Peoples Hospital / Second Clinical College of Jinan University, Shenzhen 518020, Guangdong, China
  • Received:2015-10-15 Online:2016-10-20 Published:2016-10-20

PDF (PC)

595

Abstract: Objective To evaluate the long-term curative effect of CO2 laser surgery for glottic laryngeal carcinoma under microscopic suspension laryngoscope. Methods Clinical data of 106 cases of glottic laryngeal carcinoma were retrospectively analyzed, including 4 cases of TisN0M0, 62 cases of T1aN0M0, 16 cases of T1bN0M0, 22 cases of T2N0M0, and 2 cases of T3N0M0. All cases were treated with microscopic suspension laryngoscope CO2 laser surgery during 2004 and 2015. Results All operations were successful without serious complications. Of all 106 cases, 4 died of recurrence, 4 died of accidents, 2 died of distant metastases, 4 failed to be followed up, and 2 received a second operation due to recurrence and survived well. A total 92 patients were still alive without recurrence, with good quality of life. The 3, 5 and 10-year survival rate were respectively 98.7%, 95.2% and 89.0%. The local recurrence rate was 5.7%. Conclusion Microscopic suspension laryngoscope CO2 laser surgery is the preferred method for glottic laryngeal carcinoma Tis and T1a, which produces few surgical trauma, fast postoperative recovery, good laryngeal function preservation and high long-term survival rate. This operation method also has good clinical effect for selected cases of glottic laryngeal carcinoma T1b, T2 and T3.

Key words: Larynx neoplasm, Glottic cancer, Squamous-cell carcinoma, CO2 laser, Suspension laryngoscope

CLC Number: 

  • R739.65
[1] Hartl D M, de Mones E, Hans S, et al. Treatment of early stage glottic cancer by transoral laser resection[J]. Ann Otol Rhinol Laryngol, 2007, 116(11):832-836.
[2] Mota G, Esposito E, Motta S, et al. CO2 laser surgery in the treatment of glottic cancer[J]. Head Neck, 2005, 27(7):566-573.
[3] Bumber Z, Prgomet D, Janjanin S. Endoscopic CO2 laser surgery for supraglottic cancer—ten years of experience[J]. Coll Antropol, 2009, 33(1):87-91.
[4] Remacle M, Eckel H E, Antonelli A, et al. Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society 2000[J]. Eur Arch Otorhinolaryngol, 2000, 257(4):227-231.
[5] 王颖, 周佳青. CO2激光治疗早期声门型喉癌的研究进展[J]. 现代肿瘤医学, 2012, 20(7):1483-1486. WANG Ying, ZHOU Jiaqing. The progress of CO2 laser surgery in the early glottic cancer[J]. Modern Oncology, 2012, 20(7):1483-1486.
[6] 黄志刚, 韩德民, 于振坤, 等. 支撑喉镜下CO2激光喉部分切除最大范围的实验研究[J]. 中华耳鼻咽喉科杂志, 2004, 39(7):399-401. HUANG Zhigang, HAN Demin, YU Zhenkun, et al. Largest extension of laser surgery for laryngeal cancer in experimental animals[J]. Chin J Otorhinolaryngol, 2004, 39(7):399-401.
[7] Ledda G P, Puxeddu R. Carbon dioxide laser microsurgery for early glottic arcinoma[J]. Otolaryngol Head Neck Surg, 2006, 134(6):911-915.
[8] 胡艳红, 王东海, 李翔宇, 等. 早期声门型喉癌CO2激光术后复发相关因素分析[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(22):1774-1776. HU Yanhong, WANG Donghai, LI Xiangyu, et al. Evaluate the related factors of recurrence after carbon dioxide laser in treatment of early glottic carcinoma[J]. Clin J Otorhinolarynol Head Neck Surg, 2014, 28(22):1774-1776.
[9] 何发尧, 王跃建, 陈伟雄, 等. 早期声门型喉癌的CO2激光手术治疗[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(3):493-495. HE Fayao, WANG Yuejian, CHEN Weixiong, et al. Clinical research of early laryngocarcinoma treatment by carbon dioxide laser microsurgery[J]. Clin J Otorhinolarynol Head Neck Surg, 2014, 28(7):493-495.
[10] 王颖, 周佳青. CO2激光治疗早期声门型喉癌的Meta分析[J]. 临床耳鼻咽喉头颈外科杂志, 2012, 26(18):783-792. WANG Ying, ZHOU Jiaqing. Local recurrence of CO2 laser surgery for patients with early glottic carcinoma: a systematic review and meta-analysis[J]. Clin J Otorhinolarynol Head Neck Surg, 2012, 26(18):783-792.
[11] 黄志刚, 韩德民, 于振坤, 等. CO2激光手术治疗声门型喉癌疗效分析[J]. 中华耳鼻咽喉科杂志, 2002, 37(3):219-222. HUANG Zhigang, HAN Demin, YU Zhenkun, et al. Evaluate the curative effect of CO2 laser in treatment of glottic carcinoma[J]. Chin J Otorhinolarynol, 2002, 37(3):219-222.
[1] XU Wen, TANG Wei, YU Shaoqing, LI Shaohui, GE Rongming. Treatment of pharyngeal and laryngeal hemangiomas with pingyangmycin [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 62-64.
[2] HAO Yan, LI Dongcai, LAN Jianping.. Comparison of the curative effect of CO2 laser microsurgery and conventional microsurgery for vocal polyp resection. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(6): 68-70.
[3] XUE Jianjun. CO2 laser treatment of 18 cases of tongue base tumors. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 61-62.
[4] JIA Yanfeng, YANG Chunwei, SONG Fuchun, YANG Xiangli, WANG Lin, LIU Jixiang. Efficacy of CO2 laser combined with proton pump inhibitors in the treatment of recurrent vocal process granuloma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 106-109.
[5] WANG Xiaoyan, ZHENG Yanqing, ZHENG Hao, YE Qing. Bone ablation in middle ear with pulsed CO2 laser and Er:YAG laser: an experimental study. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 75-79.
[6] WANG Junguo, SHEN Xiaohui, QIAN Xiaoyun, DAI Yanhong, CHEN Feng, GAO Xia. Treatment of earlystage glottic cancer with CO2 laser [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(3): 19-21.
[7] XIE Zhinian, JI Changyou, CHEN Jichuan, WANG Yinan, GUAN Liqian,
LI Hongtao, ZHANG Min, YANG Junhui. The influence of pSilencer2.0cMetsiRNA on human cancer of larynx Hep2 cells growth [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(2): 5-7 .
[8] LI Guang-hao . Selective low position and horizontal tracheotomy in larynx neoplasm [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 325-326 .
[9] LI Xiao-yu,GUO Xing,LI Xiao-tian,LI Fu-cai,GUAN Chao,YANG Huai-an,YU He,REN Zhong . Expression of gene BRMS1protein in supra-glottic laryngeal carcinoma and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(6): 481-483 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd