The study of cognitive disorderin patients with obstructive sleep apnea hypopnea syndrome.
- ZHU Yue, HUANG Zhichun, YANG Ming, ZHU Xin
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(5):
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Objective Using Neurocognitive function scalesto evaluate the changes of cognitive function in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). And analyzing the cognitive disorderin patients by the polysomnography(PSG). Methods A collection of 55 patients with OSAHS and 27 cases of normal control group, collecting their PSG results and related cognitive function to assess cognitive damage in patients with OSAHS. Analysisof the correlation between parameters associated with the PSG, and the parameters associated with impaired cognitive function best bound values. Results (1) There were no significant differences in gender, age and level of education(P>0.05); 山东大学耳鼻喉眼学报30卷5期 -朱越,等.阻塞性睡眠呼吸暂停低通气综合征患者认知功能损害的研究 \=-(2) There weresignificant differences in AHI, apnea index between the two groups, the longest time of apnea, low ventilation index, ODI, TST < 0.9, MSaO2, LSaO2(all P<0.05); (3) There were no significant differences in sleep structure comparison and total sleep time(P>0.05); (4) There were significant differences in MMSE scale results, including directional force(P<0.05); (5) There were significant differences in ESS, STOP Bang, LMT, LMT DR(P<0.05); (6) Neurocognitive function scale and PSG related parameters of the correlation of the results show that the AHI and apnea index are the strongest correlation between neurocognitive function scale; The longest time of apnea, low ventilation index, ODI, TST < 0.9, MSaO2 and LSaO2 has certain correlation with the scale, and number of awakening and snoring is no significant correlation; (7) MMSE standard for cognitive dysfunction screening validity comparison, results show that the AUC is 0.664. When the boundary value of 29.5, the Youden index is highest, about 0.32, and the sensitivity is 76.4%, while the specificity is 55.6%; (8) PSG validity screening, the best boundary value analysis of the parameters. The results showed that the best of apnea index value is 5.15, the longest apnea time the best value is 105 seconds, hypoventilation index the best value is 0.55, ODI the best value is3.1,TST < 0.9 the best value is 0.27%, MSaO2 the best value is 96.5%, and LSaO2 best value is 81.5%. Conclusions (1) Patients with OSAHS have low ventilation and apnea at night, leading to the occurrence of cognitive dysfunction; (2) There were no significant differences in sleep structure and total sleep time; (3) Cognitive function in patients with OSAHS exist different degree of damage, and is closely related to the severity of disease; (4) Directional force, logical memoryand memory ability in cognitive function in patients with OSAHS are impaired obviously; (5) Apnea index > 5.15, and(or)the longest apnea time > 105 seconds, and(or)apnea-hypopnea index > 0.55, and(or)ODI > 3.1, and(or)TST < 0.9 > 0.27%, and(or)MSaO2 < 96.5%, and(or)LSaO2 < 81.5%, can quickly promptclinical doctors OSAHS patients that may have impaired cognitive function.