Abstract: Objective To explore the value of 3D technology for accurate treatment of transnasal endoscopic nasal skull base neoplasm resection and the functional reconstruction of the nasal skull base surgery. Methods A total of 21 cases of nasal skull base neoplasm were carried out sinus coronal CT/MRI scan parallel 3D reconstruction and 3D printing. The invasion scope of the nasal skull base neoplasm and the size/shape of the bony defect of the skull base and orbital wall were read according to 3D reconstruction and 3D model, then the surgery path and the accurate resection range and the accurate reconstruction method were determined. Results All patients neoplasm had been removed in the first operation. 6 cases had been performed accurate functional reconstruction of the skull base surgery without cerebrospinal fluid(CSF)leak and intracranial infection happened. Post-operative pathology indicated that there were 9 cases of squamous cell carcinoma, 5 esthesioneuroblastoma, 3 adenoid cystic carcinoma and 4 rhabdomyosarcoma. Patients accepted radiotherapy after surgery. Within a follow-up of 36 months on average, no neoplasm relapsed and no death that is connect whit the neoplasm appeared. Conclusion 3D reconstruction and 3D model could show the invasion scope of the nasal skull base neoplasm and the size/shape of the bony defect of the skull base and the orbital wall clearly. Also 3D reconstruction and 3D model could help surgeons to make the best operative schemes. 3D imaging and 3D printing technology has important guiding significance for accurate treatment of transnasal endoscopic nasal skull base neoplasm resection and the functional reconstruction of the nasal skull base surgery.

Key words: Nasal skull base neoplasms, Transnasal endoscopic surgical procedures, operative, Accurate treatment, Three-dimensional technology