Table of Content

16 December 2016 Volume 30 Issue 6

  

Analysis of blood lipids in patients with sudden sensorineural hearing loss.

LIU Yangyun, ZHANG Caixia, JIANG Wen, CHEN Qiong, CHANG Enge, ZHAO Huaxiang, YAN Hui

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  1-4.  doi:10.6040/j.issn.1673-3770.0.2016.062

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Objective To explore the correlation between blood lipids and sudden sensorineural hearing loss(SSHL), in order to provide preventive measures. Methods A total of 68 SSHL cases(SSHL group)and 80 non-SSHL cases(control group)were enrolled. The level of total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), apolipoprotein A(Apo-A)and apolipoprotein B(Apo-B)in the two groups of patients were measured and compared. Results There was statistical difference in the level of TG between the two groups(P<0.05), while there was no statistical difference in the other indicators(P>0.05). There was no statistical difference in the blood lipids between patients with different curves of audiology and patients with various degrees of hearing loss(P>0.05). Conclusion Increased TG level is related to the occurrence of the SSHL. Controlling the level of TG may help to prevent SSHL.

Treatment of residual tinnitus after threshold recovery of low frequency sudden deafness: a report of 129 cases.

ZHU Jiangbin, NAN Bingwei, CHEN Tao, HAO Zongsheng

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  5-7.  doi:10.6040/j.issn.1673-3770.0.2016.082

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Objective To investigate the treatment and efficacy of residual tinnitus after the recovery of threshold of low frequency sudden sensorineural hearing loss. Methods Shuxuening injection, prednisone acetate tablets, Gastrodia elata injection, lidocaine injection, hydroch-lorothiazide tablets and mecobalamin injection were used in combination for 10 days. The curative effect was observed. Results The treatment yielded good curative effect: the total effective rate was 93.13%, and the cure rate was 66.41%. After 1-year follow-up, the total effective rate was 93.33%, and the cure rate was 63.81%. Conclusion The combined use of drugs is effective. All drugs are cheap, and there is few side-effect.

Surgical experience of otitis media in patients with one hearing ear only.

DU Lijun, TONG Jun, CHEN Wenwen, DENG Yaxin, CAI Xunhua, SHAN Liang

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  8-10.  doi:10.6040/j.issn.1673-3770.0.2015.435

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Objective To summarize the surgical experience of otitis media, as well as cholesteatoma of the middle ear, in patients with one hearing ear only. Methods A total of 13 patients with otitis media underwent operation between May 2000 and Jan 2013. The surgical and follow-up data were retrospectively collected and compared with those of 15 patients(as pre-group )who received surgical treatment before 2000. Results All patients achieved dry ear after follow-up(ranged from 6 months to 156 months, averaged follow-up was 84.55±56.84 months). The A-B GAP and air conduction(AC)were dropped after treatment compared with those before operation(P<0.01). The overall effective rate of operation was 92.31 %( 12/13). In those with successful operation, 4 case with GAP<10 dB HL, 7 cases with GAP between 11 and 20 dB HL, there was no significant difference in bone conduction(BC)before and after treatment(P>0.05). The proportion of patients with GAP difference over 20 dB HL and 30 dB HL were 76.92%(10/13)and 30.77%(4/13), which was significant higher than those of 40.00%(6/15)and 13.33%(2/15)in pre-group. Conclusion This study shows a more safe and effective outcome in surgical treatment otitis media in patients with one hearing ear only.

The clinical manifestations of posterior semicircular canal benign paroxysmal positional vertigo at the time of acute onset.

LIU Xuesheng, LI Xiaoyu, DENG Wei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  11-13.  doi:10.6040/j.issn.1673-3770.0.2015.486

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Objective To observe and summarize the clinical characteristics of posterior semicircular canal benign paroxysmal positional vertigo(PSC-BPPV)at the time of acute onset, and to provide the clinical evidences for earlier diagnosis. Methods The clinical manifestations at the time of acute onset of 115 cases of patients with PSC-BPPV diagnosed were collected retrospectively. The gender, distributions of age, character of dizziness, state of patients at the time of acute onset, relationships between vertigo attack and head movement, nystagmus, associated symptoms, and auxiliary examination were analyzed. Results The clincal characteristics of PSC-BPPV at the time of acute onset were summarized as follow:(1) incidence among female patients was more higher than that of male patients; (2) participants aged over 50 years-old were more vulnerable to be affected;(3) acute vertigo occurred mainly at time of getting up, lying down, turning over or moving head actively or passively to a certain position, especially getting up in the morning; (4) the onset of severe vertigo was associated with nausea and vomitting; (5) part of patients presented characteric rotatory nystagmus of PSC-BPPV at the time of initial routine physical examination; (6) without symptoms and signs of cochlear and nervous system; (7) without related positive findings by cranial imaging(CT or MRI). Conclusion The diagnosis of PSC-BPPV should be considered if patients presented vertigo attack suddenly but without symptoms and signs of coclear and nervous system and related positive findings by cranial imagings. It is helpful to earlier confirming of the diagnosis by performing Dix-Hallpike manuvre.

Vestibular function damage mechanisms in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy.

LIU Ye, SUN Dianshui, YIN Jinjun, XIA Ming, XU Ying, SUN Jianhua

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  14-17.  doi:10.6040/j.issn.1673-3770.0.2016.105

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Objective To explore potential mechanisms of vestibular function damage in nasopharyngeal carcinoma(NPC)patients after intensity-modulated radiotherapy(IMRT). Methods Patients who received radical IMRT for their NPC were recruited. The serum levels of IL-6 and IL-17 were detected with ELISA method. Vestibular evoked myogenic potential(VEMP)tests were used to evaluate vestibular function and correlation analyses were used to analyze the potential mechanisms of vestibular function damage. Results Thirty-eight patients were included. The mean and maximum radiation doses to the inner ears were both significantly associated with abnormal ocular VEMP(oVEMP)and cervical VEMP(cVEMP)(P<0.05, all), but the correlations were all mild. There were no significant correlations between otitis media(OM)and abnormal oVEMP and cVEMP(P>0.05). The serum levels of IL-6 and IL-17 in NPC patients both increased and were significantly associated with abnormal oVEMP and cVEMP after irradiation(P<0.05, all). Conclusion The radiation doses to the inner ears were associated with the incidence of vestibular function damage, but the correlations were mild. OM had no relations with the incidence of vestibular function damage in present study. The inflammatory responses and possible resolution obstacles of inflammation participated in persistent vestibular function damage after irradiation.

A systematic review of surgical timing of traumatic facial paralysis.

XIE Shaobing, ZHANG Yanni, XU Zhenhang, ZHANG Jianhui, WU Xuewen, SUN Hong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  18-21.  doi:10.6040/j.issn.1673-3770.0.2016.160

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Objective To review the timing of surgical decompression. Methods Databases including Pubmed, EMBASE, Cochrane, CNKI, Wanfang database and Weipu database were searched to collect studies on surgical timing of traumatic facial paralysis which were published from the inception of databases to March 2016. The surgical timings were classified into 4 groups: <2 weeks, 2 weeks~1 month, 1-2 months and >2 months. Results A total of 8 studies involving 145 patients(145 cases)were included. Of all patients, 56(38.6%)achieved complete recovery(House-Brackmanm, H-B Ⅰ). Good results(H-B Ⅰ and Ⅱ)were achieved in 96.8%(30/31)patients who received surgery within 2 weeks versus 64.9%(74/114)patients who received surgery after >2 weeks, showing a statistical difference(P<0.001). Conclusion The ideal timing of surgical decompression for traumatic facial paralysis is within 2 weeks after trauma. Surgical intervention performed within 2 months results in good clinical prognosis.

Efficacy of sodium bicarbonate and fluconazole in the treatment of fungal otitis externa.

SHEN Li

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  22-23.  doi:10.6040/j.issn.1673-3770.0.2016.178

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Objective To explore the clinical efficacy of sodium bicarbonate combined with fluconazole in the treatment of fungal otitis externa. Methods Using random parallel control method, 105 patients with fungal otitis externa were divided into three groups: the treatment group(ear bath with sodium bicarbonate plus fluconazole injection); control group 1(ear bath with fluconazole injection); control group 2(ear bath with 2% salicylic acid alcohol), with 35 cases in each group. The treatment lasted for 10 days. The patients were followed up for one year to observe the curative effect. Results The total effective rate of the 3 groups were 91.43%, 85.71%, and 77.14%. The efficacy of the treatment group was better than that of the control groups(P<0.05). Conclusion Sodium bicarbonate combined with fluconazole is better than 2% salicylic acid alcohol or fluconazole alone in the treatment of fungal otitis externa.

3D technology for accurate treatment of transnasal endoscopic nasal skull base neoplasm resection and the functional reconstruction.

WU Jian, FAN Jingping, LIU Huanhai, LANG Juntian, LU Xiaoqing, XU Yaping

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  24-28.  doi:10.6040/j.issn.1673-3770.0.2016.253

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Objective To explore the value of 3D technology for accurate treatment of transnasal endoscopic nasal skull base neoplasm resection and the functional reconstruction of the nasal skull base surgery. Methods A total of 21 cases of nasal skull base neoplasm were carried out sinus coronal CT/MRI scan parallel 3D reconstruction and 3D printing. The invasion scope of the nasal skull base neoplasm and the size/shape of the bony defect of the skull base and orbital wall were read according to 3D reconstruction and 3D model, then the surgery path and the accurate resection range and the accurate reconstruction method were determined. Results All patients neoplasm had been removed in the first operation. 6 cases had been performed accurate functional reconstruction of the skull base surgery without cerebrospinal fluid(CSF)leak and intracranial infection happened. Post-operative pathology indicated that there were 9 cases of squamous cell carcinoma, 5 esthesioneuroblastoma, 3 adenoid cystic carcinoma and 4 rhabdomyosarcoma. Patients accepted radiotherapy after surgery. Within a follow-up of 36 months on average, no neoplasm relapsed and no death that is connect whit the neoplasm appeared. Conclusion 3D reconstruction and 3D model could show the invasion scope of the nasal skull base neoplasm and the size/shape of the bony defect of the skull base and the orbital wall clearly. Also 3D reconstruction and 3D model could help surgeons to make the best operative schemes. 3D imaging and 3D printing technology has important guiding significance for accurate treatment of transnasal endoscopic nasal skull base neoplasm resection and the functional reconstruction of the nasal skull base surgery.

Application of three-dimensional printing technique in assisting reconstruction after maxillectomy.

WU Kunmin, WU Jian, LI Zeqing, CHEN Wei, ZHU Chunhui, YANG Qi

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  29-32.  doi:10.6040/j.issn.1673-3770.0.2016.368

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Objective To investigate the application and clinical outcomes of 3-Dcomputer-assisted printing technique in the surgical treatment of malignant tumors of maxillary sinus. Methods Five patients suffering from malignant tumors of maxillary sinus received total maxillectomy were included in this study. Before operation, a three-dimensional individual stereo-maxillary model based on mirror images of the unaffected maxilla was obtained to fabricate an anatomically adapted titanium mesh using computer-assisted design and manufacturing. The individual titanium mesh was inserted into the maxillary after total maxillectomy. Facial appearance and function were evaluated by clinical and CT examinations. Results All patients were satisfied with their postoperative facial symmetry and did not develop diplopia or endophthalmos. During the operation procedure, the pre-bent titanium mesh did not require reshaping and pruning. The implanted titanium mesh fit bone bed surrounding the defect closely. Clinical and CT examinations showed recurrence in none during the follow-up of 8 to 30 months. Conclusion With good feasibility and reliability, 3-dimensional printing technique is suitable for the surgical treatment of maxillary sinus malignant tumors, and can significantly improve the clinical outcome.

Combined middle meatus and prelacrimal recess approach for treatment of fungal maxillary sinusitis.

KANG Zonghui, XIA Siwen, HU Xianhui, CHEN Chunxiao, ZHENG Yingsong, HUANG Yideng

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  33-36.  doi:10.6040/j.issn.1673-3770.0.2016.198

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Objective To explore the indication and efficacy of middle meatus and prelacrimal recess approach under endoscopy for fungal maxillary sinusitis. Methods The clinical data of 32 patients with fungal maxillary sinusitis hospitalized in June 2008 to June 2014 were retrospectively analyzed. The indication and curative effect and complications were analyzed during the follow-up. Results Maxillary fungus was thoroughly removed. All patients were followed up over one year and a half. No complications and recurrence were found. Conclusion The endoscopic middle meatus and prelacrimal recess approach for fungal maxillary sinusitis has advantages of clear view, complete exposure of maxillary wall and high therapeutic effect. It can be used as a preferable method when the maxillary mycoses can not be completely removed via endoscopic middle meatal and/or combined inferior meatal approach.

Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea: a clinical analysis of 16 cases.

WANG Junmin, CHEN Haibing, CHEN Xi, LU Meiping, CHEN Zhibin, CHENG Lei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  37-41.  doi:10.6040/j.issn.1673-3770.0.2016.377

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Objective To evaluate the surgical technique and clinical effects of transnasal endoscopic repair of cerebrospinal fluid(CSF)rhinorrhea. Methods From 2010 to 2015, sixteen patients with CSF rhinorrhea were treated with transnasal endoscopic surgery, including 5 patients with traumatic CSF rhinorrhea, 6 patients with spontaneous CSF rhinorrhea, and 5 patients with iatrogenic CSF rhinorrhea. The temporalis muscle, temporalis fascial, middle turbinate mucosa and bone, nasal septum mucosa, inferior turbinate mucosa, fascia lata, abdominal fat, and uncinate process mucosa were used for repairing the CSF fistulae. Results Fifteen patients were successfully repaired after the first operation, and 1 after the second attempt. No serious complications were observed during and after the operation. Conclusion Transnasal endoscopic repair of CSF rhinorrhea is a safe, effective, minimally invasive, and high successful surgical procedure. Accurate leakage site identification before the operation, suitable surgical approach and repairing materials are critical to achieving successful result.

The treatment experience on osteoradionecrosis of skull base with nasopharyngeal carcinoma after radiotherapy.

WANG Yaning, GENG Bo, LI Baiyan, CUI Chaoyang, WANG Qirong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  42-45.  doi:10.6040/j.issn.1673-3770.0.2016.076

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Objective To investigate the clinical treatment strategies of osteoradionecrosis of skull base(ORN)in the patients with nasopharyngeal carcinoma(NPC)after radiotherapy. Methods All patients(n=11)diagnosed as NPC and osteoradionecrosis of the skull base were studied retrospectively with their clinical manifestations, diagnoses, therapies and prognoses. Results In the NORN group, 2 cases died of intracranial and lung infections respectively1year after the treatment. Out of the 5 survivors, 3 was in the stationary state(one was followed up five years,1 three years and 1 one year)and the other 2 were presented with repeated infection and expansion of the osteoradionecrosis lesion(one was followed up one year, one eight months). In the TORN group, 3 patients had localized necrosis, of which one had complete epithelialization(followed up 3 years)and two had continuous seepage( followed up 1 and 3 years separately), and they were not presented with expansion of the osteoradionecrosis lesion. The last patient died of massive expistaxis due to internal carotid blowout. Three patients of the group executed responsibility vascular embolization. Conclusion For ORN, early and complete clean up of the necrotic tissue by endoscopy is an effective method. Responsibility vascular embolozation can not only avoid excessive bleeding and reduce mortality, but also reduce the operation risk and thoroughly clean the necrosis.

Application of sternocleidomastoid flaps in the resection of benign parotid tumors.

ZHOU Changhua, GUI Mingcai, XU Dan, LIU Bo

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  46-48.  doi:10.6040/j.issn.1673-3770.0.2016.004

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Objective To investigate the application effect of sternocleidomastoid flaps in the resection of benign parotid tumors. Methods Eighty-four patients with benign parotid tumors were randomly divided into control group(n=42)and experimental group(n=42). The patients in control group were treated with traditional parotidectomy, while those in experimental group with sternocleidomastoid flap transferred to fill sunken operative area for repair after routine resection of parotid lesions. The follow-up was 6-12 months. The incidence of postoperative complications and tumor recurrence rate were compared in two groups. Results The incidence of postoperative complications in experimental group(14.29%)was significantly lower than that in control group(52.38%), and the difference was statistically significant(P<0.01). There was no statistical significance between two groups by comparison to the tumor recurrence rate(P>0.05). Conclusion Application of sternocleidomastoid flaps in benign parotid tumors to repair the sunken operative area can effectively reduce the risk of complications and the surgical effect isnt impacted, so it is worthy of promotion.

Comparison of three surgical methods in adult patients undergoing tonsillectomy.

XU Lei, ZHU Juanfen, CHENG Lei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  49-52.  doi:10.6040/j.issn.1673-3770.0.2016.401

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Objective To compare and analyze the clinical application value of three surgical methods in adult patients undergoing tonsillectomy. Methods Ninety patients who received tonsillectomy were divided into coblation tonsillectomy(coblation group, n=30), electrocautery tonsillectomy(electrocautery group, n=30), and conventional tonsillectomy(conventional group, n=30). The duration of the entire operation, amount of intraoperative and postoperative bleeding, postoperative sore throat assessed using a visual analogue scale(VAS), and hospital costs were all recorded in three groups. Results Significant difference was shown among three groups by comparison to the operation time, amount of blood loss and the VAS scores of postoperative pain 1-4 d after surgery(P<0.001), in which the above indexes of coblation group and electrocautery group were all superior to those of conventional group(P<0.001), but there was no statistical significance between coblation group and electrocautery group(P>0.05). One patient encountered primary hemorrhage after surgery in conventional group, whereas no postoperative hemorrhage in coblation group and electrocautery group. There was no statistical significance among three groups by comparison to the nursing and examination/treatment expenses as well as postoperative charges for medicine(P>0.05). The total hospital cost in electrocautery group and conventional group was obviously lower than that in coblation group(P<0.001), but no significant difference was shown between electrocautery group and conventional group(P>0.05). Conclusion Each of the three surgical methods in adult tonsillectomy has its own advantages and disadvantages. In the clinical practice, the most appropriate surgical method should be selected so as to achieve the optimal therapeutic effect based on the disease characteristics, willingness and economic capability of patients, technical level of surgeons and medical instruments.

Resection of benign gloss-epiglottis lesions assisted with video laryngoscope and radiofrequency ablation system: a report of 71 cases.

LI Shuhua, SHI Hongjin, WU Dahai, HEI Renyi

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  53-57.  doi:10.6040/j.issn.1673-3770.0.2016.118

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Objective To explore the feasibility of resecting benign gloss-epiglottis lesions assisted with video laryngoscope and radio frequency plasma system, and to summarize the indications and operative methods. Methods Patients with benign gloss-epiglottis lesions were prospectively enrolled in this study during Jan. 2014 and June 2015. The lesions were resected with assist of video laryngoscope and radiofrequency ablation system in patients with lingual base papilloma, lingual tonsillar hypertrophy and epiglottis cyst. All patients were followed up, and therapeutic effects and complications were recorded. Results A total of 71 patients were enrolled, including 44 with epiglottis cyst, 17 with lingual base papilloma and 10 with lingual tonsillar hypertrophy. After general anaesthesia with tracheal intubation stabilization, all operations were conducted with assist of video laryngoscope and radiofrequency ablation system. All patients recovered well, except 2 patients who developed tardive postoperative hemorrhage. No other complications occurred. During the 6-18 month follow-up, no recurrence was observed. Conclusions Lesion ectomy with assist of video laryngoscope and radiofrequency ablation system is safe, simple, mini-invasive, and effective, which offers good exposure and wide field, and achieves a high local control and low surgical complication rate.

Diagnosis and treatment of thyroid abscess and parapharyngeal space abscess caused by acute tonsillitis: a case report and literature review.

SUN Zhenfeng, ZHANG Jia, SU Tiantian, DONG Pin

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  58-60.  doi:10.6040/j.issn.1673-3770.0.2016.220

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Objective To analyze the etiology, route of infection, and treatment of a thyroid abscess caused by acute tonsillitis, which finally resulted in parapharyngeal space infection. Methods According to CT results, the site was incised laterally to reveal the neck space thoroughly. After that, the abscess was drained and rinsed carefully. Results The patients temperature lowered day by day, and the patient recovered after 10 days. Conclusion B ultrasound combined with enhanced CT is an effective means for the identification of neck cyst and abscess. Puncture pathological examination is the gold standard for diagnosis. If oral or maxillofacial infections are concurrent with thyroid cyst, special attention should be paid to abscess formation. Lateral neck incision, adequate irrigation and drainage are effective means to treat pharyngeal space abscess.

CO₂ laser treatment of 18 cases of tongue base tumors.

XUE Jianjun

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  61-62.  doi:10.6040/j.issn.1673-3770.0.2015.463

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Objective To explore the therapeutic effect of CO₂ laser in the treatment of tongue base tumors. Methods A total of 18 cases of tongue base tumors were surgically removed with CO₂ laser, including 8 cysts, 5 hemangiomas, 3 papillomas, and 2 thyroglossal cysts. Results All operations were successful. Bleeding occurred in 1 case on the second day after operation, and then stopped after symptomatic treatment. After 1-month follow-up, 13 cases were cured, 3 cases were relieved, and 2 cases remained unchanged, which relapsed 5 and 7 months after surgery, received a second CO₂ laser surgery, and then no recurrence was observed. Conclusion CO₂ laser is effective in the treatment of tongue base tumors, which causes little intraoperative bleeding.

Report of 11 cases of Kimuras disease and review of literature.

JIN Chengxun, ZHAO Xue, LIU Yue, WEI Ning, JIN Chunshun

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  63-66.  doi:10.6040/j.issn.1673-3770.0.2016.094

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Objective To explorethe clinical signs,symptoms,pathological and laboratory examinations, diagnosis, differential diagnosis and treatmentof Kimuras disease. Methods Clinical data of 11 cases of Kimuras disease were retrospectively reviewed. The characteristics of laboratory and pathological examinations were summarized. The efficacies of surgical treatment and expectant treatmentwere compared. Results All patients were male, aged 39 years on theaverage.The location of the disease was preauricular, retroauricular, neck andsubmaxillay. Theclinical manifestations were painless progressive swelling. Pathologic characteristics were massivelymphadenosis, with the formation of lymphoid folliculars, and eosinophil infiltration. Laboratory examinationsshowed increased peripheral blood eosinophilia, and elevated serum IgE. Conclusion The diagnosis of Kimuras disease is mainly based on clinical manifestations, laboratory and pathological examinations. As the disease is rare, with no specific clinical manifestations, chronic onset, and duration long, misdiagnosis is likely to occur. Kimura disease through or Hormone therapy, radiotherapyand surgery can be adopted to treat this disease.

Changes of tear film and tear secretion in patients before and after pterygial excision combined with conjunctival autografts.

DAI Lihua, GUO Xia, ZHANG Jingjing

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  67-69.  doi:10.6040/j.issn.1673-3770.0.2016.117

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Objective To evaluate the changes of tear film and tear secretion in patients before and after pterygial excision combined with conjunctival autografts. Methods Tear break-up time(BUT), SchirmerⅠtest(SⅠ)and corneal fluorescein staining(FL)were evaluated in 65 eyes of 65 patients suffered from pterygium 3 days before operation, and 7 days, 1 month, and 3 months after pterygial excision combined with conjunctival autografts. Results The results of BUT and FL were significantly different before and after pterygial excision(P<0.05). No significant difference was found in SⅠ before and after surgery(P>0.05). Conclusion Pterygial excision combined with conjunctival autografts can partly restore the ocular surface in patients with pterygium.

Influence of TransPRK and LASEK on postoperative vision, diopter and corneal biomechanical properties in myopic eyes with thin cornea.

LIU Wenjing

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  70-74.  doi:10.6040/j.issn.1673-3770.0.2015.502

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Objective To explore the Influence of TransPRK and LASEK on postoperative vision, diopter and corneal biomechanical properties in myopic eyes with thin cornea. Methods Totally 118 patients with myopia and astigmatism were enrolled, in which data of 118 right eyes were selected and analyzed, 61 eyes of 61 patients undergoing TransPRK were designed as TransPRK group, and 57 eyes of 57 patients undergoing LASEK as LASEK group. The uncorrected visual acuity(UCVA), diopter, central corneal thickness(CCT), posterior corneal surface height, aspheric parameter Q value, corneal hysteresis(CH), corneal resistance factor(CRF)and corneal aberration between two groups were compared 1 week, 1 month, 3 months, and 6 months after operation. Results There were no statistical difference between two groups regarding the proportion of postoperative UCVA reaching or exceeding preoperative best corrected visual acuity(BCVA)one week, 1 month, 3 months, and 6 months after operation. The proportion of patients’ diopter reaching or exceeding preoperative desired diopter correction was higher in TransPPK than LASEK group 1 week and 1 month after operation(P<0.05). Compared with pre-operation, the posterior corneal surface height shifted rearward slightly(P<0.05), but aspheric parameter Q value didnt change significantly(P>0.05)in postoperative 6 months in the two groups. The CH, and CRF value on postoperative 1, 3 and 6 months were significantly lower than pre-operation in two groups(P<0.05). The coma aberration, spherical aberration, and higher order aberration after postoperation were higher than pre-operation(P<0.01), but there was no significant difference between two group regarding CH, CRF, coma aberration, spherical aberration, and higher order aberration at each time point after operation. Conclusion TransPPK, as emerging surface refractive surgery, is effective and safe in treating myopic eyes with thin cornea, with stable diopter, for it is operated not on the eyeball and has little effect on the corneal surface morphology and biomechanical properties.

Distribution of corneal astigmatism among middle aged and senior citizens with cataract.

LIU Lu, LIANG Hao

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  75-77.  doi:10.6040/j.issn.1673-3770.0.2016.059

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Objective To study the distribution of corneal astigmatism among middle aged and senior citizens with cataract. Methods The gender, age, nation, corneal astigmatism,minimum value of corneal curvature and maximum value of corneal curvature of 489 cataract patients(630 eyes)from First Affiliated Hospital of Guangxi Medical University between July 2014 and October 2015 were collected, and the patients were divided into groups according to their gender, age, eyes and astigmatism type. Results The subjects in this study were aged between 47 and 98 years, among whom 234(302 eyes)were male and 255(328 eyes)were female. The astigmatic power were bigger than 2.00 D in 32 eyes(5.08%), between 1.01D and 2.00 D in 175 eyes(27.78%), and smaller than 1.00 D in 423 eyes(67.14%). The astigmatic power was positively correlated with the age(r=0.193, P=0.020). With-the-rule astigmatism was found in 240 eyes(38.10%),against-the-rule astigmatism in 360 eyes(57.14%), and oblique astigmatism in 30 eyes(4.76%). With the increase of age, the portion of with-the-rule astigmatism became smaller, the portion of against-the-rule astigmatism became bigger, but no definite trend was found for oblique astigmatism. Conclusion With the increase of age, the corneal astigmatism in cataract patients has an increase trend, and with-the-rule astigmatism gradually changes into against-the-rule astigmatism.

Expression of endothelin-1 in plasma of patients with hypertensive retinopathy in essential hypertension.

CHEN Xuan, HAN Li, FAN Chuanfeng, LI Yingmei, LIU Jian, SHU Xiangwen, WANG Yu

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  78-80.  doi:10.6040/j.issn.1673-3770.0.2016.066

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Objective To investigate the expression of endothelin-1(ET-1)in patients with hypertensive retinopathy(HRP)and to evaluate the association between ET-1 level and HRP. Methods A total of 120 essential hypertensive patients with HRP, including 60 patients with grade I HRP and 60 with grade II HRP, were recruited. Sixty healthy subjects were selected as control group. The concentration of ET-1 was measured by enzyme-linked immunoassay technique. The relationship of HRP and ET-1 was analyzed. Results The level of ET-1 was(46.4±10.8),(80.9±13.2)and(98.6±11.7)pg/mL in control, grade Ⅰ HRP and grade Ⅱ HRP groups respectively, which increased sucessively, and there was statistical significance among three groups(F=296.54, P=0.029). Conclusion ET-1 level anomalies are related with hypertensive retinopathy.

Research progress of Fascin-2 gene function.

YANG Linlin, SONG Xicheng, HAN Fengchan

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  81-84.  doi:10.6040/j.issn.1673-3770.0.2015.358

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Fascin-2 gene, an actin cross-linking protein found in membrane ruffles, microspikes, and stress fibers, controls the parallel, sequential, and tight alignment and aggregation of actin filaments. Recent researches have found that Fascin-2 gene is associated with the cilia of plasma membrane, whose basic composition is actin; Fascin-2 gene plays an important role in the formation of photoreceptor disk and stereocilia; the mutation of Fascin-2 gene may cause progressive retinitis pigmentosa and hearing loss. This paper will elucidate the latest research progress on Fascin-2 gene.

Laryngopharyngeal reflux and otorhinolaryngology diseases

SUN Na, CHEN Xiaoping

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  85-89.  doi:10.6040/j.issn.16733770.0.2016.213

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Laryngopharyngeal reflux is one of the major causes of respiratory symptoms related to pharyngeal foreign body sensation, hoarseness and other symptoms of the upper respiratory tract. It is becoming a hotspot of otolaryngologists. At present, there are still a lot of controversies about the diagnosis and treatment of laryngopharyngeal diseases, such as sinusitis, otitis media, sleep apnea hypopnea syndrome, and so on. Now experts on throat diseases are working on a standardized diagnosis, treatment and efficacy evaluation system and carrying out multicenter clinical researches, in order to normalize the diagnosis and treatment of laryngopharyngeal reflux.

Discussion on the relationship between vocal cord leukoplakia and premalignant lesions and research progress of vocal cord leukoplakia.

WANG Yalin, CHEN Jianqiu

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  90-93.  doi:10.6040/j.issn.1673-3770.0.2016.061

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Vocal cord leukoplakia is a white-plaque disease due to long-term stimulation on vocal cords, which includes abnormal epithelial hypertrophy and dysplasia of the vocal cord. The term “white plaque” is clinically describing any white lesion on a mucous membrane that cannot be wiped off or ascribed to any specific condition(eg, Candidal infection). There is a consensus that vocal cord leukoplakia has no histologic implications and synonymous with cancer or malignancy, only as a clinical descriptive diagnosis. In this paper, we reviewed the relationship between vocal cord leukoplakia and premalignant lesions and the formation mechanism, histopathologic classification, clinical diagnosis and treatment of vocal cord leukoplakia.

Research advances on the assessment and influencing factors of glaucoma patients’ quality of life.

YANG Hongling

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  94-97.  doi:10.6040/j.issn.1673-3770.0.2016.308

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In this paper, we reviewed the relevant studies on glaucoma patients’ quality of life, including glaucoma-related concepts, status of quality of life, assessment instruments and influencing factors. At present, there are no sufficient assessment instruments available, and nor comprehensive studies on the psychological and social factors which can affect quality of life. In addition, clinical interventions still need to be validated. Therefore, specific assessment instruments should be developed to explore the influencing factors of quality of life in large-sample and multicentric studies.

Construction and application of the teaching case database of otolaryngology head and neck surgery.

YANG Jingpu, ZHANG Dejun, ZHAO Yin, CHENG Jinzhang, ZHAO Xue, LIU Yan, YU Dan, WANG Haitao, WEN Lianji

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  98-100.  doi:10.6040/j.issn.1673-3770.0.2016.021

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Case teaching is a teaching method that can improve students’ analytical ability. The construction of case database can support case teaching and its orderly development, including the following steps: collecting clinical data, systemizing the teaching syllabus and targets, and finalizing. The database includes subjects on otology, nasology, throat, head and neck cancer surgery. Each case includes general information, complaints, history, symptoms, physical examinations, auxiliary examinations, diagnosis, treatment and follow-up. And the corresponding search term is selected. Cases are divided into introduction and improvement ones, or typical and atypical ones. The contents of database are constantly revised to make them more suitable for the teaching of clinical postgraduates.

Treatment of huge cholesteatoma in the petrous apex by microscope combined with otoendoscope: report of 1 case.

ZHU Lin, ZHANG Dejun, GUAN Guofang, GUO Yingyuan

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  101-103.  doi:10.6040/j.issn.1673-3770.0.2016.345

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Histopathologic analysis of 81 cases of parotid malignant tumor.

ZENG Wanting, CHEN Yanren, TAN Yun, LI Te, ZHANG Min, GUAN Liqian, CHEN Jichuan, JI Changyou, LIU Rongrong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  104-106.  doi:10.6040/j.issn.1673-3770.0.2016.027

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The diagnosis and treatment of throat syphilis in 3 cases.

ZHANG Youfen, WEN Lianji, YU Dan, LIU Yan, JIN Chengxun, TAN Yue, HAN Shuang

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  107-108.  doi:10.6040/j.issn.1673-3770.0.2016.139

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Treatment of acute epiglottitis with sudden asphyxia by cricothyroxectomy: a report of 5 cases.

LIU Hongchuan, XIE Fanglan

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  109-110.  doi:10.6040/j.issn.1673-3770.0.2016.326

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One case of Von Hippel-Lindau syndrome.

WANG Hui, WANG Jialin, WANG Yanling

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  111-112.  doi:10.6040/j.issn.1673-3770.0.2016.229

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Giant polymorphic adenoma involving the nasal and pharyngeal spaces in one case.

ZHU Huitao, CAI Xiaolan, QI Junjun, ZHANG Jinling, LI Xuezhong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  113-114.  doi:10.6040/j.issn.1673-3770.0.2015.445

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Sinonasal terato carcinosarcoma: one case report.

LÜ Dan, YANG Hui, ZHANG Xiaoxiong, XIAN Junming, XU Ting, YU Rong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  115-116.  doi:10.6040/j.issn.1673-3770.0.2016.005

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Epithelioid hemangioendothelioma of the nasal cavity: one case report.

CHEN Yanli, ZHANG Maohua, LI Huifeng, LIU Jiewei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  117-119.  doi:10.6040/j.issn.1673-3770.0.2016.036

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One case of choanal polyp originated from the apertura of sphenoidal sinus.

ZHAO Yuanyang, CHEN Xiumei, ZHANG Fen, WANG Beibei, WANG Chunyu, LI Zhiyun, ZHANG Qingquan

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(6):  120-120.  doi:10.6040/j.issn.1673-3770.0.2016.412

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