Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 56-59.doi: 10.6040/j.issn.1673-3770.0.2018.230

Previous Articles     Next Articles

Expression of immunological markers in middle ear effusion in children with secretory otitis media

NI Jing1, LEI Fei2, BAI Dan1, ZHOU Yun1, MA Jianmei1, HUANG Wei1, WANG Chunyang1   

  1. Department of Stomatology, the Second Affiliated Hospital of Xi′an Medical College, Xi′an 710038, Shaanxi, China
  • Online:2019-07-20 Published:2019-07-22

PDF (PC)

206

Abstract: Objective To evaluate the expression of immunological markers in middle ear effusion in children with secretory otitis media. Methods The research group included 30 patients with secretory otitis media, who were treated in our hospital from December 2016 to December 2017, while 30 healthy children were selected as the control group. The percentages of CD4+T and CD8+T cells and the CD4+/CD8+ ratio in the peripheral blood of the two groups were compared. The levels of IL-2, IL-4, and IL-6 in the middle ear effusion and plasma between the two groups were compared. The correlation of CD4+T and CD8+T cell values and IL-2, IL-4, and IL-6 in middle ear effusion was analyzed. Results The percentages of CD4+T and CD8+T cells in peripheral blood of the study group were significantly higher than that in the control group, and the CD4+/CD8+ ratio was significantly lower than that in the control group with a statistically significant difference(P<0.01). The levels of IL-2, IL-4, and IL-6 in the middle ear effusion of the group were significantly higher than that in the plasma, and the difference was statistically significant(P<0.01). The levels of IL-2, IL-4, and IL-6 in the study group were significantly higher than those in the control group, and the difference was statistically significant(P<0.01). Pearson linear correlation analysis showed that the levels of IL-2, IL-4, and IL-6 in the middle ear effusion of the group had a significantly positive correlation with CD4+T and CD8+T cell values in peripheral blood(P<0.01). Conclusion Secretory otitis media is closely related to the strong immune response and the phenomenon of significant rise in the CD4+T and CD8+T cell subgroup. Additionally, IL-2, IL-4, IL-6 showed a certain clinical significance in diagnosing and managing secretory otitis media in children.

Key words: Children, Secretory otitis media, Middle ear effusion, Immune, Infection

CLC Number: 

  • R764.2
[1] Feng CY, Zhang QC, Zhou GQ, et al. Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media[J]. Medicine(Baltimore), 2018, 97(13): e0211. doi:10.1097/MD.0000000000010211.
[2] Lameiras AR, Silva D, O Neill A, et al. Quality of life of children with otitis media and impact of insertion of transtympanic ventilation tubes in a portuguese population[J]. Acta Med Port, 2018, 31(1): 30-37. doi:10.20344/amp.9457.
[3] Ungkanont K, Boonyabut P, Komoltri C, et al. Surveillance of otitis media with effusion in thai children with cleft palate: cumulative incidence and outcome of the management[J]. Cleft Palate Craniofac J, 2018, 55(4): 590-595. doi:10.1177/1055665617730361.
[4] Akcan FA, Dündar Y, Akcan HB, et al. Clinical role of vitamin D in prognosis of otitis media with effusion[J]. Int J Pediatr Otorhinolaryngol, 2018, 105: 1-5. doi:10.1016/j.ijporl.2017.11.030.
[5] La Mantia I, Andaloro C. Effects of salso-bromo-iodine thermal water in children suffering from otitis media with effusion: a randomized controlled pilot study[J]. Clin Ter, 2018, 169(1): e10-e13. doi:10.7417/T.2018.2047.
[6] Blioskas S, Karkos P, Psillas G, et al. Factors affecting the outcome of adenoidectomy in children treated for chronic otitis media with effusion[J]. Auris Nasus Larynx, 2018, 45(5): 952-958. doi:10.1016/j.anl.2018.01.003.
[7] Simon F, Haggard M, Rosenfeld RM, et al. International consensus(ICON)on management of otitis media with effusion in children[J]. Eur Ann Otorhinolaryngol Head Neck Dis, 2018, 135(1S): S33-S39. doi:10.1016/j.anorl.2017.11.009.
[8] Akazawa K, Doi H, Ohta S, et al. Relationship between Eustachian tube dysfunction and otitis media with effusion in radiotherapy patients[J]. J Laryngol Otol, 2018, 132(2): 111-116. doi:10.1017/S0022215118000014.
[9] Zernotti ME, Pawankar R, Ansotegui I, et al. Otitis media with effusion and atopy: is there a causal relationship?[J]. World Allergy Organ J, 2017, 10(1): 37. doi:10.1186/s40413-017-0168-x.
[10] Gan RWC, Daniel M, Ridley M, et al. Quality of questionnaires for the assessment of otitis media with effusion in children[J]. Clin Otolaryngol, 2018, 43(2): 572-583. doi:10.1111/coa.13026.
[11] Zhang JB, Zhong Z, Xiao SF, et al. Tubomanometry value as an associated factor for medication outcomes in adult acute otitis media with effusion[J]. Eur Arch Otorhinolaryngol, 2018, 275(1): 53-57. doi:10.1007/s00405-017-4772-8.
[12] Bakshi SS. Neutrophil-lymphocyte and platelet-lymphocyte ratio for the effusion viscosity in otitis media[J]. J Craniofac Surg, 2018, 29(1): e98. doi:10.1097/SCS.0000000000004021.
[13] Chiappini E, Bortone B, Doria M, et al. What not to do in acute otitis media: the top five recommendations proposed by the Italian Society of Preventive and Social Pediatrics[J]. Expert Rev Anti Infect Ther, 2017, 15(10): 897-902. doi:10.1080/14787210.2017.1380518.
[14] Rahmati MB, Safdarian F, Shiroui B, et al. Montelukast versus inhaled mometasone for treatment of otitis media with effusion in children: A randomized controlled trial[J]. Electron Physician, 2017, 9(7): 4890-4894. doi:10.19082/4890.
[1] GE Peng, JIN Chunshun, YANG Jingpu, ZHAO Xue, CHAI Guijuan. Thyroid adenoma misdiagnose as primary tumors of trachea: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 179-182.
[2] Xi CHEN,Mingzhe QIAO. Progress of immune checkpoint inhibitors in the treatment of recurrent or metastatic head and neck squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 42-48.
[3] Chuangli HAO,Wenjing GU. Recognizing the etiology of chronic cough in children of different ages [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 20-24.
[4] Chuanhe LIU. The prevalence, diagnosis and management of asthma in children in China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 28-32.
[5] Qintai YANG. Paying attention to the 'lateral airway' allergic diseases in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 59-62.
[6] YANG Yaowei, LU Yingxia, GU Qinglong. Research on visit characteristics of children with acute laryngitis in Beijing between 2013 and 2017 and the correlation of the visit characteristics with meteorological factors and air pollutants [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 88-93.
[7] XU Ming, LUO Xinggu, TANG Hongbo, JIANG Qingshan. Clinical characteristics and prognostic factors for sudden idiopathic sensorineural hearing loss in children [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 41-44.
[8] LIU Bing, LI Bei, ZHANG Li, CHEN Min, ZHANG Jie. Clinical Analysis of Benign Paroxysmal Vertigo in preschool and school-age children [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 58-60.
[9] LIANG Zhengyan, DENG Yuqin, TAO Zezhang. Effect of maternal allergy and environmental exposure on immune maturation [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 96-104.
[10] LI Yanzhong, ZHANG Tai. Problems we face in children with obstructive sleep apnea hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 1-5.
[11] LIU Dabo. Evaluation of sleep structure disorder in children with obstructive sleep apnea hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 6-8.
[12] XU Zhifei, NI Xin. Post-surgery management in children with obstructive sleep apnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 9-13.
[13] WANG Yan, SHI Xiaoli. The relationship between allergic reaction and children obstructive sleep apnea hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 14-18.
[14] ZHONG Jianwen, LIU Dabo, LUO Xiangqian, HUANG Zhenyun, QIU Shuyao, CHENG Chao, YANG Liqiang, YI Xinhua, ZENG Jinhong. The application of wearable devices in the diagnosis of children obstructive sleep apnea [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 30-33.
[15] QIU Shuyao, LIU Dabo, ZHONG Jianwen, YANG Liqiang. Analysis of coblation complications in children with obstructive sleep apnea-hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 34-37.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] GONG Lei,SUN Jie,XUE Zi-chao,LI Jing-hua,XUE Wei-guo . DNA analysis of the cell cycle in sino-nasal neoplasm[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 193 -195 .
[3] CHEN Wen-wen . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(5): 472 -472 .
[4] LUAN Jiangang,LIANG Chuanyu,WEN Yanjun,LI Jiong . Construction of RNAi expressing plasmid vector of pSIRENshuttle for EGFR gene silencing[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 4 -8 .
[5] MA Jing, ZHONG Cui-ping . Surgical method for nasopharyngeal fibroangioma encroaching on fossa pterygopalatina: with a report of 5 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 30 -32 .
[6] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 223 -226 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 246 -247 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 250 -252 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 260 -262 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd