Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 99-104.doi: 10.6040/j.issn.1673-3770.0.2018.578

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Relationship between carotid elasticity and oxidative stress in patients with obstructive sleep apnea syndrome

SONG Fan, HUANG Weijun, XU Huajun, GUAN Jian, YI Hongliang   

  1. Department of Otorhinolaryngology Head and Heck Surgery, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
  • Online:2019-07-20 Published:2019-07-22

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Abstract: Objective This study aimed to investigate the relationship between carotid elasticity and oxidative stress in patients with obstructive sleep apnea syndrome(OSAS). Methods Patients with suspected OSAS, and healthy volunteers were recruited. According to the apnea-hypopnea index, 36 patients each were enrolled in the OSAS group and control group. The sex, age, and body mass index(BMI)of the two groups were matched. Serum malondialdehyde(MDA)and glutathione(GSH)levels were estimated using enzyme-linked immunosorbent assay. Quality intima-media thickness(QIMT)and quality arterial stiffness(QAS)techniques were used to detect the bilateral carotid intima-media thickness(IMT), distensibility coefficient, compliance coefficient, pulse wave velocity, and stiffness coefficients α and β. The correlation factors between oxidative stress and arterial elasticity were analyzed by correlation analysis. Multiple linear regression analysis was used to analyze the independent risk factors of IMT. Results There was no difference in sex, age, BMI, high-density lipoprotein, urinary microalbumin, cystatin C, and diastolic blood pressure between the OSAS group and the control group (P>0.05). Triglyceride, total cholesterol, low-density lipoprotein, high-sensitivity C-reactive protein, insulin resistance, blood glucose, systolic blood pressure, and sleep parameters of the two groups were significantly different (P<0.05). Serum MDA and GSH levels were higher in the OSAS group than in the control group (P<0.05). There was no significant difference in carotid IMT and arterial elasticity between the groups. Carotid IMT and arterial elasticity were not correlated with MDA and GSH levels. Linear regression showed that age and low-density lipoprotein were independent risk factors for carotid IMT. Conclusion The increased oxidative stress response in patients with OSAS is insufficient to affect carotid elasticity. Age and low-density lipoprotein are independent risk factors for carotid IMT.

Key words: Obstructive sleep apnea syndrome, Carotid intima-media thickness, Arterial elasticity, Oxidative stress

CLC Number: 

  • R766.43
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