Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (6): 78-80.doi: 10.6040/j.issn.1673-3770.0.2019.199

Previous Articles    

Phototriggered imine-cross-linked hydrogels with mitomycin C for prevention of vocal cord adhesion after cordectomy: a canine model

SONG Zhiyuan1, YI Hongliang1, WANG Yang2, YANG Yunlong2、3   

  1. Institute of Extremity Revival, Sixth Peoples Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China;
    3. China Key Laboratory of Institute of Fine Chemical Engineering, University of Science and Technology, Shanghai 200237, China
  • Published:2019-12-23

Abstract: Objective To evaluate the feasibility of a canine model of vocal cord adhesion(VCA)and to determine the effectiveness of nitro-benzyl alcohol-modified hyaluronic acid(HA-NB)with mitomycin C(MMC)for the prevention of postoperative VCA using a canine model. Methods Sixteen male beagle dogs were divided into four groups(4 dogs in each group)and treated with saline(control group), HA-NB, MMC, or HN-MMC after VCA was induced by radiofrequency coblation using a suspension laryngoscope. At 8 weeks after surgery, the extent of VCA was determined to evaluate the preventive effects of HA-NB, MMC, and HN-MMC. All larynges were harvested and examined histologically. Results VCA induction was successful in all groups. VCA ratio was evaluated at 8 weeks after the initial surgery. The mean VCA ratio in both the HA-NB and MMC groups was not significantly different to that of the control group, but it was lower in the HN-MMC group than that in the control group. The estimated marginal means of HA-NB*MMC were lowest in the HN-MMC group and showed a significant synergistic interaction between HA-NB and MMC. The scar elevation index(SEI)in the HN-MMC group was significantly lower than that in any other groups. Conclusion The combination of HA-NB gel and MMC was more effective for the prevention of postoperative VCA formation than a single application of HA-based gel or MMC.

Key words: Mitomcin C, Hyaluronic acid, Vocal folds adhesion

CLC Number: 

  • R767
[1] Hoffmann C, Cornu N, Hans S, et al. Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy[J]. Laryngoscope, 2016, 126(8): 1817-1822. doi:10.1002/lary.25757.
[2] Kwon SK, Kim DW, Ryu YJ, et al. Novel experimental rabbit model of anterior glottic web formation[J]. Acta Otolaryngol, 2015, 135(8): 840-845. doi:10.3109/00016489.2015.1028594.
[3] Chung JH, Cosenza MJ, Rahbar R, et al. Mitomycin C for the prevention of adhesion formation after endoscopic sinus surgery: A randomized, controlled study[J]. Otolaryngol Head Neck Surg, 2002, 126(5): 468-474. doi:10.1067/mhn.2002.124705.
[4] Su CH, Yao CJ, Lu SH, et al. Study on the optimal concentration of topical mitomycin-C in preventing postlaminectomy epidural adhesion[J]. Eur J Pharmacol, 2010, 640(1/2/3): 63-67. doi:10.1016/j.ejphar.2010.04.039.
[5] Fang R, Sun JW, Wan GL, et al. Comparison between mitomycin C and chitosan for prevention of anterior glottic Steno after CO2 laser cordectomy in dogs[J]. Laryngoscope, 2007, 117(11): 2057-2062. doi:10.1097/MLG.0b013e3181256511.
[6] Yang YL, Zhang JY, Liu ZZ, et al. Tissue-integratable and biocompatible photogelation by the imine crosslinking reaction[J]. Adv Mater Weinheim, 2016, 28(14): 2724-2730. doi:10.1002/adma.201505336.
[7] Zhang JY, Yang YL, Chen YF, et al. An in situ phototriggered-imine-crosslink composite hydrogel for bone defect repair[J]. J Mater Chem B, 2016, 4(5): 973-981. doi:10.1039/c5tb02377g.
[8] Cheng LY, Sun XM, Hu CM, et al. In vivo early intervention and the therapeutic effects of 20(s)-ginsenoside rg3 on hypertrophic scar formation[J]. PLoS One, 2014, 9(12): e113640. doi:10.1371/journal.pone.0113640.
[9] 台勇, 娄卫华, 王卫, 等. T形硅胶膜在喉癌双侧声带切除术后的应用[J]. 河南医学研究, 2013, 22(1): 57-58. doi:10.3969/j.issn.1004-437X2013.01.024.
[10] 漫一凡, 张超, 周延辉, 等. V 形喉硅胶膜在声门型喉癌中的应用研究[J]. 河南科技大学学报(医学版), 2015, 33(2): 100-104. doi:10.3969/j.issn.1672-688X.2015.02.007. MAN Yifan, ZHANG Chao, ZHOU Yanhui, et al. Application study on V-shaped laryngeal silica membrane in glottic laryngeal cancer[J]. Journal of Henan University of Science & Technology(Medical Science), 2015, 33(2): 100-104. doi:10.3969/j.issn.1672-688X.2015.02.007.
[11] Ünal M. The successful management of congenital laryngeal web with endoscopic lysis and topical mitomycin-C[J]. Int J Pediatr Otorhinolaryngol, 2004, 68(2): 231-235. doi:10.1016/j.ijporl.2003.09.018.
[12] Liu XL, Yang YL, Niu X, et al. An in situ photocrosslinkable platelet rich plasma-Complexed hydrogel glue with growth factor controlled release ability to promote cartilage defect repair[J]. Acta Biomater, 2017, 62: 179-187. doi:10.1016/j.actbio.2017.05.023.
[13] Tabaee A, Brown SM, Anand VK. Mitomycin C and endoscopic sinus surgery: where are we?[J]. Curr Opin Otolaryngol Head Neck Surg, 2007, 15(1): 40-43. doi:10.1097/MOO.0b013e328011bcae.
[14] Homma A, Sato H, Tamura T, et al. Synthesis and optimization of hyaluronic acid-methotrexate conjugates to maximize benefit in the treatment of osteoarthritis[J]. Bioorg Med Chem, 2010, 18(3): 1062-1075. doi:10.1016/j.bmc.2009.12.053.
[1] Lu LUO,En ZHOU,Si OUYANG,Yi CHEN,Xuping XIAO,Jihua WANG. Expression of the microRNA let-7a in the serum of 42 patients with laryngeal cancer and its significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 96-100.
[2] Yangfan LIU,Jian JIA,Baoluo WAN. A retrospective study on clinic manifestation and pathological of the larynx leukoplakia in 76 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 162-165.
[3] Meijun ZHENG,Hui YANG,Juanjuan HU. Advances in phonomicrosurgery for glottic webs [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 144-147.
[4] ZHAO Yan, CHENG Sihua, TONG Qiaozhen. Effects of intensive self-care on voice recovery and psychological emotions in patients undergoing laryngoscope-assisted vocal cord polypectomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 175-178.
[5] Ruofei HUANG,Lixiao CHEN,Xinwei CHEN,Ziwei YU,Bin JIN,Jiangcai ZHU,Pin DONG. Recurrent laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 36-39.
[6] Xiaobo CUI. Significance of induction chemotherapy in late treatment of locally advanced hypo-pharyngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 10-17.
[7] Xinjie ZHU,Qingzhao ZHANG,Xi CHEN. Intramuscular lipoma of the larynx:a case report [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 152-153.
[8] Jiejie XU. Physiological characteristics of voice and care of vocal health in the elderly [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 14-18.
[9] Yongyao LANG,Yun YANG,Qing LIU,Lindi XU,Ziping LIN. Analysis of influencing factors and observation of therapeutic effects in patients with laryngopharyngeal reflux disease [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 119-123.
[10] Lixian JU,Jingcheng LI,Keyu XIA,Weida DONG. Vocal polyps treated with nasal endoscopy and angled-laryngeal forceps: report of 23 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 116-118.
[11] Yujie SHEN,Liqing ZHANG,Han ZHOU,Qing ZHAO,Jian FENG,Shenghua SONG,Weida DONG. Clinical analysis of 34 cases of cervical lipoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 111-115.
[12] Huijun CHEN,Shenghua SONG,Han ZHOU,Weida DONG,Mingzhe QIAO,Xi CHEN,Jin XU,Ziping LIN,Guangqian XING. Preoperative platelet-lymphocyte ratio is an independent prognostic factor for laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 106-110.
[13] YANG Yaowei, LU Yingxia, GU Qinglong. Research on visit characteristics of children with acute laryngitis in Beijing between 2013 and 2017 and the correlation of the visit characteristics with meteorological factors and air pollutants [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 88-93.
[14] Wenbin LEI,Qihong LIU. Progress in the treatment of recurrent respiratory papillomatosis using a CO2 laser [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 8-12.
[15] Ming LIU. Treatment of epiglottic carcinoma by transoral laser microsurgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 4-7.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!