Abstract: Objective To investigate the clinical characteristics, diagnosis, treatment, and prognosis of primary localized tonsil amyloidosis, to enable its early diagnosis. Methods A patient with primary localized tonsil amyloidosis was retrospectively reviewed, along with previous cases of primary localized tonsil amyloidosis found in the literature. Results The clinical manifestations of primary localized tonsil amyloidosis lack specificity, and its early manifestations are often atypical. Besides, the disease often rapidly progresses. The clinical manifestations are mainly a pharyngeal foreign body sensation caused by the asymmetric growth or rapid enlargement of the bilateral tonsil. Other non-specific manifestations include tonsil growth, an ulcer, dry pharynx, pharynx itch, pharynx pain, and dysphagia. For patients with painless hypertrophy of the tonsil and no inflammatory symptoms, a pathological biopsy should be performed if bilateral tonsil asymmetry is apparent, there is a surface ulcer, the texture is hard, or the history is short. Conclusion The clinical and imaging manifestations of primary localized tonsil amyloidosis are non-specific. Therefore, it is imperative to carefully consider the patient's medical history, systemic examination findings, and pathological biopsy findings to diagnose primary localized tonsil amyloidosis at an early stage.

Key words: Primary limitations, Amyloidosis, Tonsils, Clinical manifestations, Pathological biopsy