Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 163-168.doi: 10.6040/j.issn.1673-3770.0.2021.273

Previous Articles    

Effects of ischemic stroke and other neurodegenerative diseases on RNFL thickness

LI Yingying1,2, FENG Jie1,LI Wei2, DING Tianjiao2   

  1. 1. School of clinical medicine, Jining Medical University, Jining 272067, Shandong, China;
    2. Department of Ophthalmology, Jining NO. 1 People's Hospital, Jining 272011, Shandong, China
  • Published:2022-04-15

Abstract: The retina and the brain have similar embryonic origin and anatomical and physiological characteristics. The retinal nerve fiber layer(RNFL)is mainly composed of axons of retinal ganglion cells, which can be observed and quantified in vivo by optical coherence tomography(OCT). RNFL thinning is a part of normal aging, it can also be seen in neurodegenerative diseases such as ischemic stroke, Alzheimer's disease, Parkinson's disease,multiple sclerosis. With the rapid development of ophthalmic imaging techniques such as OCT, RNFL thickness is widely used in clinic,which provides clinical data of retinal ganglion cell loss in patients with ischemic stroke and other neurodegenerative diseases. Clinicians can intervene as soon as possible to delay the progress of retinal nerve fiber layer defect and further improve the quality of life of patients.

Key words: Ischemic stroke, Neurodegenerative diseases, Optical coherence tomography, Retinal nerve fiber layer

CLC Number: 

  • R774
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