眼弓形体病的发病机制及防治研究进展

doi:10.6040/j.issn.1673-3770.0.2022.076

Abstract

Abstract: Ocular toxoplasmosis is a unilateral necrotizing retinochoroiditis caused by intraocular infection with Toxoplasma gondii. When people are infected with T.gondii, tachyzoites can cross the blood-retinal barrier and infect most nucleated cells to directly cause tissue damage. At the same time, they can also cause a series of excessive cellular immune responses to further aggravate tissue damage and cause visual impairment. Finally, tachyzoites can create an equilibrium between parasite invasion and host resistance, thus forming tissue cysts in the host. Aside from the traditional drug treatment of pyrimethamine and sulfadiazine in clinical practice, new combined treatment programs and anti-T.gondii compounds have also been studied and applied to achieve precise treatment and reduce the toxic and side effects of systemic drugs. This article focuses on reviewing the pathogenesis and control of ocular toxoplasmosis, together with the current clinical predicaments, so as to provide a theoretical basis for the diagnosis and treatment of this disease in the future.

Key words: Ocular toxoplasmosis, Clinical features, Cellular immunity, Treatment strategies, Drug target

CLC Number:

R774.1

ZHANG YuOverview,QU YiGuidance. Research progress on the pathogenesis and control of ocular toxoplasmosis[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 70-76.

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