人乳头瘤病毒相关口咽鳞状细胞癌发生机制的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.172

Abstract

Abstract: This article briefly describes the biological characteristics of human papillomavirus(HPV), the mechanism of persistent infection of human papillomavirus in the oropharyngeal mucosa, and introduces the biological process of viral proteins in the process of causing oropharyngeal squamous cell carcinoma(OPSCC). By reviewing relevant clinical studies, summarizing the relevant literature, we concluded that in HPV-associated OPSCC, the unique anatomy of the oropharynx makes it difficult to clear the HPV infected and maintain a persistent infection state. The persistently infection of HPV affects the occurrence and development of tumors through the expression of viral proteins and interacts with the tumor microenvironment. We propose some mechanism pathway with viral protein in host cells, especially viral proteins E6, E7, which not only promote the occurrence of OPSCC, but also increase the sensitivity of chemotherapy drugs against tumors. we believe that this dual role of viral proteins provides a new direction for us to further understand HPV-related OPSCC and propose better treatment options.

Key words: Human papillomavirus, Oropharyngeal squamous cell carcinoma, Tonsil crypt, Viral protein, Tumor microenvironment

CLC Number:

R739.63

LI Yanan, LIANG Hui. Study progress on the mechanism of human papillomavirus-related oropharyngeal squamous cell carcinoma[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 104-110.

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Study progress on the mechanism of human papillomavirus-related oropharyngeal squamous cell carcinoma

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