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Meta-analysis of clinical intradermal acupuncture efficacy for treatment of allergic rhinitis
- ZHAI Rui, LI Yuan, YU Jinglong, CHEN Xi, ZHENG Youyou, LIU Zhaolan, WANG Junhong
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Journal of Otolaryngology and Ophthalmology of Shandong University. 2023, 37(3):
35-45.
doi:10.6040/j.issn.1673-3770.0.2022.364
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Objective To systematically evaluate the clinical efficacy and safety of intradermal acupuncture in the treatment of allergic rhinitis using Meta-analysis. Methods PubMed, The Cochrane Library, Web of Science, SinoMed, VIP, CNKI, and Wanfang databases were searched for randomized controlled trials which used intradermal acupuncture to treat allergic rhinitis from database inception to October 1, 2022. Two researchers conducted independent screening, data extraction, bias risk assessment, and meta-analysis of the literature. Results This study included 29 clinical trials and 2342 patients. Compared with the positive control group, the intradermal acupuncture combined therapy group showed improvements in clinical total effective rate [RR=1.24, 95%CI(1.16, 1.33), P<0.001], quantitative scores of symptoms and signs [MD=-0.67, 95%CI(-1.12, -0.22), P=0.003], visual analogue score of nasal symptoms [MD=-0.62, 95%CI(-0.97, -0.28), P<0.001], number of recurrences [RR=0.58, 95%CI(0.41, 0.82), P=0.002], nasal resistance [MD=-0.13, 95%CI(-0.21, -0.05), P=0.001], and quality of life score for nasal conjunctivitis[MD=-4.17, 95%CI(-6.06, -2.29), P<0.001]. Compared with antihistamines, there was no significant difference in clinical total effective rate[RR=1.01, 95%CI(0.92, 1.11), P=0.78] and quality of life score for nasal conjunctivitis[MD=0.43, 95%CI(-1.78, 2.65), P=0.70] after treatment. No serious adverse reactions occurred after intradermal acupuncture treatment. Conclusion Using intradermal acupuncture to treat allergic rhinitis shows good curative effects and safety, and can reduce recurrence rates and nasal resistance, as well as improve quality of life. Due to the limits of our experimental design and issues related to the quantity and quality of original literature, the results of our meta-analysis still need to be further verified. In the future, relevant research should utilize other methodologies and strict experimental designs to provide more powerful, high-quality evidence-based data for the development of clinical diagnosis and treatment guidelines.