Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (4): 160-165.doi: 10.6040/j.issn.1673-3770.0.2022.179

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Review of pyroptosis molecular mechanism and applications in head and neck squamous cell carcinoma

YANG Yingling1,2, GOU Haocheng2, FENG Jun2   

  1. 1. North Sichuan Medical College, Nanchong 637000, Sichuan, China2. Department of Otorhinolaryngology, The Second Clinical College of North Sichuan Medical College/Nanchong Central Hospital, Nanchong 637000, Sichuan, China
  • Published:2023-07-27

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Abstract: Poor survival rates for cancer patients have led to further research on treatments to fight the disease. Programmed cell death(PCD)plays an important role not only in embryonic development, but also in occurrence and development of cancers. Pyroptosis is a type of PCD which has been receiving increasing attention for its dual role in tumors. This paper describes the molecular mechanisms of pyroptosis in terms of anti-cancer properties and aims to gain insight into its potential for cancer resistance. We also introduce related research on head and neck squamous cell carcinoma.

Key words: Pyroptosis, Head and neck squamous cell carcinoma, Gasdermin, Caspase

CLC Number: 

  • R739.6
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