Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (5): 95-99.doi: 10.6040/j.issn.1673-3770.0.2023.258

• Original Article • Previous Articles    

Corneal perforation caused by microsporidia infection: a case report and literature review

WANG Ling1, LI Ming1,2, YING Fangwei1, WANG Yu1, WEN Wen1, YAO Xiaoming1   

  1. 1. Shenzhen Eye Institute, Shenzhen Eye Hospital, Shenzhen 518040, Guangdong, China2. Corneal Disease Department, Shenzhen Eye Hospital, Shenzhen 518040, Guangdong, China
  • Published:2024-09-25

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Abstract: Objective To investigate the diagnosis, treatment, clinical features, diagnostic principles, and research progress of corneal perforations caused by Microsporidia infection. Methods We retrospectively analyzed the clinical data of a patient with corneal perforation caused by Microsporidia infection and reviewed relevant literature. Results Microsporidial infection of corneal ulcer perforation is a rare infectious ocular disease. The transmission route is unclear but could be related to unclean hand hygiene. The diagnosis can be confirmed through corneal tissue examination, fluorescent whitening agent staining, and metagenomic detection. Early metagenomic detection during the disease course is crucial for the early identification of pathogen types and timely medication prescriptions. Conclusion In recent years, increased cases of Microsporidium keratoconjunctivitis have occurred in healthy individuals. Clinicians should consider Microsporidium keratoconjunctivitis in diagnosing conjunctivitis-related atypical punctate epithelial keratitis to avoid corneal perforation, which seriously endangers vision.

Key words: Corneal ulcer, Microsporidium, Vittaforma corneae, Cornea transplantation, Metagenomics Next-Generation Sequencing

CLC Number: 

  • R770.4
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