Abstract: Objective To review the clinical characteristics and individualized surgical management options for giant pleomorphic adenoma of the palate. Methods A retrospective analysis of the clinical data of a patient with a giant pleomorphic adenoma of the palate was performed and the relevant literature was reviewed and synthesized. Results Pleomorphic adenoma of the palate is a morphologically complex epithelial tumor that frequently manifests in the posterior aspect of the hard palate, at the junction with the soft palate. It typically presents clinically as an asymptomatic, slow-growing, isolated, smooth mass with partial or intact periosteum, which can result in compressive bone resorption. The tumor may cause dysphagia, dyspnea, difficulty chewing and rhinorrhea, depending on its location. The potential risk of malignancy associated with the growth process of pleomorphic adenoma necessitates a primarily surgical approach to treatment. Conclusion For giant pleomorphic adenomas originating from the hard palate, treatment should be individualized to assess and develop a surgical plan. Limited tumors can be treated with the traditional transhard-palatal approach, whereas larger tumors require the endoscopic-assisted translabiogingival sulcus approach or the endoscopic-assisted transoronasal combined approach.

Key words: Palatal mass, Hard palate, Pleomorphic adenoma, Endoscopy