Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 63-66.doi: 10.6040/j.issn.1673-3770.1.2018.034

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Analysis of prevalence and related risk factors of bee venom in bee research population

CUI Le1,2, GUAN Kai1,2, LI Lisha1,2, LI Junda1,2, WANG Zixi1,2, XU Yingyang1,2, WANG Lianglu1,2, YIN Jia1,2   

  1. Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing 100730, China
  • Online:2019-01-20 Published:2019-01-28

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Abstract: Objective Allergic reactions to bee venom are one of the common causes of severe allergic reactions. There are few studies on bee venom allergy in China; particularly, there is a lack of data on people at high risk of bee venom allergy. This study investigated the prevalence and clinical characteristics of bee venom allergies in the bee study population and analyzed the risk factors. Methods In September 2018, a cross-sectional survey was conducted among people who had been engaged in bee-related research at the Bee Research Institute of the Chinese Academy of Agricultural Sciences and the Department of Entomology of China Agricultural University. Results A total of 100 people were included in the study: median age 28 years(range: 19-56 years); females accounted for 69.0%. Among them, 34 cases(34.0%)reported having had allergic reactions to bee venom at work, 6 cases(6%)had large local reactions, and 28 cases(28%)had systemic reaction reactions. Among the 28 systemic reaction responders, there were 7, 7, 4, and 10 cases of systemic reactions in grades 1-4, respectively. The systemic reaction of grade 4 was the commonest(35.7%). Fifty percent of systemic reaction responders experienced large local reactions after initial bee sting. Logistic regression showed that the level of exposure, that is, the frequency of bee stings was a risk factor for bee venom allergy. Compared with the respondents who were not been stung in the past year, the OR(95% CI)of bee venom allergy of 1-3 and ≥4 bee stings in the past year were 6.362 ［95% confidence interval(CI), 2.014-20.092］ and 41.437(95% CI, 6.842-250.964). There was no statistically significant correlation between respondents' personal or family history of allergies(e.g. allergic rhinitis), family history of bee venom allergy and bee venom allergy(odds ratios=0.683(95% CI, 0.197-2.366), 0.600(95% CI, 0.131-2.749)and 2.582(95% CI, 0.201-33.099), respectively). Conclusion The situation of bee venom allergy in high-risk population cannot be ignored. For high-risk groups, it is necessary to pay close attention to protection and provide emergency medicine and equipment.

Key words: Bee venom, Allergic reaction, Prevalence, Cross-sectional survey, Risk factors

CLC Number: 

  • R392.8
[1] Casale TB, Burks AW. Clinical practice. Hymenoptera-sting hypersensitivity[J]. N Engl J Med, 2014, 370(15):1432-1439. doi:10.1056/NEJMcp1302681.
[2] Bilo BM, Rueff F, Mosbech H, et al. Diagnosis of Hymenoptera venom allergy[J]. Allergy, 2005, 133960(11):1339-1349. doi:10.1111/j.1398-9995.2005.00963.x.-1349.
[3] Ring J,Messmer K. Incidence and severity of anaphylactoid reactions to colloid volume substitutes [J]. Lancet(London, England), 1977, 1(8009):466-469. doi: 10.1016/S0140-6736(77)91953-5.
[4] Incorvaia C, Mauro M, Pravettoni V, et al. Hypersensitivity to Hymenoptera venom: advances in diagnosis and implications for treatment[J]. Recent Pat Inflamm Allergy Drug Discov, 2011, 5(2):128-135.
[5] Mueller HL. Diagnosis and treatment of insect sensitivity[J]. J Asthma Res, 1966, 3(4):331-333.
[6] Bilò MB. Anaphylaxis caused by Hymenoptera stings: from epidemiology to treatment[J]. Allergy, 2011, 66(Suppl 95):35-37. doi:10.1111/j.1398-9995.2011.02630.x.
[7] Fernandez J, Blanca M, Soriano V, et al. Epidemiological study of the prevalence of allergic reactions to Hymenoptera in a rural population in the Mediterranean area[J]. Clin Exp Allergy, 1999, 29(8):1069-1074.
[8] Romero-Gómez, M., G.E. Suárez and F.M. Castro, Hymenoptera stings in conscripts[J]. Allergy, 1997, 52(6):680-681.
[9] Hayashih Y, Hirata H, Watanabe M, et al. Epidemiologic investigation of hornet and paper wasp stings in forest workers and electrical facility field workers in japan[J]. Allergol Int, 2014, 63(1):21-26. doi:10.2332/allergolint.13-OA-0556.
[10] Kochuyt AM, Van Hoeyveld E, Stevens EA. Occupational allergy to bumble bee venom[J]. Clin Exp Allergy, 1993, 23(3):190-195.
[11] Bonadonna P, Schiappoli M, A DM, et al. Is hymenoptera venom allergy an occupational disease?[J]. Occupational and Environmental Medicine, 2008, 65(3):217-218. doi:10.1136/oem.2007.036400.
[12] Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions[J]. Clin Exp Allergy, 2000, 30(8):1144-1150.
[13] 关凯, 李丽莎, 王瑞琦, 等. 蜜蜂蜂毒致严重过敏反应临床特征[J]. 中华临床免疫和变态反应杂志, 2016, 10(3):197-201. doi:10.3969/j.issn.1673-8705.2016.03.003. GUAN Kai, LI Lisha, WANG Ruiqi, et al. Clinical characteristics of anaphylaxis induced by honeybee venom[J]. Chinese Journal of Allergy & Clinical Immunology, 2016, 10(3):197-201. doi:10.3969/j.issn.1673-8705.2016.03.003.
[14] 崔乐, 王子熹, 关凯, 等. 蜂疗致蜂毒过敏的临床特征及影响因素[J]. 中华临床免疫和变态反应杂志, 2018, 12(3):277-282. doi:10.3969/j.issn.1673-8705.2018.03.004. CUI Le, WANG Zixi, GUAN Kai, et al. Clinical manifestations and risk factors of honeybee venom allergy induced by apitherapy[J]. Chinese Journal of Allergy & Clinical Immunology, 2018, 12(3):277-282. doi:10.3969/j.issn.1673-8705.2018.03.004.
[15] Birnbaum J, Vervloet D, Charpin D. Atopy and systemic reactions to hymenoptera stings[J]. Allergy Proc, 1994,15(2):49-52.
[16] Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003[J]. J Allergy Clin Immunol, 2004, 113(5):832-836. doi:10.1016/j.jaci.2003.12.591.
[17] Siracusa A, Folletti I, Gerth van Wijk R, et al. Occupational anaphylaxis-an EAACI task force consensus statement[J]. Allergy, 2015,70(2):141-152. doi: 10.1111/all.12541.
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