Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (3): 31-36.doi: 10.6040/j.issn.1673-3770.1.2020.108

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Narrow band imaging might contribute to the diagnosis of laryngopharyngeal reflux

WU Dipanpan1, CUI Xinhua2, GUO Ying2, GENG Bo2, GAO Fangfang2, LIANG Hui2   

  1. 1. Liaocheng People's Hospital, Liaocheng 252000, Shandong, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China
  • Published:2021-05-14

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Abstract: Objective To explore the possible role of narrow band imaging(NBI)in the diagnosis of laryngopharyngeal reflux(LPR). Methods According to the Chinese domestic expert consensus on the diagnosis and treatment of laryngopharyngeal reflux(LPR), we recruited 39 LPR patients who visited our outpatient department. All patients were assessed using the reflux symptom index(RSI)and questionnaires on the reflux finding score(RFS)and NBI endoscopy before and after treatment. At the same time, we selected 19 symptom-negative controls and completed the above examinations. Results Initially, we recruited 39 LPR-positive patients, although two were lost. Compared with the consensus standard, the sensitivity of NBI was 94.6%, its specificity was 78.9%,(Kappa=0.755, P<0.001). Before treatment: According to NBI, the positivity rate was 94.6%. In the control group, the positivity rate was 21.1%. The positivity rates based on RSI and RFS were 24.3% and 94.6%, respectively. The results showed that NBI was as effective as RFS(P=0.003), and the consistency between NBI and RSI was poor(P=0.040). The positivity rate of the study group was significantly different from that of the control group(P<0.001). After treatment, only 21 patients with LPR agreed to undergo post-treatment. The positivity rate of NBI was 71.4%, while that of RSI was 9.5%, indicating poor consistency(P<0.001). The positivity rate of RFS was 61.9%, which was relatively better than that of NBI(Kappa=0.576, P=0.007), showing statistical significance. Compared with the pre-study, the positive rate dropped from 90.5% to 71.4%, although the difference was not statistically significant(P=0.119). Conclusion NBI is valuable for LPR diagnosis.

Key words: Laryngopharyngeal reflux, Narrowband imaging, Diagnosis, Microvessel images, Reflux symptom Index, Reflux finding score

CLC Number: 

  • R766.5
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