Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (4): 114-119.doi: 10.6040/j.issn.1673-3770.1.2021.152

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Research advances in neuroendocrine carcinoma of the larynx

MAO ZefanOverview,CHEN Xi, CHENG LeiGuidance   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2022-07-11

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Abstract: Neuroendocrine carcinoma of the larynx is a rare malignant tumor of the larynx that originates from epithelial neuroendocrine cells. Based on the degree of differentiation and cell type, it can be divided into four histological subtypes: typical carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma, and large cell neuroendocrine carcinoma. Despite the substantial differences across these subtypes, an accurate description of their differences has been impeded by the overly low incidence. A number of studies reported are frequently contradictory due to too few cases reported or the inability to collect a sufficient sample size, making it difficult to reach a consensus. This paper reviews the recent literature reports on the clinical behavior, characteristics, diagnosis, treatment, and prognosis of neuroendocrine carcinoma of the larynx, to provide an evidence for clinicians to broaden their understanding and optimize the diagnosis and treatment protocol for this disease.

Key words: Laryngeal neoplasm, Neuroendocrine carcinoma of the larynx, Epithelial neuroendocrine cells, Small cell neuroendocrine carcinoma, Large cell neuroendocrine carcinoma

CLC Number: 

  • R739.65
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