Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 76-80.doi: 10.6040/j.issn.1673-3770.0.2018.423

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Clinical significance and correlation between MIF and GSK-3β expression in laryngeal squamous cell carcinoma

ZOU Liangyu1, LI Lianhe2, YUE Wenhui2, HAN Zhipeng3, ZHANG Zihui3   

  1. Department of Otolaryngology, Chaoyang Central Hospital, Chaoyang 122000, Liaoning, China;
    3. Department of Pathology, Chaoyang Central Hospital, Chaoyang 122000, Liaoning, China
  • Published:2019-03-28

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Abstract: Objective To investigate the clinical significance and correlation of macrophage migration inhibitory factor(MIF)and glycogen synthase kinase-3(GSK-3β)expression in laryngeal squamous cell carcinoma. Methods The expression of MIF and GSK-3β in cancerous tissues and corresponding non-cancerous tissues of 30 patients with laryngeal squamous cell carcinoma were examined by immunohistochemistry and compared with mucosal tissues from 10 patients without laryngeal squamous cell carcinoma. The relationship between MIF and GSK-3β expression in laryngeal tissue and the clinicopathological factors of patients was analyzed. The correlation between MIF and GSK-3β expression in laryngeal squamous cell carcinoma was also investigated. Results The expression rates of MIF in laryngeal carcinoma tissues, adjacent tissues and non-cancerous laryngeal mucosa were 73.33%, 40.00%, 20.00%, respectively. The expression rates of GSK-3β in the three tissue types mentioned above were 70.00%, 13.33%, and 20.00%, respectively. MIF and GSK-3β expression were correlated with tumor differentiation, TNM stage and lymph node metastasis, but not associated with age, gender, smoking history or drinking history (P>0.05). MIF and GSK-3β expression were also correlated with each other (r=0.592, P=0.003). Conclusion Increased MIF and GSK-3β expression can occur in laryngeal squamous cell carcinoma and in laryngeal squamous cell carcinoma disease progression. MIF and GSK-3β may be used as potential biomarkers for laryngeal cancer and as indicators of progression and prognosis during observation and monitoring of laryngeal cancer patients.

Key words: Laryngeal neoplasms, Macrophage migration inhibitory factor, Glycogen synthase kinase-3, Biomarkers

CLC Number: 

  • R767
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