Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (1): 68-73.doi: 10.6040/j.issn.1673-3770.0.2024.488

• Original Article • Previous Articles     Next Articles

The application of AI screening system based on OCT/OCTA in the evaluation of the effect of anti VEGF treatment in patients with diabetes macular edema

ZHU Mingqiong, LI Zheng, LIU Ru, TIAN Tao, PENG Jingli, LYU Qianyi, TAN Huaxia   

  1. Department of Ophthalmology, Chenzhou No.1 People's Hospital, Chenzhou 423000, Hunan, China
  • Online:2026-01-20 Published:2026-02-13

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Abstract: Objective To analyze the application effect of an artificial intelligence(AI)screening system based on optical coherence tomography(OCT)/optical coherence tomography angiography(OCTA)in the evaluation of the efficacy of anti-vascular endothelial growth factor(VEGF)in the treatment of patients with diabetic macular edema. Methods 120 patients with diabetic macular edema diagnosed and treated from January 1, 2022 to January 31, 2024 were selected. According to the diabetic macular edema, they were divided into 42 cases of diffuse edema, 40 cases of cystic edema, and 38 cases of mixed macular edema. All patients underwent anti-VEGF treatment for 3 months. The AI screening system based on OCT/OCTA was used to measure and compare the area of the fovea avascular area, the thickness of the macular central retinal center, the thickness of the retinal ganglion cell layer, the thickness of the retinal nerve fiber layer, and the blood flow density of the retinal blood flow(deep capillary plexus in the retinal layer, and the superficial capillary plexus in the retinal layer)before and after treatment. Results The area of the fovea avascular area, the thickness of the macular central retinal, the thickness of the retinal ganglion cell layer, the thickness of the retinal nerve fiber layer, and the blood flow density of the retinal patients after treatment were better than before treatment(P all <0.05). The area of the fovea avascular area, the thickness of the macular central retinal, the thickness of the retinal ganglion cell layer, the thickness of the retinal nerve fiber layer, and the blood flow density of the retinal blood flow density of the retinal patients after treatment were better than those of the mixed macular edema(P all <0.05). Conclusion The AI screening system based on OCT/OCTA can more accurately evaluate the anti-VEGF treatment effect of patients with different types of diabetic macular edema, providing assistance in guiding future clinical treatment work and is worthy of promotion and application.

Key words: Diabetic macular edema, Optical coherence tomography, Optical coherence tomography angiography, Artificial intelligence, Anti-vascular endothelial growth factor, Classification, Treatment effect

CLC Number: 

  • R774.5
[1] 方立建, 魏文斌. 康柏西普玻璃体腔内注射联合阈值下微脉冲激光治疗糖尿病黄斑水肿的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2020, 10(2): 90-96. doi:10.3877/cma.j.issn.2095-2007.2020.02.005 FANG Lijian, WEI Wenbin. The effect of Conbercept combined with subthreshold micropulse laser photocoaguIation on diabetic macular edema[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020,10(2): 90-96. doi:10.3877/cma.j.issn.2095-2007.2020.02.005
[2] Lim SY, Wong WM, Seah I, et al. Treat and extend regimen for diabetic macular oedema-a systematic review and meta-analysis[J]. Graefes Arch Clin Exp Ophthalmol, 2023, 261(2): 303-315. doi:10.1007/s00417-022-05770-y
[3] 郭菊, 刘珍慧, 潘萌, 等. 抗VEGF治疗对PDR患者玻璃体液中TGF-β及相关microRNA水平的影响[J].中华眼科杂志, 2021, 57(12): 922-929. doi:10.3760/cma.j.cn112142-20210317-00133 GUO Ju, LIU Zhenhui, PAN Meng, et al. The effect of anti-VEGF therapy on the expression levels of TGF-β and related microRNAs in the vitreous of patients with proliferative diabetic retinopathy[J]. Chinese Journal of Ophthalmology, 2021, 57(12): 922-929. doi: 10.3760/cma.j.cn112142-20210317-00133
[4] 史雪辉, 张丛, 魏文斌. 关注糖尿病黄斑水肿的光学相干断层扫描分型及相关影像特征[J/OL]. 中华眼科医学杂志(电子版), 2021, 11(1): 1-7. doi:10.3877/cma.j.issn.2095-2007.2021.01.001 SHI Xuehui, ZHANG Cong, WEI Wenbin. Pay attention to OCT-based classification and features of diabetic macular edema[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(1): 1-7. doi:10.3877/cma.j.issn.2095-2007.2021.01.001
[5] Carol Y.Cheung, 冉安然. 青光眼影像人工智能深度学习研究现状与展望[J]. 山东大学学报(医学版), 2020, 58(11): 24-32. doi:10.6040/j.issn.1671-7554.0.2020.1249 CHEUNG CY, RAN Anran. Artificial intelligence deep learning in glaucoma imaging: current progress and future prospect[J]. Journal of Shandong University(Health Sciences), 2020, 58(11): 24-32. doi:10.6040/j.issn.1671-7554.0.2020.1249
[6] Shahriari MH, Sabbaghi H, Asadi F, et al. Artificial intelligence in screening, diagnosis, and classification of diabetic macular edema: a systematic review[J]. Surv Ophthalmol, 2023, 68(1): 42-53. doi:10.1016/j.survophthal.2022.08.004
[7] 王韩影, 蒋炎, 王晴仪, 等. 光学相干断层扫描血管成像技术观察糖尿病性视网膜病变及糖尿病性黄斑水肿患者视网膜血流变化[J]. 上海交通大学学报(医学版), 2021, 41(2): 166-172. doi:10.3969/j.issn.1674-8115.2021.02.007 WANG Hanying, JIANG Yan, WANG Chingyi, et al.Detection of vessel density changes in eyes of patients with diabetic retinopathy and diabetic macular edema using optical coherence tomography angiography[J]. Journal of Shanghai Jiao Tong University(Medical Science), 2021, 41(2):166-172. doi:10.3969/j.issn.1674-8115.2021.02.007
[8] 李璐瑶, 李静, 李艳, 等. 地塞米松玻璃体内植入剂对不同糖尿病性黄斑水肿的疗效与安全性评价[J]. 中华眼科杂志, 2023, 59(5): 398-403. doi:10.3760/cma.j.cn112142-20220722-00355 LI Luyao, LI Jing, LI Yan, et al. Efficacy and safety of intravitreal dexamethasone implant in diabetic macular edema patients with and without prior vitrectomy: a retrospective cohort study[J]. Chinese Journal of Ophthalmology, 2023, 59(5): 398-403. doi:10.3760/cma.j.cn112142-20220722-00355
[9] 阿柏西普玻璃体内注射治疗糖尿病性黄斑水肿中国共识专家组. 阿柏西普玻璃体内注射治疗糖尿病性黄斑水肿中国专家共识(2021)[J]. 中华实验眼科杂志, 2021, 39(5): 369-375. doi:10.3760/cma.j.cn115989-20210202-00088 Chinese consensus expert group on intravitreal injection of afeptocept for the treatment of diabetic macular edema. Chinese expert consensus on intravitreal injection of afeptocept for the treatment of diabetic macular edema(2021)[J]. Chinese Journal of Experimental Ophthalmology, 2021, 39(5):369-375. doi:10.3760/cma.j.cn115989-20210202-00088
[10] 中华医学会眼科学分会眼底病学组, 中国医师协会眼科医师分会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2022年)[J]. 中华眼底病杂志, 2023, 39(2): 99-124. doi:10.3760/cma.j.cn511434-20230110-00018 Fundology group of the Eyes Science Branch of the Chinese Medical Association, Fundology group of the Eyes Physicians Branch of the Chinese Medical Association. Evidence-based guidelines for diagnosis and treatment of diabetic retinopathy in China(2022)[J]. Chinese Journal of Fundology, 2023, 39(2): 99-124. doi:10.3760/cma.j.cn511434-20230110-00018.
[11] Malerbi FK, Mendes G, Barboza N, et al. Diabetic macular edema screened by handheld smartphone-based retinal camera and artificial intelligence[J]. J Med Syst, 2021, 46(1): 8. doi:10.1007/s10916-021-01795-8
[12] Chakroborty S, Gupta M, Devishamani CS, et al. Narrative review of artificial intelligence in diabetic macular edema: Diagnosis and predicting treatment response using optical coherence tomography[J]. Indian J Ophthalmol, 2021, 69(11): 2999-3008. doi:10.4103/ijo.IJO_1482_21
[13] Lam C, Wong YL, Tang ZQ, et al. Performance of artificial intelligence in detecting diabetic macular edema from fundus photography and optical coherence tomography images: a systematic review and meta-analysis[J]. Diabetes Care, 2024, 47(2): 304-319. doi:10.2337/dc23-0993
[14] Vujosevic S, Limoli C, Nucci P. Novel artificial intelligence for diabetic retinopathy and diabetic macular edema: what is new in 2024?[J]. Curr Opin Ophthalmol, 2024, 35(6): 472-479. doi:10.1097/ICU.0000000000001084
[15] 赵明威, 孙摇遥, 许迅. 合理使用抗VEGF药物辅助治疗糖尿病视网膜病变[J]. 中华眼科杂志, 2019, 55(8): 565-568. doi:10.3760/cma.j.issn.0412-4081.2019.08.002 ZHAO Mingwei, SUN Yaoyao, XU Xun. The rational use of anti-vascular endothelial growth factor drugs to assist the treatment of diabetic retinopathy[J]. Chinese Journal of Ophthalmology, 2019, 55(8): 565-568. doi:10.3760/cma.j.issn.0412-4081.2019.08.002
[16] 陈有信, 杨景元. 人工智能大模型在眼科临床的应用[J].中华眼科杂志, 2024, 60(3): 303-306. doi:10.3760/cma.j.cn112142-20231211-00285
[17] 任邵杰, 徐嫚鸿, 李筱荣. 铁死亡参与糖尿病视网膜病变发病机制的研究进展[J].中华眼底病杂志, 2023, 39(10): 868-872. doi:10.3760/cma.j.cn511434-20220801-00430 REN Shaojie, XU Manhong, LI Xiaorong. Research progress of ferroptosis involved in the pathogenesis of diabetic retinopathy[J].Chinese Journal of Ocular Fundus Diseases, 2023, 39(10): 868-872. doi:10.3760/cma.j.cn511434-20220801-00430
[18] 余晓, 刘腾, 邹玉凌, 等. 视网膜下注射阿柏西普治疗难治性息肉样脉络膜血管病变疗效的初步研究[J]. 中华眼底病杂志, 2024, 40(2): 122-128. doi:10.3760/cma.j.cn511434-20231115-00457 YU Xiao, LIU Teng, ZOU Yuling, et al. Preliminary study on the efficacy of subretinal injection of Aflibercept in the treatment of refractory polypoidal choroidal vasculopathy[J]. Chinese Journal of Ocular Fundus Diseases, 2024, 40(2): 122-128. doi:10.3760/cma.j.cn511434-20231115-00457
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