JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2009, Vol. 23 ›› Issue (6): 18-.

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Expression and clinical significance of cox-2 protein in nasopharyngeal carcinoma

JING Qiancheng, LUO Zhiqiang, HE Xiusheng, ZHOU Yandan   

  1. 1. Department of Otorhinolaryngology, Affiliated Second Hospital of Nanhua University, Hengyang 421001, Hunan， China;
    2. Institute of Cancer Research， Nanhua University, Hengyang 421001, Hunan， China；3. Department of Ophthalmology,
    Affiliated Second Hospital of Zhejiang University, Hangzhou 310009, China
  • Received:2009-09-03 Revised:2009-11-30 Published:2009-12-16

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Abstract:

Objective  To investigate expression and its clinical significance of COX-2 protein in nasopharyngeal carcinoma. Methods  The immunohistochemical method and Western blot method were used to determine expression of COX-2 protein in specimens of 47 cases (33 cases by IHC and 14 by Western Blot ) of nasopharyngeal carcinoma and 24 cases of normal nasopharyngitis tissues. Results  Positive staining rate of COX-2 in specimens of nasopharyngeal carcinoma (81.8%) was significantly higher than that of normal nasopharyngitis tissues (25%)(P=0.001). Western Blot assay revealed that the relative COX-2 protein level was 1.258±0.034 and 0.487±0.076 respectively in the two tissues,which was significantly higher in nasopharyngeal carcinoma(P=0.000). Conclusion  Over-expression of COX-2 may play a crucial role in the carcinogenesis and progression of nasopharyngeal carcinoma, selectivity COX-2 inhibiter may become an important chemotherapy drug for nasopharyngeal carcinoma.

Key words:  Cox-2 protein; Nasopharyngeal carcinoma; Immunohistochemistry, Western blot

CLC Number: 

  • R739.65
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