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    16 December 2009 Volume 23 Issue 6
      
    Articles
    Application of image guidance system in anterior and middle skull base operations
    ZHANG Qingquan, SONG Xicheng, WANG Qiang, ZHANG Hua, SUN Yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  4-6. 
    Abstract ( 1330 )   PDF (358KB) ( 612 )   Save
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    Objective  To discuss the value of image guidance system in anterior skull base operations, and its assistance on avoiding the damage of important nerves and vessels of cranial fossa, lowering rate of surgical complications and raising the curative rate. Methods  We performed 112 operations with the help of image guidance system, which included operations on 19 patients with traumatic fractures of optic canals, 15 with cerebrospinal rhinorrhea, 26 with tumors of middle skull base (3 with fibrous dysplasia, 6 with squamous cell carcinoma of sphenomaxillary fossa and middle skull base, 1 with metasellar neurofibroma, 4 with ostoma of posterioriethmoid and skull base and 12 with hypophysoma), 17 with sphenoid sinus cyst involving intracranial structure, 11 with mycotc sphenoiditis,18 with isolated sphenoiditis, and 6 with posterioriethmoiditis, sphenoiditis and nasal polyps. Results  Image guidance system was well configured in all 112 patients and with its help we can find the fracture, ventage or apertures, and the boundary in patients with tumors, and we can also locate the surrounding vital structures thus avoiding harming them. Conclusions  Image guidance system can help us accurately and clearly locate the destination and lower the rate of surgical complications, and excise the pathological tissues to the maximum extent, and compensate for the lack of 3 dimension locating of nasal endoscopes. But image guidance system is setup on preoperative images and can not reflect the change in the surgery. Accurate configure is the key to image guidance system and if the corresponding position is damaged, catastrophic results maybe occurs, so it is important to check the system timely.

    Application of an image guidance system  in complex endoscopicendo-nasal skull base surgery
    WANG Yinfeng, SUN Jingwu, LV Qiuping, WAN Guanglun, GUO Tao
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  10-12. 
    Abstract ( 1273 )   PDF (366KB) ( 519 )   Save
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    To evaluate the effectiveness of an image-guided navigation system (IGNS) in complex endoscopic sino-nasal and anterior skull base surgery. Methods26 patients who underwent image-guided endoscopic surgery were involved in this study, including 2 patients with recurred frontal sinus inverted papilloma, 5 with nasal cavity and sinuses neoplasms that extended to the skull base, 7 with pituitary adenomas and 12 with traumatic diseases of the optic nerve. ResultsPreparation of intra-operative imaging guided navigation system (including registering, head rest positioning, and surgical instruments registration ) needed 5~10min (mean 7min). The localization error of image landmarks was less than 1.5mm to the entity anatomic landmarks. All operative procedures were successfully performed without any intra-operative or post-operative complications. ConclusionsIGNS provides  accurate anatomical localization, it can help the operator to make certain the locations of important anatomic structures in the operative region and to decide the excision extent for neoplasm in real time, so as to remove the neoplasm to the utmost extent and decrease the occurrence of complications. IGNS reinforces the self-confidence of the operators and enhances security of the operation,  especially when the patient has a history of operation or anatomic landmarks of the skull base are destroyed by sino-nasal disease.

    Application of an image-guided system in endoscopic sinus surgery in  treatment of sphenoid sinus lesions
    SUN Yan, SONG Xi-cheng, ZHANG Qing-quan, ZHU Yu-hong, ZHANG Hua, WANG Qiang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  13. 
    Abstract ( 1623 )   PDF (324KB) ( 399 )   Save
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    Objective  To explore and estimate the value of an image-guided system in endoscopic sinus surgery for sphenoid sinus lesions. Methods   37 cases of sphenoid sinus diseases, involving 21 cases of sphenoid sinusitis, 6 of caseous rhinitis and 10 sphenoid sinus cyst (6 patients with mucocele and 4 patients with mucosa cyst) accepted treatments with an image-guided system in endoscopic sinus surgery. All were operated on with general anesthesia with tracheal intubation, guidance of the image-guided system to calibrate the probes or aspirators, and endoscopy to remove the lesions. For cases with sphenoid sinus mucocele, the anterior or the anterior inferior wall was  perforated by a hole of 1cm×0.5cm. For cases with mucosa cyst of the sphenoid sinus, the cyst was removed. Results  All the 37 patients were successfully cured without serious complications during and after the operations. Conclusions  The image-guided system in endoscopic sinus surgery can be effectively used to remove sphenoid sinus lesions for improving surgical curative effect and avoiding complications.

     Application of image guidance in the surgical treatment of nasal inverted papilloma
    JIANG Shaohong, ZHU Yuhong, WANG Qiang, WANG Wenyi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  15. 
    Abstract ( 1364 )   PDF (357KB) ( 501 )   Save
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    Objective  To evaluate the application of image guidance in the surgical treatment of nasal inverted papilloma . Methods  Sixty-eight patients with nasal inverted papilloma were hospitalized and underwent operations. They were divided into two groups. Group 1 were hospitalized from May 2001 to Dec. 2004 and all underwent endoscope or/and classic operation. Group 2 were hospitalized from Jan. 2005 to June 2007, and all underwent endoscope or/and  classic operation  using an image guidance technique. Results  The relapse rate of group 2 was significantly lower than that of group 1(P<0.05).  Conclusion  Image guidance technique helps to reconstruct the 3d structure with accurate positioning. It is not influenced by tissue displacement and complicated anatomical structure, so it can strikingly lower the relapse rate.

    Expression and clinical significance of cox-2 protein in nasopharyngeal carcinoma
    JING Qiancheng, LUO Zhiqiang, HE Xiusheng, ZHOU Yandan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  18. 
    Abstract ( 1452 )   PDF (435KB) ( 473 )   Save
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    Objective  To investigate expression and its clinical significance of COX-2 protein in nasopharyngeal carcinoma. Methods  The immunohistochemical method and Western blot method were used to determine expression of COX-2 protein in specimens of 47 cases (33 cases by IHC and 14 by Western Blot ) of nasopharyngeal carcinoma and 24 cases of normal nasopharyngitis tissues. Results  Positive staining rate of COX-2 in specimens of nasopharyngeal carcinoma (81.8%) was significantly higher than that of normal nasopharyngitis tissues (25%)(P=0.001). Western Blot assay revealed that the relative COX-2 protein level was 1.258±0.034 and 0.487±0.076 respectively in the two tissues,which was significantly higher in nasopharyngeal carcinoma(P=0.000). Conclusion  Over-expression of COX-2 may play a crucial role in the carcinogenesis and progression of nasopharyngeal carcinoma, selectivity COX-2 inhibiter may become an important chemotherapy drug for nasopharyngeal carcinoma.

    Management and prevention of pharyngeal fistula after surgery for larynx and lower pharynx cancer
    GAO Yingkai1,ZHANG Fengying1,WANG Shuyong1,LIU Qingming2,CHEN Shuping1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  21-23. 
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    Objective  To discuss the management and prevention of pharyngeal fistula after surgery for larynx and lower pharynx cancer.  Methods  5 patients had pharyngeal fistula after laryngectomy and 2 were treated by surgery. 11 patients had pharyngeal fistula after lower pharynx cancer resection and  2 were treated by surgery.  Results  Among the 5 patients with pharyngeal fistula after laryngectomy,3 were cured by dressing change and 2 by pectoralis major myocutaneous flap neoplasty. Among the 11 patients with pharyngeal fistula after lower pharynx cancer resection,9 were cured by dressing change after 2 to 4 weeks and 2 were treated by dressing change for 4 weeks and then were cured by suture. Conclusion   Pharyngeal fistula after surgery of larynx and lower pharynx cancer is one of the serious complications. Most patients can be cured by dressing change and some must be treated by surgery. It is necessary to take some measurements before, during and after operation.

    Prediction of  bone-conduction of audiometric threshold in normal-hearing adults using multiple auditory steady state response
    TIAN Chenghua, WANG Yonghua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  31. 
    Abstract ( 1460 )   PDF (365KB) ( 1440 )   Save
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    Objective  To explore the prediction of bone-conduction of audiometric(BC-A) threshold in normal-hearing  adults using multiple auditory steady-state response(ASSR). Methods  BC-ASSR and BC-A were recorded in 20 normal-hearing adults(10 males and 10 females). The response thresholds and the behavioral thresholds were compared at 0.5, 1.0, 2.0 and 4.0kHz to get the correlation and regression formulae. Results  There were no significant differences between the men and women for the response thresholds. There was a significant difference at 4kHz for BC-ASSR. At the other three frequencies, no significant differences were found. Pearson correlation coefficients between the response thresholds and the behavioral thresholds were 0.95, 0.91, 0.26 and 0.29 at 0.5, 1.0, 2.0 and 4.0kHz. Conclusion  BC-ASSR can only be used to predict the BC-A  at 0.5 and 1.0kHz. The correlation between the response thresholds of BC-ASSR and BC-A is not strong.

    Application of different techniques and materials to  myringoplasty
    XIAO Huiliang1,ZHANG Weihua1, QU Yongkang2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  35-37. 
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    ObjectiveT  o evaluate the outcomes of myringoplasty for various specific kinds of perforations of the ear drum via endotoscope or operating microscope with different materials.  Methods  109 patients(109 ears) with perforations of the ear drum were recruited from November 2007 to March 2009 . The patients were divided into 3 groups according to the size and position of perforations of the ear drum: 31 accepted myringoplasties with a fat plug , 43 accepted perichondrium via  endotoscope, and 35 accepted fascia musculares via an operating microscope.  Results  After a follow up of 6~18 months, the healing rates of perforations of the ear drum in the three groups were 90.3 %, 90.7% and 91.4%, respectively.  Average pure-tone hearing thresholds improved significantly after operation in each group(P<0.05).  Conclusions   According to the size and position of perforations of the ear drum, we can select endotoscope or operating microscope  and different materials for myringoplasty. For central type of perforations, the application of endotoscope with fat plug or perichondrium is reliable  and  minimally invasive.

    Titanium mesh applied in 32 cases of open method tympanoplasty
    MA Rongchang, LI Dajun, LI Wujie
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  38-40. 
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    Objective  To investigate the effect of open method tympanoplasty combined with mastoid obliteration and titanium mesh and the reconstruction of the attic wall. Methods  32 cases of cholesteatoma or skeletal ulcer otitis media accepted the open method tympanoplasty combined mastoid obliteration and titanium mesh and reconstruction of the attic wall after radical mastoidectomy. Results  The external auditory canals of 30 ears were normal in appearance. The transplanted membrane in 29 ears survived. The dry-ears rate was 90.62% and the average time till dry-ears was 15.89±4.02 days. The air-conducting hearing levels of average language frequency were enhanced by over 15dBHL in 27 ears. An air-bone gap of less than 20dBHL was achieved in 22 ears. Conclusion  The anatomical structure and physiological function of the external auditory canal and middle ear can recover after the above mentioned treatment with a satisfactory long-term effect in improving hearing.

    Clinical analysis on perioperative medication for endoscopic sinus surgery of  892 cases of chronic rhinosinusitis
    DENG Xiangkun1, LI Xuezhong2, QIU Zhihong1, WANG Jinquan1, DENG Xiuyu1, FU Lihua1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  45-48. 
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    Objective  To explore the peri-operative treatments and notes of endoscopic sinus surgery.  Methods  The follow-up results and treatment effects after 1 year  of endoscopic sinus surgery were analyzed.  Results   Based on the chronic rhinosinusitis diagnosis and treatment guidelines of Nanchang 2008, a quantitative assessment with an endoscopic examination was made by Lund-Kennedy Scoring at 1 year after the operation. In 892 cases, 759 cases were cured(82.5%), 133 cases were improved(15%), 22 cases were not improved(2.5%). These patients all had chronic rhinosinusitis with co-morbidity of the nasal polyps. Complications of endoscopic sinus surgery included 27 cases of injury of the lamina papyracea,11 cases of cerebrospinal rhinorrhea, 1 case of hemorrhea after the operation, and 6 cases of injury of the ethmoid roof. Most of these occurred at an early stage after the surgeries.  Conclusions  Prevention of operational complications and improvement of the effect depends on rigorous peri-operative treatments, follow-up and endoscopic dressing.

    Fungal maxillary sinusitis treated by endoscopic sinus surgery and  endoscopy by dual approaches
    HAN Fei, CUI Xinhua, GU Lintao, WANG Qirong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  49-50. 
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    Objective  To compare the treatment effect on fungal maxillary sinusitis by simple endoscopic sinus surgery and  endoscopy by dual approaches(Caldwel-Luc type and natural ostium of maxillary sinus).  Method  Thirty cases were operated on by functional endoscopic sinus surgery and twelve cases were operated on by dual approaches under endoscopic sinus. Result  All cases were cured without  noticeable complications in a follow-up of three to six months. Conclusion  Dual approaches under endoscopy can achieve satisfactory effects without more complications .

    Treatment of endoscopic sinus surgery before and after operation
    LI Honghui, YAO Xiaobao, LI Suiqin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  51. 
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    Objective  To explore the influence of functional endoscopic sinus surgery performed before and after operation on the efficacy of treatment.  Methods  101 cases of sinus surgery were reviewed and the effect was analyzed on preoperative preparation, anesthesia, surgical approach and postoperative management. Results  All the 101 patients, including 3 who accepted reexamination, had a good recovery. Conclusion  The appropriate preoperative and postoperative treatment is important for reducing complications and increasing the curative rate.

    Clinical application of thyrocricocentesis and thyrocricotomy
    CAI Qian,GUAN Zhong,ZHANG Zhigang,HUANG Xiao-ming,ZHENG Yiqing, SUN Wei,CHEN Bin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  57-58. 
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    Objective  To study the clinical application of thyrocricocentesis and thyrocricotomy.  Methods  Patients with IVdegree dyspnea were rescued with surgery, including thyrocricocentesis on 19 patients (15 before and 4 during tracheotomy) and thyrocricotomy on 6 patients.  Results  All the 19 patients accepting  thyrocricocentesis were successfully saved. Though tracheal cannula was successfully intubed in all 6 patients accepting thyrocricotomy, 3 patients died in one hour,1 died 24 hours later due to multiple organ failure, and 2 were alive and accepted tracheotomy after their condition was stable.  Conclusion  Thyrocricocentesis combined with tracheotomy can remove airway obstruction in most patients with IV-degree dyspnea. Thyrocricotomy is applicable to patients whose blood oxygen saturation is <90% and declined progressively and rapidly, and patients with suffocation induced by upper airway hemorrhea, and patients with sudden cessation of breath.

    Comparison of two types of anesthesia used for tracheal incision and intubation
    WANG Xueqin , LI Jianjun , ZHOU Changqing
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  59-61. 
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    Objective  To investigate if midazolam combined with remifentanil could  provide a good condition for tracheal incision and intubation with less intubation responses and awareness .  Methods   30 ASA Ⅰ or Ⅱ laryngocarcinoma patients aged 35-55 yrs were randomly divided into 2 groups ( n = 30 each) according to the types of anesthesia for tracheal incision and intubation: patients of group I received innovar 2mL before tracheal incision, while those of group R received midazolam 50μg·Kg-1 followed by a constant infusion of remifentanil(0.05 μg·Kg-1·min-1 ). Tracheal incision was achieved under local infiltration anesthesia. Just before tracheal intubation, all patients assigned to group I received innovar 2mL, while patients assigned to group R received remifentanil 1μg·Kg-1.   MAP, HR and SpO2 were monitored and recorded before local infiltration anesthesia (T0),  before tracheal intubation (T1), at the moment of tracheal intubation success  (T2), and two minutes after anesthesia induction (T3). Propofol used for anesthesia induction  was recorded as well. Responses such as restlessness and coughing were also recorded . The patients′ awareness of tracheal incision and intubation was recorded after operation . Results   As compared with the baseline values at T0, MAP and HR were significantly increased at T2 (P<0.05), while MAP and HR at T3 were significantly decreased  in group I(P<0.05); In group R, HR at T3 were significantly decreased(P<0.05). As compared with group I, HR and  MAP at T2 in group R were significantly decreased(P<0.05), while MAP at T3 were significantly increased(P<0.05). Propofol used for anesthesia induction was much higher in group I than that in group R(P<0.01). The incidences of tracheal intubation responses such as coughing and restless were significantly higher in group I than that in group R(P<0.01). The incidence of awareness was significantly lower in group R than that in group I(P<0.01) . Conclusion   Midazolam combined with remifentanil can provide a good condition for tracheal incision and intubation with less intubation responses and awareness .

    Protection of basic fibroblast growth factor on optic nerve axons in high intraocular pressure animal models
    XIE Lijuan1, LI Yun1, GONG Lei1, XIAO Ying2, YANG Xiaoran1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  62-66. 
    Abstract ( 1103 )   PDF (688KB) ( 630 )   Save
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    Objective  To evaluate the protective effect of basic fibroblast growth factor on optic nerve axons in high intraocular pressure of rabbits. Methods  Of the 22 rabbits (44 eyes), 2 rabbits (4 eyes) were  the  normal control group without receiving any injection. Carbomer was randomly injected into the other 20 rabbits′ (40 eyes) anterior chambers to make high intraocular pressure (IOP) models. 50μL of bFGF (2000U) was injected into one vitreous chamber of each rabbit randomly (bFGF therapy eyes), and the same volume of PBS into the other vitreous chambers (surgery control eyes) when making high IOP models and on days 7, 14 and 21 after it.  The optic disc of the ocular fundus, cyathus/disc area ratio, number and morphology of optic nerve axons were observed in each period. Ultrastructural changes of optic nerve axons were observed on the 28th day. Results  The optic disc became pale, umbilication became deep and blood vessels became curved on the 14th day, and the optic disc obviously changed on the 21st day in the surgery control eyes. C/DAR changes in bFGF therapy eyes were less than those in surgery control eyes(P<0.05) on the 14th day. The number of optic nerve fibers in bFGF therapy eyes was more than that in surgery control eyes (P<0.01). Electron microscope examination showed that the arrangement of axons was disordered and the myelinic membrane denatured and apoptosis was frequently  in surgery control eyes, and that the structure of axons was approximately normal in bFGF therapy eyes on the 28th day. Conclusion  In high intraocular pressure animal models, bFGF can protect the optic nerve axons.

    Trabeculectomy with mitomycin-C and amniotic membrane transplantation  and  adjustable suture for  refractory glaucoma
    WANG Zhen,SHEN Jiaquan,ZHANG Shixi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(6):  67-70. 
    Abstract ( 1401 )   PDF (384KB) ( 526 )   Save
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    Objective   To investigate the effects of trabeculectomy with mitomycin-C and amniotic membrane transplantation and  adjustable suture for  refractory glaucoma.  Methods   38 cases(44 eyes) with  refractory glaucoma  trabeculectomy were divided  into  three groups: the amniotic membrane transplantation and mitomycin C ((AMT and MMC) group (16 eyes),  the MMC group (14 eyes) and control group (14 eyes).  Adjustable suture was applied to all the patients. The operative intraocular pressure (IOP),  filtering bubbles,  anterior chamber depth  and postoperative complications were determined and recorded 1 week, 2 weeks, 6 months and 12 months after operation.  Results   The postoperative IOP, filtering bubbles,  anterior chamber depth and postoperative complications in the AMT and MMC group were better than those of the control group(P<0.01).The postoperative complications in the AMT and MMC group were rare, mainly involving the shallow anterior chamber; but in the MMC group they were mainly thin wall filtering bubble, or bubble leaking etc.  Conclusion   Trabeculectomy with Mitomycin-C and amniotic membrane transplantation and adjustable suture is an effective method to treat glaucoma. Amniotic membrane transplantation has  the effects of anti-neovacularization ,anti-scarring agent,and mechanical drainage in early time.