Abstract:

Objective   To investigate the effects of trabeculectomy with mitomycin-C and amniotic membrane transplantation and  adjustable suture for  refractory glaucoma.  Methods   38 cases(44 eyes) with  refractory glaucoma  trabeculectomy were divided  into  three groups: the amniotic membrane transplantation and mitomycin C ((AMT and MMC) group (16 eyes),  the MMC group (14 eyes) and control group (14 eyes).  Adjustable suture was applied to all the patients. The operative intraocular pressure (IOP),  filtering bubbles,  anterior chamber depth  and postoperative complications were determined and recorded 1 week, 2 weeks, 6 months and 12 months after operation.  Results   The postoperative IOP, filtering bubbles,  anterior chamber depth and postoperative complications in the AMT and MMC group were better than those of the control group(P＜0.01).The postoperative complications in the AMT and MMC group were rare, mainly involving the shallow anterior chamber； but in the MMC group they were mainly thin wall filtering bubble, or bubble leaking etc.  Conclusion   Trabeculectomy with Mitomycin-C and amniotic membrane transplantation and adjustable suture is an effective method to treat glaucoma. Amniotic membrane transplantation has  the effects of anti-neovacularization ,anti-scarring agent,and mechanical drainage in early time.

Key words: Amniotic membrane transplantation；Mitomycin C；Trabeculectomy；Refractory  glaucoma