JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2010, Vol. 24 ›› Issue (2): 26-29.

• Articles • Previous Articles     Next Articles

 Expressions of SOCS3 and Eotaxin-2 in allergic rhinitis

WANG Xinlong1， ZHAO Jiandong2   

  1. 1.  School of Medicine，Shandong University，Jinan 250012，China；
     2. Department of Otolaryngology，Second Affiliated Hospital，Shandong University，Jinan 250033，China
  • Received:2010-03-09 Revised:2010-03-24 Online:2010-04-16 Published:2010-04-16

PDF (PC)

1308

Abstract:

Objective  To investigate expressions of SOCS3 and Eotaxin-2 in allergic rhinitis(AR)． Methods  Twenty cases of allergic rhinitis nasal mucosa tissues served as the experimental group and fifteen cases of deflection of nasal septum nasal mucosa tissues as the control group．Immunohistochemisty was performed to detect expressions of SOCS3 and Eotaxin-2．The relationship between SOCS3 and Eotaxin-2 expressions was analyzed．Results  SOCS3 and Eotaxin-2 expressions were increased in the AR patients．There were positive staining in inflammatory cells, vascular endothelial cells，epithelial cells and glandular epithelium cells．Compared with the control group，expressions of SOCS3(0.2401±0.01463) and of Eotaxin-2(0.2398±0.01423) significantly higher than those in the control group(P<0.01). The SOCS3 expression was closely related to Eotaxin-2 expression(r=0.951,P<0.01).      Conclusion  Increased expressions of SOCS3 and Eotaxin-2 in allergic rhinitis are well evidenced. SOCS3 shows positive correlation with Eotaxin-2.

Key words: Rhinitis， allergic； SOCS3； Eotaxin-2

CLC Number: 

  • R765．21
[1] WANG Chang-qing1, LI Xin-ping1, ZHAO Wen-min1, WANG Zhong1, ZENG Hong-bin1, ZHANG Hua1, LIU Li-zhong2.. Analysis and research of clinical features of aspirin intolerance triad [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 45-47.
[2] ZHANG Xia1, XIA Li-jun2. A follow-up study of quality of life of 120 cases of chronic nasalsinusitis after endoscopic sinus surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 51-54.
[3] GAO Rong-li1， DING Jian2, ZANG Yan-wei3, YAN Shu1, LIU Ting-ting1, LIU Zan-gang4, GONG Xiang-gui5， ZHOU Xiao-bin6, LI Na1, ZHANG Nian-kai1. Epidemiological investigation of allergic rhinitis in the Qingdao area [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 55-60.
[4] CHEN Fang, LI Xiao-yan.. Advances in T-bet and TGF-β in allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 83-86.
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 66-67.
[6] CHEN Min, LI Na. SELDI protein-chip technology for identification of different protein expression in serum between allergic rhinitis and nasal polyposis patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 41-44.
[7] LI Wei1, GAN Min1, LIU Shang-yao1, ZHU Feng-hua1, DU Ming1, ZHAO Jian-dong2. Effect of the costimulatory  pathway  OX40 /OX40L  on  pathogenesis of allergic  rhinitis  in  mice [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 45-47.
[8] FANG Jian-lin, GAO Xing-qiang, ZHAO De-an. Expressions of Toll-like receptor 2，Toll-like receptor 3 and Toll-like receptor 4 in experimental allergic rhinitis in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(4): 40-44.
[9] MENG Qinghua, XIE Jinghua, SU Fang, WANG Lei. Detection of EOS in nasal section of the early stage in patients with allergic rhinitis treated with sublingual specific immunotherapy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(3): 36-39.
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(2): 41-42.
[11] HUANG Zhiqin. Functional and trans-nasal endoscopic management of nasal cavity structures in treatment of structural rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(01): 34-36.
[12] KUANG Jia-Li, TUN Jun, GUO Liang, FANG Xiang-Jia. Sublingual immunotherapy on allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(4): 49-51.
[13] Li-Qin ,Ma Yan-Yan, CHEN Yan-Lin, DU Yang-Hua, ZHANG Yong-Dong, WU Cai-Xia. Effect of GATA3 on IL-4 and IL-5 in rats with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(6): 520-522.
[14] BAO Ai-chun1, GONG Qi1, SHI Kui1, SUN Zhen-feng2, DONG Pin2. Relationship between atopic factors and asthma and combined allergic rhinitis and asthma syndrome in children [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(6): 36-38.
[15] SUN Yan, SONG Xi-cheng, ZHANG Qing-quan, ZHU Yu-hong, ZHANG Hua, WANG Qiang. Application of an image-guided system in endoscopic sinus surgery in  treatment of sphenoid sinus lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(6): 13-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd