下咽癌FADU细胞系中CD133阳性细胞侵的袭能力

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2010, Vol. 24 ›› Issue (2): 5-7.

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Invasion of the CD133-positive cells in FADU cell line

LIANG Hui1,2, PAN Xinliang1, MA Chao3, WANG Qirong2, HAN Fei2, CUI Zhaoyang2

1. Department of Otorhinolaryngology， Qilu Hospital of Shandong University， Jinan 250012, China;
2. Department of Otorhinolaryngology， Qian Foshan Hospital of Shandong University， Jinan 250014, China;
3. Key Laboratory of the Ministry of Health ENT, Shandong University, Jinan 250012, China

Received:2010-01-19 Revised:2010-03-08 Online:2010-04-16 Published:2010-04-16

Abstract

Abstract:

Objective To investigate the invasion of the CD133-positive cells in FADU cell line. Methods In our study, Immunomagnetic beads were applied to purify CD133-positive cells in FADU cell line. Invasions of CD133-positive and CD133-negative cells were measured by the Transwell experiment. Results The number of cells infiltrating the Transwell membrane in the CD133-positive group (54±2.3) was significantly higher than that in the CD133-negative group (17±1.1). Conclusion CD133-positive cells in FADU cell line show higher invasive ability.

Key words: Hypopharyngeal Cancer; Neoplastic Stem cells; Invasion; CD133

CLC Number:

R739.63

LIANG Hui1,2, PAN Xinliang1, MA Chao3, WANG Qirong2, HAN Fei2, CUI Zhaoyang2. Invasion of the CD133-positive cells in FADU cell line[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(2): 5-7.

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