JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2010, Vol. 24 ›› Issue (4): 30-33.

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Expressions of heparanase and nm23-H1 protein and their relationship with invasion and metastasis in nasopharyngeal carcinoma

ZHU Guo-chen, ZHANG Yong-sheng, ZHENG Xiao-bin, XIAO Da-jiang   

  1. Department of Otolaryngology & Head and Neck Surgery, Wuxi Second People′s Hospital,
    Nanjing Medical University, Wuxi 214002, Jiangsu, China
  • Received:2010-04-20 Revised:2010-07-02 Online:2010-08-16 Published:2010-08-16

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Abstract:

Objective    To investigate expressions of heparanase and nm23-H1 protein in nasopharyngeal carcinoma (NPC) as well as their relationship with clinicopathological factors. Methods    Expressions of heparanase and nm23-H1 protein in 60 cases of NPC with poor differentiation and 20 cases of chronically inflammatory tissues of nasopharynx were determined by immunohistochemical staining. Results     The positive rate of heparanase protein in tumor tissues was 55% (33/60), which was significantly higher than that in inflammatory tissues (P<0.05). The heparanase protein expression was significantly related to TNM stage, local lymph nodes and distant metastasis of NPC (P<0.05). The positive rate of nm23-H1 protein in tumour tissues was 53.3% (32/60), significantly lower than that in inflammatory tissues (P<0.05), and the nm23-H1 protein expression was significantly related to clinical stage, local lymph nodes and distant metastasis of NPC(P<0.05). Expression of heparanase protein had a significantly negative correlation with that of nm23-H1 protein in NPC. Conclusion    The positive expression of heparanase and the negative expression of nm23-H1 may be significantly related to the invasive infiltration and metastasis in NPC.

Key words: Nasopharyngeal neoplasms；  Heparanase；  nm23-H1；  Invasive infiltration；  Metastasis

CLC Number: 

  • R739．63
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