JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2010, Vol. 24 ›› Issue (4): 40-44.

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Expressions of Toll-like receptor 2，Toll-like receptor 3 and Toll-like receptor 4 in experimental allergic rhinitis in rats

FANG Jian-lin, GAO Xing-qiang, ZHAO De-an   

  1.  Department of Otolaryngology&Head and Neck Surgery, Xiamen First Hospital Affiliated toFujian Medical University, Xiamen 361003, Fujian, China
  • Received:2010-03-19 Revised:2010-05-25 Online:2010-08-16 Published:2010-08-16

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Abstract:

Objective    To observe expressions of toll-like receptor 2 (TLR2), toll-like receptor 3 (TLR3) and toll-like receptor 4 (TLR4) in experimental allergic rhinitis(AR). Methods    46 Wistar rats were randomly divided into three groups: the AR group ( group A) was immunized by intra-peritoneal injection and intra-nasal instillation of ovalbumin (OVA); The normal control group ( group B) was administered by intra-peritoneal injection and intra-nasal instillation of physiological saline; The other six rats (group C) remained as an untouched healthy control group. Expressions of TLR2,TLR3 and TLR4 were determined by immunohistochemistry in rat nasal mucosa of all the groups. Results    The animal models of allergic rhinitis were successfully made in group A. TLR2 expressed in all the groups. TLR3 showed no expression in three groups. TLR4 expressed in group A, but not in the other two groups. Expressions of TLR2 and TLR3 in all the groups showed no significant difference (P>0.05) . Expression of TLR4 in group A was significantly higher than that in groups B and C (P<0.05 ) . Conclusion    Expression of TLR4 is increased in rat nasal mucosa with experimental allergic rhinitis, which suggests that TLR4 has an effect on allergic inflammation. Expressions of TLR2 and TLR3 showed no difference in all groups.

Key words: Rhinitis, allergic； Toll-like receptors； Nasal mucosa； Rats, Wistar

CLC Number: 

  • R765.21
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