Abstract:

Objective       To explore and analyze the relationship of transtympanic administration effect with inner ear MRI visualization in patients with Meniere′s disease and idiopathic sudden hearing loss. Methods       17 cases (13 cases of idiopathic sudden hearing loss and 4 cases of Meniere′s disease)were enrolled in the study. Gadolium, dexamethason or gentimycin were transtympanically  injected, and all patients were scanned with MRI 1h， 1d， and 6d after operation. The relationship of the effect with MRI visualization was observed and analyzed. Results       9 cases(5 cases of idiopathic sudden hearing loss and 4 cases of Meniere′s disease) of the 17 had inner ear high signal 1h to 6d after gadolium was injected. The other 8 cases had neither signal in the inner ear nor improved hearing. Conclusion    If transtympanically injected gadolium can permeate into the inner ear, dexamethoson and gentimycin would also permeate into it, and the therapy would have a good effect.

Key words: Inner ear；Transtympanic infuse； Meniere′s desease；Deafness，sudden