Objective To evaluate patient-controlled intravenous analgesia for endoscopic sinus surgery and its effect on cytokines IL-6 and IL-10. Methods 40 patients(ASAⅠⅡ) undergoing elective endoscopic sinus surgery were randomly divided into two groups: GroupⅠ (n=20, Sufentanil 0.002mg/kg normal saline diluted to 100mL )and Group Ⅱ (n=20, Nimesulide 0.1g,P.O,when VAS>4 or analgesic requirements in patients). Differences of VAS, blood pressure, blood oxygen, heart rate, breathing and adverse reactions were compared between the two groups at each time point. Blood serum concentrations of IL-6 and IL-10 were measured before and at postoperative 8h, 24h and 48h. Results Satisfaction with the analgesic effect of the groupⅠ.VAS score: group Ⅱ was significant higher than group Ⅰ（P<0.05）. No significant differences between the two groups were found in blood pressure, blood oxygen, heart rate, breathing （P>0.05）.There was a significant increase in the levels of IL-6 and IL10 in both groups comparing with those before anesthesia（P<0.05）, IL-6 in group Ⅱ increased significantly compared with that in the group Ⅰ at post-operative time points（P<0.05）, IL-10 in the group Ⅰ increased significantly compared with that in the group Ⅱ at post-operative time points (P<0.05). Conclusion Intravenous patient-controlled analgesia in endoscopic sinus surgery has a good analgesic effect，which can provide efficient effect in maintaining the balance of pro/antiinflammatory cytokines, and ease postoperative immune injury.