JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (4): 8-12.

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Significance of apoptotic and proliferative indices and  P-glycoprotein expression in laryngeal squamous cell carcinoma

LI Da-wei, DONG Pin, GAO Shang   

  1. Department of Otolaryngology-Head & Neck Surgery, Shanghai Jiaotong University  Affiliated First People′s Hospital, Shanghai 200080, China
  • Received:2011-02-28 Revised:2011-05-22 Online:2011-08-16 Published:2011-08-16

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Abstract:

Objective      To explore the relationship of P-glycoprotein  expression with the  apoptotic index, proliferative index, clinicopathological  characteristics, and their prognostic values in laryngeal squamous cell carcinoma (LSCC). Methods      Samples from 86 patients with LSCC were analyzed for P-glycoprotein and Ki67 expression with immunohistochemistry, and the apoptotic index with the TUNEL method. The association of P-glycoprotein  expression with clinicopathological  parameters, apoptotic and proliferative activities, and patients′ overall survival was subsequently analyzed. Results    It was found that up-regulation of P-glycoprotein expression was associated with decreased apoptosis (P＜0.05) but not with the changes in proliferation (P＞0.05). Expression of P-glycoprotein was significantly related to the clinical stage, histological grading, lymph node metastasis and overall survival in LSCC (P＜0.05). Conclusion      These results show that the overexpression of P-glycoprotein may abrogate the apoptosis of LSCC cells. Furthermore, the  results demonstrate that P-glycoprotein is predictive of malignant progression and prognosis of LSCC.

Key words: Laryngeal neoplasms; P-glycoprotein; Apoptosis; Cell proliferation; Prognosis

CLC Number: 

  • R739.65
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