JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2012, Vol. 26 ›› Issue (1): 41-43.

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Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma

WU Gui-qing1,  TIAN Jun2, SUN Jing1, CHEN Qi1. 1   

  1. Department of Otolaryngology， Weifang Medical College， Weifang 261053， Shandong， China； 2. Department of Otolaryngology， Weifang People′s Hospital， Weifang 261041， Shandong， China
  • Received:2011-07-13 Online:2012-02-16 Published:2012-02-16

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Abstract:

Objective   To observe the expression of Tiam1 and MTA1 in human laryngeal squamous cell carcinoma and its relationships with clinical-pathological features. Methods   The expression of Tiam1 and MTA1 in 46 human laryngeal squamous cell carcinoma (group A) and 10 tumor-adjacent normal larynx tissue (group B) were detected by immunohistochemistry. Results   The expression of Tiam1 and MTA1 was higher in group A than that in group B (P<0.01). Expression of Tiam1 was correlated with clinical staging, lymph node metastasis, but not age, sex or pathologic staging. Expression of MTA1 was correlated with clinical staging, lymph node metastasis and pathologic staging, but not age or sex. The expression of Tiam1 was positively correlated to that of MTA1 in group A . Conclusions   Tiam1 and MTA1 may be correlated with invasion and metastasis of laryngeal carcinoma,  and it is useful for diagnosis, treatment and prognosis.

Key words: Laryngeal squamous cell carcinoma；  Tiam1； MTA1； Immunohistochemistry

CLC Number: 

  • R739.65
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