JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2012, Vol. 26 ›› Issue (1): 41-43.

• Articles • Previous Articles     Next Articles

Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma

WU Gui-qing1,  TIAN Jun2, SUN Jing1, CHEN Qi1. 1   

  1. Department of Otolaryngology， Weifang Medical College， Weifang 261053， Shandong， China； 2. Department of Otolaryngology， Weifang People′s Hospital， Weifang 261041， Shandong， China
  • Received:2011-07-13 Online:2012-02-16 Published:2012-02-16

PDF (PC)

1254

Abstract:

Objective   To observe the expression of Tiam1 and MTA1 in human laryngeal squamous cell carcinoma and its relationships with clinical-pathological features. Methods   The expression of Tiam1 and MTA1 in 46 human laryngeal squamous cell carcinoma (group A) and 10 tumor-adjacent normal larynx tissue (group B) were detected by immunohistochemistry. Results   The expression of Tiam1 and MTA1 was higher in group A than that in group B (P<0.01). Expression of Tiam1 was correlated with clinical staging, lymph node metastasis, but not age, sex or pathologic staging. Expression of MTA1 was correlated with clinical staging, lymph node metastasis and pathologic staging, but not age or sex. The expression of Tiam1 was positively correlated to that of MTA1 in group A . Conclusions   Tiam1 and MTA1 may be correlated with invasion and metastasis of laryngeal carcinoma,  and it is useful for diagnosis, treatment and prognosis.

Key words: Laryngeal squamous cell carcinoma；  Tiam1； MTA1； Immunohistochemistry

CLC Number: 

  • R739.65
[1] JIA Chuan-liang, WANG Li, CHEN Xiu-mei, SONG Xi-cheng. null [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 83-83.
[2] LU Guo-wei， WANG Lin, SUN Yan， LI Wei， HUA Hui， GE Rui-feng. Detection of different subtypes of HPV DNA in 57 cases of laryngeal carcinoma in easter of the shandong province [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 16-19.
[3] SUN Rui-jie, XU Feng-lei, LIU Da-yu, LEI Da-peng, PAN Xin-liang. Effect of CO2 laser surgery combined with interferon on recurrent juvenile laryngeal papillomatosis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 23-25.
[4] CHEN Yong, XIE Xiu-fang, LIU Fang, JIANG Yi, LI Rui-yu. Treatment of laryngeal papilloma with bone marrow mesenchymal stem cells transfected with the IFN-γ gene [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 24-27.
[5] ZHANG Shu-jia1, LI Pei-hua2, JIA Wen-bo1, XU Heng-guang1, BAO Feng-xiang1, LI Li1. 1. Expression and clinical significance of programmed cell death 5 (PDCD5) in laryngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 23-26.
[6] LI Da-wei, DONG Pin, GAO Shang. Significance of apoptotic and proliferative indices and  P-glycoprotein expression in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 8-12.
[7] WU Hongliang1, GAO Yanyong1, YU Junxiong2, TAO Zanying3, LIU Qianghe1, HE Xiaosong1, GENG Wanping1. Effect of patient-controlled intravenous analgesia for endoscopic sinus surgery on plasma IL-6 and IL-10 [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 44-47.
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 73-74.
[9] XU Hong-ming， DONG Pin， SUN Zhen-feng， WANG Guo-liang， WANG Fei. Preliminary study of animal models for laryngeal surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 15-.
[10] YI Hai-jin1， ZHANG Bao-quan2, WANG Chun-hong1, GUO Hong1, NI Fu-qiang1. Clinical analysis and treatment of recurrent laryngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 18-21.
[11] LI Zhi-zhang1, LI Qin2, GENG Yu-yan3， SHAO Yang1. Effect and significance of the TGF-β1/Smad4 signaling system in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 16-.
[12] JIANG Shao-hong, SONG Xi-cheng, ZHANG Qing-quan, ZHU Yu-hong, SUN Yan, ZHANG Hua, WANG Qiang. Therapeutic effect of endoscopic sinus surgery on cyst of the  nasal sinus with an image navigation system [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 60-62.
[13] SUN Yan, SONG Xi-cheng, ZHANG Qing-quan, ZHANG Hua, LIU Zhong-lu, WANG Qiang, JIANG Shao-hong, LIU Fei-fei. Application of image navigation in maxillary sinus surgery  for benign pathological bone lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 63-.
[14] ZENG Zhi-mei1, LIANG Yong-hui2, YANG Yi-fang2, DOU Xiao-qing2,LUO Bi-qiang2, ZHANG Li-wei2, CHEN Xian-ming2. Expression of macrophage migration inhibitory factor  in human carcinomas of the hypopharynx [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 17-19.
[15] GAO Shang, DONG Pin, LI Da-Wei, SHEN Bin. Potential mechanism of Platelet derived growth factor-BB to  promote the proliferation and invasion of Hep2 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 20-23.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd