Objective To explore the significance of perioperative monitoring system in the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods One hundred OSAHS patients were divided into group A and group B, in which the patients in group A did not receive the systematic perioperative treatment, while the patients in group B received the treatment. The perioperative monitoring system included mainly the following: physical examination before the surgery, doctors′ consultation from different departments, determination of the obstruction by imaging studies and PSG monitoring, 3-5 days positive airway pressure treatment, tracheastomy if necessary, deep anesthesia/intensified anesthetic care, ICU monitoring after the surgery, special care at the ward, and post-discharg healthy education. The incidence of the complications was retrospectively analyzed. Results In group A, one patient died. The complictions consisted of ten postoperative primary pharyngeal hemorrhage, ten secondary hemorrhage, two tracheal obstruction, and two tracheastomy. In group B, there was no complication in all the 50 patients. No severe cardiovascular complication ever occurred in either group. The incidence of complications in group B was significantly lower than that in group A (P<0.05). Conclusions The perioperative monitoring system can obviously enhance patients′ tolerance to the operation/anesthesia, strengthen the treatment, and reduce the operative risks in the patients with OSAHS.