JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2012, Vol. 26 ›› Issue (1): 80-84.

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Cytoskeleton-associated protein in the inner ear and gene mutations cause hereditary deafness

 YANG Xia, GAO Xia   

  1. Department of Otolaryngology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School， Nanjing 210008
  • Received:2011-05-25 Online:2012-02-16 Published:2012-02-16

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Abstract:

The correlated hereditary deafness-associated genes include cytoskeletal proteins, extracellular matrix proteins, channels and gap junction proteins, transcription factor genes, mitochondrial genes and other unknown function genes. Most of the cloned genes are cytoskeletal molecules.This paper makes a summary about major structural protein associated with hair cells and the pathogenesis of gene mutations lead to hereditary deafness.

Key words: Cytoskeleton; Hair cells; Hereditary deafness

CLC Number: 

  • R764
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