JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2012, Vol. 26 ›› Issue (3): 2-4.

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Determination of erythrocyte complement receptor type 1 in children with obstructive sleep apnea hypopnea syndrome

SUN Ying-zhen, FAN Xian-liang   

  1. Department of Otolaryngology, Second Hospital of Shandong University， Jinan 250033, China
  • Received:2012-03-01 Online:2012-06-16 Published:2012-06-16

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Abstract:

Objective   To investigate the changes and clinical significance of erythrocytic immune function in children with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods   30 cases of OSAHS and 30 cases of healthy controls were recruited. The level of erythrocyte complement receptor type 1(ECR1) was assayed by enzyme linked immunosorbent assay(ELISA). Results   Expression of ECR1 was obviously lower in OSAHS children (P<0.05) , and the level of erythrocyte complement receptor type 1 was negatively related to the apnea hypopnea index(AHI) but positively to the lowest oxygen saturation(LSaO2). Conclusion   The erythrocytic immune function in the children with OSAHS is reduced and related with AHI and LSaO2, which may a cast negative effect on the whole immune system.

Key words: Child； Sleep apnea, obstructive; Erythrocyte immune function; Enzyme linked immunosorbent assay; Erythrocyte complement receptor type 1

CLC Number: 

  • R766.7
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