JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2012, Vol. 26 ›› Issue (3): 28-32.

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Relationship of TGF-β1G-800A and C-509T polymorphisms to susceptibility of papillary thyroid carcinoma

WANG Xin-ru1,2,  LIU Zhi-yan3,  LI Li-zhen1, HUANG Tao2,  XIA Bin4, LI Fang-lin1,2   

  1. 1.Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Institute of Diagnosis, Medical School of Shandong University, Jinan 250012, China; 3. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China 4. Department of Aneathesia, Shandong Provincial Hospital Affiliated Shandong University, Jinan 250021, China
  • Received:2012-03-10 Online:2012-06-16 Published:2012-06-16

Abstract:

Objective   To observe single nucleotide polymorphisms of transforming growth factor-β1(TGF-β1) G-800A and C-509T, and to analyze the relationship between different types of their polymorphisms and susceptibility of papillary thyroid carcinoma (PTC) in Han adults in Jinan city. Methods   Distribution of alleles of TGF-β1 G-800A and C-509T SNP were analyzed by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). The linkage disequilibrium relationships were observed between susceptibility of the PTC and TGF-β1 G-800A and C-509T polymorphisms in a case-control study. Results   TGF β-1 C-509 T and G-800 A linkage equilibrium factors are D′= 0.75, r2=0.83, P=0.03; In a population of Han located in Jinan city: adjusted by wild type GC, number of T GF β-1 GT haploid type, in both PTC patients and control, OR was 2.206(P<0.0001), this demonstrated that GT haploid type strengthened PTC susceptibility; The TGF β-1 G/G + C/C genotype,adjusted by non-mutated TGF β-1 G/G + C/C in both PTC patients and control, OR was 2.437(P=0.010). This demonstrated that the TGF β-1 G/A+T/T genotype enhanced PTC susceptibility; TGF β-1 C-509 T T/T was related to the wild type  C/C, OR=3.826, P<0.0001, that demonstrated that the TGF β-1 C-509 T T/T haploid type strengthened PTC susceptibility. Conclusion   In the Jinan Han ethnic group, the TGF-β 1 haploid type GT and merged genotype GA+TT increased PTC susceptibility. Also, the TGF β1 C509 T T/T genotype significantly increased susceptibility to PTC. TGF-β1 in G-800A, and C-509T chain single nucleotide polymorphisms can be used as markers for individual monitoring. TGFβ1 C-509T was closely related to high risk of PTC and might be a therapeutic target in PTC.

Key words: Papillary thyroid carcinoma; Single nucleotide polymorphism; Transforming growth factor-β1

CLC Number: 

  • R736.1
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