JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (2): 1-8.doi: 10.6040/j.issn.1673-3770.0.2014.236

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Clinical investigation of sleep disorders and related factors in Alzheimer's disease

HE Ying-xue1, CONG Lin2, DU Yi-feng2   

  1. 1. Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2014-07-14 Online:2015-04-16 Published:2015-04-16

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Abstract: Objective To describe the characteristic of sleep disorders in patients with Alzheimer's disease and discuss the relationships between sleep disorder and cognitive function, psychiatric symptoms, living abilities and the caregiver burden. Methods 33 patients with Alzheimer's disease were recruited from clinics of Shandong Provincial Hospital. MMSE was used to measure the cognitive function and the degree of dementia. PSQI and ESS were used to evaluate the sleep disorders of the patients. The data were analyzed with software SPSS version 21.0. Results All items in PSQI occured in AD patients. The most common symptoms were sleep disturbance (57.6%), followed by reduction of sleep efficiency (54.5%) and daytime dysfunction (51.5%), most of which were of mild impairment. The least common item is the using of hypnotic drugs (9.1%). In PSQI, the sleep quality, difficulty falling asleep, sleep time, sleep efficiency were negatively related to MMSE score. In MMSE, orientation, immediate memory, drawing were negatively related to PSQI score. NPI and CSDD scores were both possitively related to PSQI score. Delusion, apathy, sleep/behavior at night and depression were more related to sleep disorders. Patients with sleep disorders had higher ADL and ZBI scores than patients without sleep disorder. Conclusion Various kinds of sleep disorders can occur in the process of Alzheimer's disease. The sleep disorders are closely related to the degree of dementia, cognitive function, living ability and psychiatric symptoms. Also, sleep disorders aggravate the patients' caregiver burden.

Key words: Daytime sleepiness, Epworth sleepiness scale, Sleep disorder, Pittsburgh sleep quality index, Alzheimer's disease

CLC Number: 

  • R741
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