JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (5): 1-4.doi: 10.6040/j.issn.1673-3770.0.2016.404

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Obesity and obstructive sleep apnea.

LI Yanzhong   

  1. Department of Otolaryngology &Head and Neck Surgery, Qilu Hospital of Shandong University / Key Laboratory of Otolaryngology of Health Ministry, Shandong University, Jinan 250012, Shandong, China
  • Received:2016-09-19 Online:2016-10-20 Published:2016-10-20

Abstract: The relationship between obesity and obstructive sleep apnea-hypopnea syndrome(OSAHS)has become a new hot spot in the research of sleep-disordered breathing. Whether there is a cause-and-effect or accompanying relationship between them is not yet clear. Compared with craniofacial malformations, obesity is more likely to induce obstructive sleep apnea syndrome(OSA). The frequency and severity of OSA are related to BMI and obesity. This paper discusses the relationship from four aspects: lipid metabolism disorder, fatty liver, metabolic inflammation, and oxidative stress.

Key words: Obesity, Fatty liver, Metabolic inflammation, Obstructive sleep apnea hypopnea syndrome, Disorder of lipid metabolism, Oxidative stress

CLC Number: 

  • R766.7
[1] Malhotra A, White D P. Obstructive sleep apnea[J]. Lancet, 2002, 360(9328): 237-245.
[2] Olea E, Agapito M T, Gallego-Martin T, et al. Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure[J]. J Appl Physiol, 2014, 117(7): 706-19.
[3] Toyama Y, Chin K, Chihara Y, et al. Association between sleep apnea, sleep duration, and serum lipid profile in an urban, Smale, working population in Japan[J]. Chest, 2013, 143(3): 720-728.
[4] Ge H, Cha J Y, Gopal H, et al. Differential regulation and properties of Angiopoietin-like proteins 3 and 4[J]. J Lipid Res, 2005, 46(7): 1484-1490.
[5] Shimamura M, Matsuda M, Ando Y, et al. Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma riglyceride-increasing factor[J]. Biochem Biophys Res Commun, 2004, 322(3): 1080-1085.
[6] van Rossum C T, Hoebee B, van Baak M A, et al. Genetic variation in the leptin receptor gene leptin and weight gain in young Dutch adults[J]. Obes Res, 2003, 11(3): 377-86.
[7] Zhen Y Q, Wu Y M, Sang Y H, et al. 2, 3-Oxidosqualene cyclase protects liver cells from the injury of intermittent hypoxia by regulating lipid metabolism[J]. Sleep Breath, 2015, 19(4): 1475-1481.
[8] Gharib S A, Khalyfa A, Abdelkarim A, et al. Intermittent hypoxia activates temporally coordinated transcriptional programs in visceral adipose tissue[J]. J Mol Med(Berl), 2012, 90(4): 435-445.
[9] Tanne F, Gagnadoux F, Chazouilleres O, et al. Chronic liver injury during obstructive sleep apnea[J]. Hepatology, 2005, 41(6): 1290-1296.
[10] Sookoian S, Pirola C J. Obstructive sleep apnea is associated with fatty liver and abnormal liver enzymes: a meta-analysis[J]. Obes Surg, 2013, 23(11): 1815-1825.
[11] Musso G, Cassader M, Olivetti C, et al. Association of obstructive sleep apnea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis[J]. Obes Rev, 2013, 14(5): 417-431.
[12] Ar?soy A, Sertogullar?ndan B, Ekin S, et al. Sleep Apnea and Fatty Liver Are Coupled Via Energy Metabolism[J]. Med Sci Monit, 2016, 19(22): 908-913.
[13] St-Onge M P, Shechter A. Sleep disturbances, body fat distribution, food intake and/or energy expenditure: pathophysiological aspects[J]. Horm Mol Biol Clin Investig, 2014, 17(1): 29-37.
[14] Hotamisligil G S. Inflammation and metabolic disorders[J]. Nature, 2006, 444(7121): 860-867.
[15] Li J, Savransky V, Nanayakkara A, et al. Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia[J]. J Appl Physiol(1985), 2007, 102(2): 557-563.
[16] Savransky V, Nanayakkara A, Vivero A, et al. Chronic intermittent hypoxia predisposes to liver injury[J]. Hepatology, 2007, 45(4): 1007-1013.
[17] Lu C H, Lin H C, Huang C C, et al. Increased circulating endothelial progenitor cells and anti-oxidant capacity in obstructive sleep apnea after surgical treatment[J]. Clin Chim Acta, 2015, 25(448): 1-7.
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