JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (1): 45-49.doi: 10.6040/j.issn.1673-3770.0.2017.027

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Effects of rosiglitazone on oxidative stress and cognitive function in mice exposed to intermittent hypoxia.

  

  1. 1. Department of Otolaryngology &Head and Neck Surgery;2. Sleep Center, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China
  • Received:2017-01-17 Online:2017-02-16 Published:2017-02-16

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Abstract: Objective To study the effects of PPAR gamma agonist rosiglitazone on the oxidative stress and cognitive functionon in mice exposed to intermittent hypoxia. Methods Sixty healthy male ICR mice were randomly divided into: the normoxic control group(UC group, n=12), the intermittent hypoxia group(IH group, n=12), the low dose of rosiglitazone intervention group(1 mg/kg ROS+IH group, n=12), the middle dose of rosiglitazone intervention group(3 mg/kg ROS+IH group, n=12), and the high dose of rosiglitazone intervention group(9 mg/kg ROS+IH group, n=12). IH group and groups treated with rosiglitazone were exposed to intermittent hypoxia cabin with discontinuous gas, eight hours each day. After four weeks intervention, mice were divided into two parts. The MDA and SOD assay kits were used to measure MDA and SOD concentration of mice in part one and Morris water maze test was used to detect the learning and memory function of the remaining mice. Results Compared with the UC group, the MDA concentration increased(P<0.05)and the SOD concentration decreased(P<0.05)in the IH group; compared with IH group, MDA concentration of the groups treated with rosiglitazone decreased in a dose-dependent manner(P<0.05)and SOD concentration increased. Compared with group UC, the average escape latency became longer, the times of crossing the platform and the time percentage spent in the platform quadrant reduced in the IH group; compared with the IH group, average escape latency shortened, frequency of crossing the platform and the percentage of time spent in platform quadrant increased in the 9 mg/kg ROS+IH group(P<0.05). Conclusion PPAR gamma agonist-rosiglitazone can improve the oxidative stress damage and cognitive dysfunction induced by intermittent hypoxia in mice.

Key words: Oxidative stress, Sleep apnea, obstructive, Cognitive function, Intermittent hypoxia

CLC Number: 

  • R766.7
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