J Otolaryngol Ophthalmol Shandong Univ ›› 2017, Vol. 31 ›› Issue (6): 92-96.doi: 10.6040/j.issn.1673-3770.0.2017.188

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Common susceptibility genes of primary open-angle glaucoma.

ZHAO Dongdong1,2, WANG Yi3, GAO Jianlu2.   

  1. Taishan Medical College, Taian 271000, Shandong, China;2. Department of Ophthalmology, Liaocheng Peoples Hospital, Liaocheng 252000, Shandong, China;3. Department of Opthalmology, Affiliated Hospital of Taishan Medical College, Taian 271000, Shandong, China
  • Received:2017-05-02 Online:2017-12-16 Published:2017-12-16

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Abstract: Primary open-angle glaucoma(POAG)is a neuropathy that can lead to irreversible visual field defects, and it is currently the second major disease in the world known to cause blindness. To date, significant research has demonstrated that genes and genetic variation play an important role in the glaucomatous pathogenesis; however, the mechanism is not yet entirely clear. Although more than 20 loci have been found to be linked with POAG, only three underlying genes have been identified(MYOCilin, optineurin, and WD repeat domain 36). The newly discovered caveolin 1/caveolin 2 gene and candidate gene cytochrome P450 family 1 subfamily B member 1 have also become hotspots in glaucoma genetic research. In this article, we will review the location, structure, and possible mechanisms of action of the aforementioned five pathogenic genes in relation to the pathogenesis of POAG.

Key words: Genetic variation, POAG, Pathogenic mechanism, Virulence gene

CLC Number: 

  • R775.2
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