Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 119-123.doi: 10.6040/j.issn.1673-3770.0.2018.289

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An analysis of 764 positive skin prick test results for Dermatophagoides farinae in patients with allergic rhinitis

HONG Dongdong1, LIU Yuanxian2, ZOU Lianqiang1, WENG Juanling1, DENG Wenxian1   

  1. Department of Otorhinolaryngology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, Guangdong, China
  • Online:2019-01-20 Published:2019-01-28

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Abstract: Objective This study aimed to explore factors influencing a positive skin prick test for Dermatophagoides farinae(SPT-DF)in patients with allergic rhinitis(AR)and the correlation between positive SPT-DF results and AR symptoms. Methods SPT-DF was performed for suspected AR patients using SPT diagnostic reagents, and 764 SPT-DF-positive results were analyzed statistically. Results Of 764 SPT-DF-positive patients, 18(2.36%)were positive level “+”(level one); 23(3.10%)were positive level “++”(level two); 196(25.65%)were positive level “+++”(level three); and 527(68.98%)were positive level “++++”(level four). The differences in positive levels between SPT-DF-positive patients in six age groups(0-4 years, 5-14 years, 15-29 years, 30-44 years, 45-59 years, and 60-69 years)were statistically significant(χ2 = 20.138, P=0.001), and SPT-DF-positive levels decreased with advancing age-group ranges. There were no significant differences in positive levels between male and female SPT-DF-positive patients(Z=-1.503, P=0.133). In the age groups 15-29 years and 30-44 years, the positive level differences between male and female SPT-DF-positive patients were statistically significant(15-29 years, Z=-2.337, P=0.013; 30-44 years, Z=-3.129, P=0.001), with the positive levels of female patients being higher than those of male patients. Of 764 patients, 332(43.46%)had AR only. There were 432(56.54%)patients with other allergic diseases(allergic conjunctivitis, asthma, and allergic dermatitis), 367(48.03%)patients with two kinds of allergic diseases, 35(4.58%)patients with three kinds, and 30(3.93%)patients with four kinds. The number of patients with allergic diseases were as follows: allergic conjunctivitis, n=331; allergic dermatitis, n=56; and asthma, n=42. Among 764 SPT-DF-positive patients, differences in the positive levels between SPT-DF-positive patients with different numbers of allergic disease types were statistically significant(χ2=26.065, P=0.000), and the higher the number of allergic disease types, the higher the SPT-positive level. There were no significant differences in scores with respect to sneezing(F=0.207, P=0.891), runny nose(F=0.297, P=0.827), nasal congestion(F=0.174, P=0.913), nasal itching(F=0.256, P=0.857), itchy eyes(F=0.044, P=0.987), tearing(F=0.154, P=0.926), and the total symptom score(F=0.211, P=0.884)between different SPT-DF-positive levels. There was also no correlation found between SPT-DF-positive levels and scores with respect to sneezing(rs=-0.036, P=0.387), runny nose(rs=-0.034, P=0.392), nasal congestion(rs=-0.026, P=0.433), nasal itching(rs=0.056, P=0.141), itchy eyes(rs=-0.039, P=0.379), tearing(rs=-0.041, P=0.374), and total symptom score(rs=0.032, P=0.397). Conclusion The SPT-DF-positive levels are affected by age and the number of allergic disease types in patients with AR, but are not affected by sex differences. The SPT-DF-positive levels have no correlation with AR symptom scores.

Key words: Allergic rhinitis, Dermatophagoides farinae, Skin prick test

CLC Number: 

  • R765.21
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