Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 99-102.doi: 10.6040/j.issn.1673-3770.0.2018.567

Previous Articles     Next Articles

Analysis of pulmonary function and its influencing factors in chronic rhinosinusitis without lower airway disease

WANG Yakun1,2, ZHANG Yu3, SONG Xicheng3   

  1. Department of Otorhinolaryngology, Yantai Yuhuangding Laishan Hospital, Yantai 264003, Shandong, China;
    3. Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Online:2019-01-20 Published:2019-01-28

PDF (PC)

295

Abstract: Objective To explore pulmonary function and its related influences in chronic rhinosinusitis patients with nasal polyps(CRSwNP)without lower airway disease. Methods One hundred and sixty-one patients with chronic rhinosinusitis with nasal polyps(CRSwNP), 26 patients with chronic rhinosinusitis without nasal polyps(CRSsNP), and 34 healthy people serving as a control group were enrolled in this study. We compared pulmonary function among these three groups and analyzed the association between pulmonary function and clinical parameters in patients with CRSwNP. These clinical parameters included serum eosinophil count, serum-specific allergen IgE(sIgE), Lund-Mackay scores, exhaled nitric oxide levels, and VAS scores. Results Percentages of predicted forced expiratory volume in 1 second(FEV1%pre)in the CRSwNP group were significantly lower than those in the control group(P<0.05), and sIgE was negatively correlated with vital capacity(VC), FEV1%pre, and FEV1/FVC(P<0.05). Conclusion The results suggest a potential obstructive pulmonary function change in patients with chronic rhinosinusitis. Serum-specific allergen IgE may be associated with changes in lung function in chronic rhinosinusitis.

Key words: Chronic rhinosinusitis, Nasal polyps, Pulmonary function, Lower airways, Factors

CLC Number: 

  • R765.4
[1] Fokkens WJ, Lund VJ, Mullol J, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists[J]. Rhinology, 2012, 50(1):1-12. doi:10.4193/Rhino50E2.
[2] 罗向前. 中国慢性鼻-鼻窦炎患者多中心临床特征调查[D]. 广州: 中山大学, 2014.
[3] Batra PS, Tong LY, Citardi MJ. Analysis of comorbidities and objective parameters in refractory chronic rhinosinusitis[J]. Laryngoscope, 2013, 123(Suppl 7):S1-S11. doi:10.1002/lary.24418.
[4] Katotomichelakis M, Simopoulos E, Zhang N, et al. Olfactory dysfunction and asthma as risk factors for poor quality of life in upper airway diseases[J]. Am J Rhinol Allergy, 2013, 27(4):293-298. doi:10.2500/ajra.2013.27.3903.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 慢性鼻-鼻窦炎诊断和治疗指南(2012年, 昆明)[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(2):92-94. doi: 10.3969/j.issn.1008-1070.2013.11.049. Guidelines for diagnosis and treatment of chronic rhinitis and nasal sinusitis(2012, Kunming)[J]. Chin J Otorhinolaryngol Head Neck Surg, 2013, 48(2):92-94. doi: 10.3969/j.issn.1008-1070.2013.11.049.
[6] Bousquet J, Van Cauwenberge P, Khaltaev N, et al. Allergic rhinitis and its impact on asthma[J]. J Allergy Clin Immunol, 2001, 108(Suppl5):S147-S334.
[7] Annesi-Maesano I. Epidemiological evidence of the occurrence of rhinitis and sinusitis in asthmatics[J]. Allergy, 1999, 54(Suppl 57):7-13.
[8] Bachert C, Vignola AM, Gevaert P, et al. Allergic rhinitis, rhinosinusitis, and asthma: one airway disease[J]. Immunol Allergy Clin North Am, 2004, 24(1):19-43. doi:10.1016/S0889-8561(03)00104-8.
[9] Jani AL, Hamilos DL. Current thinking on the relationship between rhinosinusitis and asthma[J]. J Asthma, 2005, 42(1):1-7.
[10] 李华斌,赖玉婷.慢性鼻-鼻窦炎的发病机制及诊疗进展[J].山东大学耳鼻喉眼学报,2018,32(3):4-9. doi: 10.6040/j.issn.1673-3770.1.2018.004. LI Huabin, LAI Yuting. Pathogenesis,diagnosis,and treatment of chronic rhinosinusitis [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(3):4-9. doi: 10.6040/j.issn.1673-3770.1.2018.004.
[11] Lemière C, Ernst P, Olivenstein R, et al. Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes[J]. J Allergy Clin Immunol, 2006, 118(5):1033-1039. doi:10.1016/j.jaci.2006.08.003.
[12] 刘锦铭. 限制性通气功能障碍肺功能指标特点[J]. 中国实用内科杂志, 2012, 32(8):578-580. LIU Jinming. Lung function characteristics of restrictive ventilatory dysfunction[J]. Chin J Prac Intern Med, 2012, 32(8):578-580.
[13] Zhang LH, Zhang L, Zhang CH, et al. The lung function impairment in non-atopic patients with chronic rhinosinusitis and its correlation analysis[J]. Clin Exp Otorhinolaryngol, 2016, 9(4):339-345. doi:10.21053/ceo.2015.01641.
[14] Kariya S, Okano M, Oto T, et al. Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis[J]. J Laryngol Otol, 2014, 128(3):255-262. doi:10.1017/S0022215114000450.
[15] Lewis SA, Pavord ID, Stringer JR, et al. The relation between peripheral blood leukocyte counts and respiratory symptoms, atopy, lung function, and airway responsiveness in adults[J]. Chest, 2001, 119(1):105-114. doi: 10.1378/chest.119.1.105.
[16] Rohde G, Gevaert P, Holtappels G, et al. Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD[J]. Respir Med, 2004, 98(9):858-864. doi: 10.1016/j.rmed.2004.02.012.
[1] CUI Le, GUAN Kai, LI Lisha, LI Junda, WANG Zixi, XU Yingyang, WANG Lianglu, YIN Jia. Analysis of prevalence and related risk factors of bee venom in bee research population [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 63-66.
[2] Yu ZHANG,Xicheng SONG. Advances in interaction mechanisms and treatment strategy between chronic rhinosinusitis with nasal polyp and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 49-52.
[3] DU Jingwei, FENG Jun, MA Peng, LI Zhiyong, LI Hongguang. Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 124-127.
[4] Hongmeng YU,Zhuofu LIU,Qi DAI. Endoscopic sinus surgery for chronic sinusitis with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 38-41.
[5] CAO Cheng, XU Yu. Clinical compliance and related factors to sublingual immunotherapy in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 114-118.
[6] WANG Jianwei, ZHANG Yu, SONG Xicheng. Analysis of pulmonary function of patients who developed chronic rhinosinusitis with nasal polyps and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 103-108.
[7] HOU Xiaobing, REN Tongli, ZHANG Yibo. Characteristics of tinnitus and the related influencing factors in patients with Menieres disease [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 37-40.
[8] LIAO Libing, LIU Qiming, ZONG Ling, ZHAI Jinming, ZHANG Jianguo. Characteristics of 42 patients with tinnitus and hyperacusis [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 31-36.
[9] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[10] SONG Xiaoyu, ZHANG Yu, LI Chenglin, SONG Xicheng. Enhanced recovery after surgery for the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 9-12.
[11] HUANG Yuan, BA Luo, LI Bo, YU Wenxing, YANG Fangli, DU Jintao. Transcription factor NKX2-1 regulates eosinophilic inflammation in chronic rhinosinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 17-23.
[12] CHEN Wangxing, ZHAO Xue, LIU Yan, LIU Yue, JIN Chunshun. Psychological status of patients with deviated nasal septum or chronic sinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 24-27.
[13] Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps. Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 28-31.
[14] LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 4-9.
[15] YU Qianqian, GUAN Ge, ZHANG Niankai, LI Na, WEN Junfeng, LIU Tingting, LIAN Yuanyuan. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 76-81.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] YANG Changliang,HUANG Zhiwu,YAO Hangqi,ZHU Yong,SNU Yi . Study on auditory brainstem response[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 9 -13 .
[2] WAN Li-jia,LU Hai-tao,JIANG Yi-dao,LIU Hui,LI Qin,SHE La-zhi . Effect of H-uvulopalatopharyngoplasty on obstructive sleep apnea
hypopnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 204 -205 .
[3] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[5] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[6] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 227 -227 .
[7] LIN Feng,LIANG Yong,LU Yong-tian,WAN Li-xia . Classification and surgical treatment for nasal inverted papilloma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 231 -233 .
[8] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[9] LOU Zheng-cai,LOU Fang-yi,JIN Zhong-hai . Etiological analysis of paraesthesia pharynx in 405 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 271 -275 .
[10] YU Zhi-liang,WANG Wei-wei,WANG Ming-hua . Excision of huge epiglottis cysts under MedtrnicXPS3000 in 23 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 278 -279 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd