Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 145-148.doi: 10.6040/j.issn.1673-3770.0.2018.301

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Correlation between endolymphatic hydrops and inner ear epithelial sodium channels and aquaporins

HUANG Qiao,YIN Shihua   

  1. Department of Otolaryngology & Head and Neck Surgery, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi, China
  • Online:2019-07-20 Published:2019-07-22

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Abstract: Endolymphatic hydrops is the main pathological disorder in Meniere's disease, although the precise mechanism is not fully understood. Studies have confirmed that endolymphatic hydrops is closely related to the inner ear ion and water transport channels. This article reviews the studies on the correlation between endolymphatic hydrops and inner ear epithelial sodium channels(ENaC)and aquaporins(AQPs)and discusses the mechanism underlying endolymphatic hydrops to provide favorable references for future studies on the pathogenesis and treatment of Meniere's disease.

Key words: Epithelial sodium channel, Aquaporins, Endolymphatic metabolism, Endolymphatic hydrops

CLC Number: 

  • R764.33
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