Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 145-148.doi: 10.6040/j.issn.1673-3770.0.2018.301

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Correlation between endolymphatic hydrops and inner ear epithelial sodium channels and aquaporins

HUANG Qiao,YIN Shihua   

  1. Department of Otolaryngology & Head and Neck Surgery, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi, China
  • Online:2019-07-20 Published:2019-07-22

Abstract: Endolymphatic hydrops is the main pathological disorder in Meniere's disease, although the precise mechanism is not fully understood. Studies have confirmed that endolymphatic hydrops is closely related to the inner ear ion and water transport channels. This article reviews the studies on the correlation between endolymphatic hydrops and inner ear epithelial sodium channels(ENaC)and aquaporins(AQPs)and discusses the mechanism underlying endolymphatic hydrops to provide favorable references for future studies on the pathogenesis and treatment of Meniere's disease.

Key words: Epithelial sodium channel, Aquaporins, Endolymphatic metabolism, Endolymphatic hydrops

CLC Number: 

  • R764.33
[1] Andrews JC, Honrubia V. Premenstrual exacerbation of Meniere's disease revisited[J]. Otolaryngol Clin North Am, 2010, 43(5): 1029-1040. doi:10.1016/j.otc.2010.05.012.
[2] Kim SH, Marcus DC. Regulation of sodium transport in the inner ear[J]. Hear Res, 2011, 280(1/2): 21-29. doi:10.1016/j.heares.2011.05.003.
[3] Kim BG, Kim JY, Kim HN, et al. Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops[J]. PLoS One, 2014, 9(4): e95730. doi:10.1371/journal.pone.0095730.
[4] Couloigner V, Fay M, Djelidi S, et al. Location and function of the epithelial Na channel in the cochlea[J]. Am J Physiol Renal Physiol, 2001, 280(2): F214-F222. doi:10.1152/ajprenal.2001.280.2.F214.
[5] Gründer S, Müller A, Ruppersberg JP. Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat[J]. Eur J Neurosci, 2001, 13(4): 641-648.
[6] 温雅, 钟时勋, WEN Ya, 等. 去氨加压素对耳蜗功能及上皮钠通道表达的调节作用[J]. 中华耳科学杂志, 2014, 12(3): 498-502. doi:10.3969/j.issn.1672-2922.2014.03.037. WEN Ya, ZHONG Shixun, WEN Ya, et al. Regulation of epithelial sodium channels and cochlear function by desmopressin[J]. Chinese Journal of Otology, 2014, 12(3): 498-502. doi:10.3969/j.issn.1672-2922.2014.03.037.
[7] Kakigi A, Okada T, Takeda T, et al. Presence and regulation of epithelial sodium channels in the marginal cells of stria vascularis[J]. Acta Otolaryngol, 2008, 128(3): 233-238. doi:10.1080/00016480701413821.
[8] Kim SH, Kim KX, Raveendran NN, et al. Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium[J]. Am J Physiol, Cell Physiol, 2009, 296(3): C544-C557. doi:10.1152/ajpcell.00338.2008.
[9] Snyder PM, Olson DR, Kabra R, et al. cAMP and serum and glucocorticoid-inducible kinase(SGK)regulate the epithelial Na(+)channel through convergent phosphorylation of Nedd4-2[J]. J Biol Chem, 2004, 279(44): 45753-45758. doi:10.1074/jbc.M407858200.
[10] Zhong SX, Hu GH, Liu ZH. Expression of ENaC, SGK1 and Nedd4 isoforms in the cochlea of guinea pig[J]. Folia Histochem Cytobiol, 2014, 52(2): 144-148. doi:10.5603/FHC.2014.0010.
[11] 李琦, 黄德亮. 醛固酮对豚鼠耳蜗离子通道蛋白的早期作用[J]. 中华耳科学杂志, 2007, 5(2): 221-224. LI Qi, HUANG Deliang. The pristine effect of aldosterone guinea pig's on ionophorous proteins in cochlea[J]. Chinese Journal of Otology, 2007, 5(2): 221-224.
[12] Mori N, Miyashita T, Inamoto R, et al. Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere's disease[J]. Eur Arch Otorhinolaryngol, 2017, 274(4): 1813-1820. doi:10.1007/s00405-016-4362-1.
[13] Qin L, Zhang BY, Wang QY, et al. Effect of aldosterone on cochlear Af9 expression and hearing in guinea pig[J]. Acta Otolaryngol, 2017, 137(9): 903-909. doi:10.1080/00016489.2017.1309681.
[14] Eckhard A, Gleiser C, Arnold H, et al. Water channel proteins in the inner ear and their link to hearing impairment and deafness[J]. Mol Aspects Med, 2012, 33(5/6): 612-637. doi:10.1016/j.mam.2012.06.004.
[15] Miyoshi T, Yamaguchi T, Ogita K, et al. Quantitative analysis of aquaporin expression levels during the development and maturation of the inner ear[J]. J Assoc Res Otolaryngol, 2017, 18(2): 247-261. doi:10.1007/s10162-016-0607-3.
[16] 林琳, 黄德亮. 水通道蛋白最新进展与内耳疾病[J]. 中华耳科学杂志, 2004, 2(2): 148-153. doi:10.3969/j.issn.1672-2922.2004.02.019.
[17] 梁书锋, 郑鸣. 水通道蛋白在耳部的研究进展及其临床意义[J]. 解剖与临床, 2006, 11(1): 66-67. doi:10.3969/j.issn.1671-7163.2006.01.027.
[18] Ishiyama G, Lopez IA, Beltran-Parrazal L, et al. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma[J]. Cell Tissue Res, 2010, 340(3): 407-419. doi:10.1007/s00441-010-0975-7.
[19] Gu FM, Han HL, Zhang LS. Effects of vasopressin on gene expression in rat inner ear[J]. Hear Res, 2006, 222(1/2): 70-78. doi:10.1016/j.heares.2006.08.016.
[20] Maekawa C, Kitahara T, Kizawa K, et al. Expression and translocation of aquaporin-2 in the endolymphatic sac in patients with Meniere's disease[J]. J Neuroendocrinol, 2010, 22(11): 1157-1164. doi:10.1111/j.1365-2826.2010.02060.x.
[21] Nevoux J, Viengchareun S, Lema I, et al. Glucocorticoids stimulate endolymphatic water reabsorption in inner ear through aquaporin 3 regulation[J]. Pflugers Arch, 2015, 467(9): 1931-1943. doi:10.1007/s00424-014-1629-5.
[22] Hirt B, Penkova ZH, Eckhard A, et al. The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier[J]. Neuroscience, 2010, 168(4): 957-970. doi:10.1016/j.neuroscience.2009.09.002.
[23] Perin P, Tritto S, Botta L, et al. Aquaporin-6 expression in the cochlear sensory epithelium is downregulated by salicylates[J]. J Biomed Biotechnol, 2010, 2010: 264704. doi:10.1155/2010/264704.
[24] Takeda T, Taguchi D. Aquaporins as potential drug targets for Meniere's disease and its related diseases[J]. Handb Exp Pharmacol, 2009(190): 171-184. doi:10.1007/978-3-540-79885-9_8.
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