Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 82-86.doi: 10.6040/j.issn.1673-3770.0.2018.234

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Risk factors and prognosis of esophageal cancer with hypopharyngeal carcinoma

HUANG He, OUYANG Hui   

  1. Department of Otorhinolaryngology Head and Neck Surgery, the First People′s Hospital of Neijiang City, Neijiang 610041, Sichuang, China
  • Online:2019-07-20 Published:2019-07-22

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Abstract: Objective To investigate the risk factors and prognosis of hypopharyngeal carcinoma patients with esophageal cancer. Methods This study included 200 patients with esophageal cancer in our hospital from January 2011 to March 2014. General data, tumor information, and follow-up of patients were retrospectively analyzed. First, the risk factors of esophageal cancer with hypopharyngeal carcinoma were analyzed by univariate analysis with comparisons between groups using the chi square test(2). Logistic regression analysis was then performed for factors with statistical differences. The Kaplan-Meier method was used to analyze the survival rate. Results Single-factor analysis revealed that age(<55 years), male gender, severe smoking history, severe alcohol consumption history, and >3 tumor invasion sites were high risk factors for comorbidity of esophageal cancer in hypopharyngeal cancer patients(P<0.05). The results of the multifactor analysis showed that age(<55 years), severe smoking history, severe alcohol consumption history, and >3 tumor invasion sites were independent risk factors for comorbidity of hypopharyngeal carcinoma(P<0.05). The median survival time of the 200 hypopharyngeal cancer patients was 37.5 months, and the 5-year survival rate was 36.7%. The median survival time of 56 patients with concurrent hypopharyngeal carcinoma and concurrent esophageal cancer was 24.8 months, which was significantly lower than that in patients with hypopharyngeal carcinoma without concurrent esophageal cancer(P<0.05). The median survival time in patients with early-stage esophageal carcinoma(0+Ⅰ stage)was 29.2 months, which was significantly higher than that in patients with advanced esophageal carcinoma(Ⅱ+Ⅲ stage), and the difference was statistically significant(P<0.05). Conclusion The survival time in hypopharyngeal cancer patients with concurrent esophageal cancer is relatively low. Age(<55 years), severe smoking history, severe alcohol consumption history, and >3 tumor invasion sites are independent risk factors for comorbidity of hypopharyngeal cancer, and early interventions should be implemented in clinical practice.

Key words: Hypopharyngeal carcinoma, Esophageal cancer, Prognosis, Risk factors

CLC Number: 

  • R739.6
[1] Rodrigo JP, Grilli G, Shah JP, et al. Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review[J]. Eur J Surg Oncol, 2018, 44(4): 395-403. doi:10.1016/j.ejso.2018.01.003.
[2] Osumi H, Yoshio T, Chin K, et al. Chemotherapy is effective for stage I gastric cancer in patients with synchronous esophageal cancer[J]. Gastric Cancer, 2016, 19(2): 625-630. doi:10.1007/s10120-015-0517-9.
[3] Lee KD, Lu CH, Chen PT, et al. The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period[J]. BMC Cancer, 2009, 9: 373. doi:10.1186/1471-2407-9-373.
[4] Muto M, Nakane M, Katada C, et al. Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites[J]. Cancer, 2004, 101(6): 1375-1381. doi:10.1002/cncr.20482.
[5] Zhang QL, Zhao LG, Li HL, et al.The joint effects of major lifestyle factors on colorectal cancer risk among Chinese men: A prospective cohort study[J]. Int J Cancer,2018,142(6):1093-1101. doi: 10.1002/ijc.31126.
[6] 黄根牙,马兴刚,王昌成. 重度饮酒与HBV相关肝癌危险性的关系[J]. 中华肿瘤防治杂志, 2005, 12(6): 405-408. doi:10.3969/j.issn.1673-5269.2005.06.002. HUANG Genya,MA Xinggang,WANG Changcheng. Heavy alcohol consumption can enhance risk of hepatocellular carcinoma associated with hepatitis B virus infection[J]. Chinese Journal of Cancer Prevention and Treatment, 2005, 12(6): 405-408. doi:10.3969/j.issn.1673-5269.2005.06.002.
[7] 徐伟,吕正华,杨哲,等. 149例下咽癌手术及术后放射治疗的预后分析[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(7): 533-538. doi:10.3760/cma.j.issn.1673-0860.2014.07.002. XU Wei, LÜ Zhenghua, YANG Zhe, et al. Prognostic factors affecting results of comprehensive treatment of hypopharyngeal carcinoma[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery[J] , 2014, 49(7): 533-538. doi:10.3760/cma.j.issn.1673-0860.2014.07.002.
[8] Chen XM, Wang JF, Wang R, et al. Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance[J]. Eur Arch Otorhinolaryngol, 2016, 273(2): 431-438. doi:10.1007/s00405-015-3779-2.
[9] 白文文,宋玉芝,刘明,等. SIB-IMRT技术在颈及胸上段食管癌中的临床应用[J]. 中华肿瘤防治杂志, 2016, 23(4): 248-252. doi:10.16073/j.cnki.cjcpt.2016.04.010. BAI Wenwen, SONG Yuzhi, LIU Ming, et al. Clinical application of simultaneous integrated boost intensity-modulated radiation therapy in cervical and upper esophageal carcinoma[J].Chinese Journal of Cancer Prevention and Treatment, 2016, 23(4): 248-252. doi:10.16073/j.cnki.cjcpt.2016.04.010.
[10] 郑浩,汪灏,唐汉,等. 新辅助同步放化疗与新辅助化疗治疗局部进展期食管鳞癌的疗效分析[J]. 中华消化外科杂志, 2017, 16(5): 464-468. doi:10.3760/cma.j.issn.1673-9752.2017.05.006. ZHENG Hao, WANG Hao, TANG Han, et al. Effect analysis of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in the treatment of locally advanced esophageal squamous cell carcinoma[J]. Chinese Journal of Digestive Surgery, 2017, 16(5): 464-468. doi:10.3760/cma.j.issn.1673-9752.2017.05.006.
[11] Li B, Xu WW, Han L, et al. MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF[J]. Oncogene, 2017, 36(28): 3986-4000. doi:10.1038/onc.2017.29.
[12] Deng XF, Liu QX, Hou B, et al. Esophageal cancer with a synchronous multiple carcinoid of the duodenal bulb[J]. Indian J Surg, 2015, 77(6): 543-544. doi:10.1007/s12262-015-1338-0.
[13] Lo OS, Law S, Wei WI, et al. Esophageal cancers with synchronous or antecedent head and neck cancers: a more formidable challenge?[J]. Ann Surg Oncol, 2008, 15(6): 1750-1756. doi:10.1245/s10434-008-9860-y.
[14] Lee DH, Roh JL, Baek S, et al. Second cancer incidence, risk factor, and specific mortality in head and neck squamous cell carcinoma[J]. Otolaryngol Head Neck Surg, 2013, 149(4): 579-586. doi:10.1177/0194599813496373.
[15] 李思涵,陈智琴,李光. 30例头颈部鳞癌合并同时性食管癌患者疗后临床分析[J]. 中华放射肿瘤学杂志, 2017, 26(7): 728-731. doi:10.3760/cma.j.issn.1004-4221.2017.07.002. LI Sihan,CHEN Zhiqin,LI Guang,et al. A clinical analysis of 30 patients with synchronous head and neck and esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(7): 728-731. doi:10.3760/cma.j.issn.1004-4221.2017.07.002.
[16] Haguenoer JM, Cordier S, Morel C, et al. Occupational risk factors for upper respiratory tract and upper digestive tract cancers[J]. Br J Ind Med, 1990, 47(6): 380-383. doi:10.1136/oem.47.6.380.
[17] Lim H, Kim DH, Jung HY, et al. Clinical significance of early detection of esophageal cancer in patients with head and neck cancer[J]. Gut Liver, 2015, 9(2): 159-165. doi:10.5009/gnl13401.
[18] Katsoulakis E, Riaz N, Hu M, et al. Hypopharyngeal squamous cell carcinoma: Three-dimensional or Intensity-modulated radiotherapy? A single institutions experience[J]. The Laryngoscope, 2016, 126(3): 620-626. doi:10.1002/lary.25509.
[19] Visser E, Franken IA, Brosens LA, et al. Prognostic gene expression profiling in esophageal cancer: a systematic review[J]. Oncotarget, 2017, 8(3): 5566-5577. doi:10.18632/oncotarget.13328.
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