Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (6): 27-30.doi: 10.6040/j.issn.1673-3770.0.2019.588

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Nasal chondromesenchymal hamartoma in infants: A report of two cases and literature review

CHEN Kun,LI Lei, MENG Guozhen, YANG Jun, HOU Dongming   

  1. Department of Otolaryngology & Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
  • Published:2021-01-11

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Abstract: Objective This study aimed to investigate the clinical and pathological features, diagnosis, treatment, and prognosis of nasal chondromesenchymal hamartoma(NCMH)in infants. Method We performed a retrospective analysis of the clinical and pathological data of two infants with NCMH admitted to the Xinhua Hospital affiliated with the Shanghai Jiao Tong University School of Medicine between May 2016 and March 2019. The diagnosis, treatment, and prognosis of the patients were also investigated. Results The NCMHs originated from the nasal cavity or skull base and were completely resected by nasal endoscopy. There was no recurrence in long-term follow-up. Histologically, the mesenchymal cells and collagen fibers showed benign hyperplasia around cartilage structures. Conclusion The clinical manifestations of infant NCMHs are diverse and non-specific; thus, early diagnosis is difficult. Nasal endoscopic surgery is the main treatment method for NCMH and has good clinical effects.

Key words: nasal chondromesenchymal hamartoma, nasal mass, pediatric benign tumors, endoscopic excision, skull base benign tumor

CLC Number: 

  • R765
[1] McDermott MB, Ponder TB, Dehner LP. Nasal chondromesenchymal hamartoma: an upper respiratory tract analogue of the chest wall mesenchymal hamartoma[J]. Am J Surg Pathol, 1998, 22(4): 425-433. doi:10.1097/00000478-199804000-00006.
[2] 陈晓彩, 汪照炎, 曹荣萍, 等. 婴幼儿鼻腔错构瘤的诊断及鼻内镜手术治疗[J]. 中国耳鼻咽喉颅底外科杂志, 2017, 23(1): 33-38. doi: CNKI:SUN:ZEBY.0.2017-01-012. CHEN Xiaocai, WANG Zhaoyan, CAO Rongping, et al. Diagnosis and endoscopic treatment of nasal hamartoma in infants[J]. Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2017, 23(1): 33-38. doi: CNKI:SUN:ZEBY.0.2017-01-012.
[3] Golbin DA, Ektova AP, Demin MO, et al. Nasal chondromesenchymal hamartoma with skull base and orbital involvement: case presentation[J]. Cureus, 2018, 10(6): e2892. doi:10.7759/cureus.2892.
[4] Mirchia K, Naous R. Nasal chondromesenchymal hamartoma: rare case report in an elderly patient and brief review of literature[J]. Case Rep Pathol, 2018, 2018: 5971786. doi:10.1155/2018/5971786.
[5] Lee CH, Park YH, Kim JY, et al. Nasal chondromesenchymal hamartoma causing sleep-disordered breathing in an infant[J]. Int J Clin Exp Pathol, 2015, 8(8): 9643-9646.
[6] 于倩倩, 关鸽, 张念凯, 等. 鼻腔嗅裂区呼吸道上皮腺瘤样错构瘤的CT影像表现[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 76-81. doi: 10.6040/j.issn.1673-3770.0.2017.355. YU Qianqian, GUAN Ge, ZHANG Niankai, et al. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 76-81. doi: 10.6040/j.issn.1673-3770.0.2017.355.
[7] Wang TT, Li WH, Wu XR, et al. Nasal chondromesenchymal hamartoma in young children: CT and MRI findings and review of the literature[J]. World J Surg Oncol, 2014, 12: 257. doi:10.1186/1477-7819-12-257.
[8] Kitayama T, Akaki S, Hisazumi K, et al. An adult case of nasal chondromesenchymal hamartoma: imaging characteristics including diffusion-weighted images[J]. Acta Med Okayama, 2019, 73(6): 529-532. doi:10.18926/AMO/57718.
[9] Johnson C, Nagaraj U, Esguerra J, et al. Nasal chondromesenchymal hamartoma: radiographic and histopathologic analysis of a rare pediatric tumor[J]. Pediatr Radiol, 2007, 37(1): 101-104. doi:10.1007/s00247-006-0352-6.
[10] Nakaya M, Yoshihara S, Yoshitomi A, et al. Endoscopic endonasal excision of nasal chondromesenchymal hamartoma with intracranial extension[J]. Eur Ann Otorhinolaryngol Head Neck Dis, 2017, 134(6): 423-425. doi:10.1016/j.anorl.2016.05.014.
[1] HOU Dong-ming, CAO Rong-ping, MENG Guo-zhen, CHENG Lan. Diagnosis and endoscopic treatment of congenital nasal mass of infants [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(3): 36-38.
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